Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination

Neuroscience Letters

Volumn 453, Issue 2, 2009, Pages 120-125

  Lindner, Maren ^a,b   Fokuhl, Jantje ^a   Linsmeier, Franziska ^a   Trebst, Corinna ^a   Stangel, Martin ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

Axonal damage; Cuprizone; Multiple sclerosis; Remyelination

Indexed keywords

CUPRIZONE; FAST BLUE; MYELIN PROTEIN; PROTEIN NOGO A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; C57BL 6 MOUSE; CENTRAL NERVOUS SYSTEM; CHRONIC DISEASE; CONTROLLED STUDY; DEMYELINATION; DIET RESTRICTION; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MICROGLIA; MOUSE; NERVE FIBER DEGENERATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMYELINIZATION;

ANIMALS; AXONS; CENTRAL NERVOUS SYSTEM; CUPRIZONE; DEMYELINATING DISEASES; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROGLIA; MONOAMINE OXIDASE INHIBITORS; MYELIN PROTEINS; NERVE FIBERS, MYELINATED; OLIGODENDROGLIA;

EID: 61449187249     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.02.004     Document Type: Article

References (25)

1. Armstrong R.C., Le T.Q., Flint N.C., Vana A.C., and Zhou Y.X. Endogenous cell repair of chronic demyelination. J. Neuropathol. Exp. Neurol. 65 (2006) 245-256
2. Bjartmar C., and Trapp B.D. Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Curr. Opin. Neurol. 14 (2001) 271-278
3. Bjartmar C., Wujek J.R., and Trapp B.D. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J. Neurol. Sci. 206 (2003) 165-171
4. Chang A., Tourtellotte W.W., Rudick R., and Trapp B.D. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N. Engl. J. Med. 346 (2002) 165-173
5. Ferguson B., Matyszak M.K., Esiri M.M., and Perry V.H. Axonal damage in acute multiple sclerosis lesions. Brain 120 (1997) 393-399
6. Geddes J.F., Vowles G.H., Beer T.W., and Ellison D.W. The diagnosis of diffuse axonal injury: implications for forensic practice. Neuropathol. Appl. Neurobiol. 23 (1997) 339-347
7. Gentleman S.M., Nash M.J., Sweeting C.J., Graham D.I., and Roberts G.W. Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury. Neurosci. Lett. 160 (1993) 139-144
8. Hiremath M.M., Saito Y., Knapp G.W., Ting J.P., Suzuki K., and Matsushima G.K. Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice. J. Neuroimmunol. 92 (1998) 38-49
9. Irvine K.A., and Blakemore W.F. Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice. J. Neuroimmunol. 175 (2006) 69-76
10. Irvine K.A., and Blakemore W.F. Remyelination protects axons from demyelination-associated axon degeneration. Brain 131 (2008) 1464-1477
11. Kornek B., Storch M.K., Weissert R., Wallstroem E., Stefferl A., Olsson T., Linington C., Schmidbauer M., and Lassmann H. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am. J. Pathol. 157 (2000) 267-276
12. Kuhlmann T., Lingfeld G., Bitsch A., Schuchardt J., and Bruck W. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 125 (2002) 2202-2212
13. Kuhlmann T., Remington L., Maruschak B., Owens T., and Bruck W. Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions. J. Neuropathol. Exp. Neurol. 66 (2007) 238-246
14. Lassmann H., Bruck W., and Lucchinetti C. Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol. Med. 7 (2001) 115-121
15. Lindner M., Heine S., Haastert K., Garde N., Fokuhl J., Linsmeier F., Grothe C., Baumgartner W., and Stangel M. Sequential myelin protein expression during remyelination reveals fast and efficient repair after central nervous system demyelination. Neuropathol. Appl. Neurobiol. 34 (2008) 105-114
16. Mason J.L., Langaman C., Morell P., Suzuki K., and Matsushima G.K. Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre. Neuropathol. Appl. Neurobiol. 27 (2001) 50-58
17. Mason J.L., Toews A., Hostettler J.D., Morell P., Suzuki K., Goldman J.E., and Matsushima G.K. Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions. Am. J. Pathol. 164 (2004) 1673-1682
18. Mathey E.K., Derfuss T., Storch M.K., Williams K.R., Hales K., Woolley D.R., Al Hayani A., Davies S.N., Rasband M.N., Olsson T., Moldenhauer A., Velhin S., Hohlfeld R., Meinl E., and Linington C. Neurofascin as a novel target for autoantibody-mediated axonal injury. J. Exp. Med. 204 (2007) 2363-2372
19. Matsushima G.K., and Morell P. The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol. 11 (2001) 107-116
20. Owens T. The enigma of multiple sclerosis: inflammation and neurodegeneration cause heterogeneous dysfunction and damage. Curr. Opin. Neurol. 16 (2003) 259-265
21. Petzold A. Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss. J. Neurol. Sci. 233 (2005) 183-198
22. Rodriguez M. A function of myelin is to protect axons from subsequent injury: implications for deficits in multiple sclerosis. Brain 126 (2003) 751-752
23. Skripuletz T., Lindner M., Kotsiari A., Garde N., Fokuhl J., Linsmeier F., Trebst C., and Stangel M. Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent. Am. J. Pathol. 172 (2008) 1053-1061
24. Trapp B.D., Ransohoff R., and Rudick R. Axonal pathology in multiple sclerosis: relationship to neurologic disability. Curr. Opin. Neurol. 12 (1999) 295-302
25. Wolswijk G. Oligodendrocyte precursor cells in chronic multiple sclerosis lesions. Mult. Scler. 3 (1997) 168-169