Plk1 promotes nuclear translocation of human Cdc25C during prophase

EMBO Reports

Volumn 3, Issue 4, 2002, Pages 341-348

  Toyoshima Morimoto, Fumiko ^a   Taniguchi, Eri ^a   Nishida, Eisuke ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; MATURATION PROMOTING FACTOR; NOCODAZOLE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOTRANSFERASE; POLO LIKE KINASE 1; SERINE; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; HELA CELL; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROPHASE; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL NUCLEUS; CYCLIN B; HELA CELLS; HUMANS; PHOSPHORYLATION; PROPHASE; PROTEIN KINASES; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SERINE;

VERTEBRATA;

EID: 0036256260     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf069     Document Type: Article

References (40)

1. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
2. Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase
3. Cdc2 regulatory factors
4. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site
5. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase
6. Polo-like kinases: A team that plays throughout mitosis
7. Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding
8. MPF localization is controlled by nuclear export
9. Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal
10. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
11. Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis
12. Cyclins and their partners: From a simple idea to complicated reality
13. Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase
14. Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity
15. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts
16. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts
17. Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25
18. 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts
19. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
20. Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation
21. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
22. Principles of CDK regulation
23. Polo-like kinases: Positive regulators of cell division from start to finish
24. Mitotic kinases as regulators of cell division and its checkpoints
25. Universal control mechanism regulating onset of M-phase
26. 2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
27. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
28. Four-dimensional control of the cell cycle
29. Mitotic effects of a constitutively active mutant of the Xenopus Polo-like kinase Plx1
30. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
31. Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm
32. Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis
33. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C
34. 2 checkpoint
35. Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase
36. All aboard the cyclin train: Subcellular trafficking of cyclins and their CDK partners
37. Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1
38. 2 arrest in the Xenopus oocyte: A role for 14-3-3-mediated inhibition of Cdc25 nuclear import
39. Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites
40. DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding