Synthesis and antibacterial activity of hydrolytically stable (-)-epicatechin gallate analogues for the modulation of β-lactam resistance in Staphylococcus aureus

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 10, 2005, Pages 2633-2635

  Anderson, James C ^a   Headley, Catherine ^a   Stapleton, Paul D ^b   Taylor, Peter W ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

( ) Epicatechingallate analogues; MRSA; Lactam antibiotics

Indexed keywords

BETA LACTAM ANTIBIOTIC; EPICATECHIN GALLATE; FLAVONOID; METICILLIN; OXACILLIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STEREOCHEMISTRY;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 18144400595     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.063     Document Type: Article

References (19)

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17. These were assigned based on the coupling constants their C-2H protons as before (Ref. 8), 10 (natural 3R stereochemistry) C-2H (δ 5.09, d, J = 2.2 Hz) and 11 (3S) C-2H (δ 4.70, m, J = 7.6 Hz)
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19. 4 colony-forming units (cfu) in 100 μL of Mueller-Hinton broth (Oxoid, Basingstoke, UK) supplemented with 2% w/v NaCl. Doubling dilutions of oxacillin were employed. MIC values were recorded after incubation of the trays at 35°C for 24 h; S. aureus ATCC29213 was used as the standard. The intrinsic anti-staphylococcal activity of compounds was also evaluated using these methods