Novel role of AMP-activated protein kinase signaling in cigarette smoke induction of IL-8 in human lung epithelial cells and lung inflammation in mice

Free Radical Biology and Medicine

Volumn 50, Issue 11, 2011, Pages 1492-1502

  Tang, Gau Jun ^a   Wang, Hsin Yi ^a   Wang, Jen Ying ^a   Lee, Chih Chieh ^a   Tseng, Hsu Wen ^a   Wu, Yuh Lin ^a   Shyue, Song Kun ^b   Lee, Tzong Shyuan ^a   Kou, Yu Ru ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

AMP activated protein kinase; Cigarette smoke; Free radicals; IL 8; Lung inflammation; MIP 2 ; NADPH oxidase; Reactive oxygen species

Indexed keywords

3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; ACETYLCYSTEINE; APOCYNIN; CIGARETTE SMOKE; COMPOUND C; CXCL2 CHEMOKINE; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ACETOPHENONES; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL LINE; HUMANS; INTERLEUKIN-8; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NADPH OXIDASE; PLANT EXTRACTS; PNEUMONIA; PYRAZOLES; PYRIMIDINES; RESPIRATORY MUCOSA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMOKING;

MUS;

EID: 79955594658     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.02.030     Document Type: Article

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