Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 3007-3011

  You, Lei ^a   Cho, Eun Jeong ^a   Leavitt, John ^a   Ma, Li Chung ^b   Montelione, Gaetano T ^b,c   Anslyn, Eric V ^a   Krug, Robert M ^a   Ellington, Andrew ^a   Robertus, Jon D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Fluorescence polarization; Influenza A virus; NS1A protein; Quinoxaline derivatives

Indexed keywords

DOUBLE STRANDED RNA; PROTEIN INHIBITOR; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN NS1A; VIRUS PROTEIN NS1A INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FLUORESCENCE POLARIZATION IMMUNOASSAY; GROWTH INHIBITION; IC 50; INFLUENZA VIRUS A; INTERCALATION COMPLEX; NONHUMAN; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; VIRAL NONSTRUCTURAL PROTEINS;

INFLUENZA A VIRUS;

EID: 79955568575     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.042     Document Type: Article

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