Support of science-based decisions concerning the evaluation of the toxicology of mixtures: A new beginning

Regulatory Toxicology and Pharmacology

Volumn 36, Issue 1, 2002, Pages 34-39

  Teuschler, Linda ^a   Klaunig, James ^b   Carney, Ed ^c   Chambers, Janice ^k   Conolly, Rory ^d   Gennings, Chris ^e   Giesy, John ^f   Hertzberg, Richard ^a   Klaassen, Curtis ^g   Kodell, Ralph ^h   Paustenbach, Dennis ⁱ   Yang, Raymond ^j   Bucher, J ^k   Bus, J ^k   Farland, W ^k   Foran, J ^k   Goodman, J ^k   Lamb, S ^k   Mason, A ^k   Parrish, R ^k   Thompson, C ^k   more..

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DOW CHEMICAL COMPANY   (United States)

^d CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^f MICHIGAN STATE UNIVERSITY   (United States)

^g UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^h National Center for Toxicology Research   (United States)

ⁱ EXPONENT INC   (United States)

^j Veterinary Dentistry and Oral Surgery   (United States)

^k Box 980032 ^*

more..

Author keywords

[No Author keywords available]

Indexed keywords

DECISION MAKING; DOSE RESPONSE; EXPERIMENTATION; EXPOSURE; METHODOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; STATISTICAL ANALYSIS; TECHNOLOGY; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS;

EID: 0036978951     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.2002.1570     Document Type: Review

References (23)

1. ATSDR (Agency for Toxic Substances and Disease Registry) (2000a). Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures.
2. ATSDR (Agency for Toxic Substances and Disease Registry) (2000b). Interaction Profile for: Chlorinated Dibenzo-p-Dioxins, Hexachlorobenzene, p,p′-DDE, and Methylmercury.
3. ATSDR (Agency for Toxic Substances and Disease Registry) (2000c). Guidance for the Preparation of an Interaction Profile.
4. Berenbaum, M. C. (1989). What is synergy? [published erratum appears in Pharmacol. Rev., 1990, 41, 422]. Pharmacol. Rev. 41, 93-141.
5. Borgert, C. J., Price, B., Wells, C., and Simon, G. S. (2001). Evaluating interaction studies for mixture risk assessment. Hum. Ecol. Risk Assess. 7, 259-306.
6. Calabrese, E. J. (1991). Multiple Chemical Interactions. Lewis, Chelsea.
7. Cassee, F. R., Groten, J. P., van Bladeren, P. J., and Feron, V. J. (1998). Toxicological evaluation and risk assessment of chemical mixtures. Crit. Rev. Toxicol. 28, 73-101.
8. Chapin, R. E., Phelps, J. L., Schwetz, B. A., and Yang, R. S. H. (1989). Toxicology studies of a chemical mixture of 25 groundwater contaminants. (III) Male reproduction study in B6C3F1 mice. Fundam. Appl. Toxicol. 13, 388-398.
9. Conolly, R. B., Beck, B. D., and Goodman, J. I. (1999). Stimulating research to improve the scientific basis of risk assessment. Toxicol. Sci. 49, 1-4.
10. Groten, J. P., Butler, W., Feron, V. J., Kozianowski, G., Renwick, A. G., and Walker, R. (2000). An analysis of the possibility for health implications of joint actions and interactions between food additives. Regul. Toxicol. Pharmacol. 32, 77-91.
11. Groten, J. P., Schoen, E. D., van Balderen, P. J., Kuper, C. F., van Zorge, J. A., and Feron, V. J. (1997). Subacute toxicity of a mixture of nine chemicals in rats: Detecting interactive effects with a fractionated two-level factorial design. Fundam. Appl. Toxicol. 36, 15-29.
12. Heindel, J. J., Chapin, R. E., Gulati, D. K., George, J. D., Price, C. J., Marr, M. C., Myers, C. B., Barnes, L. H., Fail, P. A., Grizzle, T. B., Schwetz, B. A., and Yang, R. S. H. (1994). Assessment of the reproductive and developmental toxicity of pesticide/fertilizer mixtures based on confirmed pesticide contamination in California and Iowa groundwater. Fundam. Appl. Toxicol. 22, 605-621.
13. Hertzberg, R. C., Rice, G., and Teuschler, L. K. (1999). Methods for health risk assessment of combustion mixtures. In Hazardous Waste Incineration: Evaluating the Human Health and Environmental Risks (S. Roberts, C. Taf, and J. Bean, Eds.), pp. 105-148. CRC Press LLC, Boca Raton; FL.
14. Jonker, D., Woutersen, R. A., van Bladeren, P. J., Til, H. P., and Feron, V. J. (1990). 4-Week oral toxicity study of a combination of eight chemicals in rats: Comparison with the toxicity of the individual compounds. Food Chem. Toxicol. 28, 623-631.
15. Jonker, D., Woutersen, R. A., van Bladeren, P. J., Til, H. P., and Feron, V. J. (1993). Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: Comparison with the toxicity of the individual compounds. Food Chem. Toxicol. 31, 125-136.
16. Jonker, D., Woutersen, R. A., and Feron, V. J. (1996). Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action. Food Chem. Toxicol. 34(11-12), 1075-82.
17. Kendall, J. J., Brouwer, A., and Giesy, J. P. (1998). A risk-based field and laboratory approach to assess endocrine disruption in wildlife. In Principles and Processes for Evaluating Endocrine Disruptors in Wildlife (R. J. Kendall, R. L. Dickerson, J. P. Giesy, and W. A. Suk, Eds.), pp. 1-16. SETAC Press, Pensacola, FL.
18. Mumtaz, M. M., and Durkin, P. R. (1992). A weight of evidence scheme for assessing interactions in chemical mixtures. Toxicol. Indust. Health 8, 377-406.
19. NRC (National Research Council) (1988). Complex Chemical Mixtures. Methods for In Vitro Toxicity Testing. Nat. Acad. Press, Washington, DC.
20. O'Flaherty, E. J. (1994). Physiologically based pharmacokinetic models in developmental toxicology. Risk Anal. 14, 605-11.
21. U. S. EPA (United States Environmental Protection Agency) (2000). Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures. EPA/630/R-00/002.
22. Yang, R. S. H. (2000). Health risks and preventive research strategy for deployed U.S. forces from toxicologic interactions among potentially harmful agents. In Strategies to Protect The Health of Deployed U.S. Forces: Assessing Health Risks to Deployed U.S. Forces, pp. 150-182. Nat. Acad. Press, Washington, DC.
23. Yang, R. S. H. (Ed.) (1994). Toxicology of Chemical Mixtures: Case Studies, Mechanisms, and Novel Approaches. Academic Press, San Diego.