Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate

Journal of Medicinal Chemistry

Volumn 51, Issue 7, 2008, Pages 2018-2026

  Sánchez del Campo, Luís ^a   Otón, Francisco ^a   Tárraga, Alberto ^a   Cabezas Herrera, Juan ^b   Chazarra, Soledad ^a   Rodríguez López, José Neptuno ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 O (3,4,5 TRIMETHOXYBENZOYL)EPICATECHIN; ANTIOXIDANT; CATECHIN; DIHYDROFOLATE REDUCTASE; EPICATECHIN; EPICATECHIN GALLATE; ESTER DERIVATIVE; METHOTREXATE; PIRITREXIM; TRIMETREXATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL LINE; CELL PROLIFERATION; DRUG ACTIVITY; DRUG BINDING; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MELANOMA; STRUCTURE ACTIVITY RELATION;

ANTIOXIDANTS; CATECHIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FOLIC ACID; FOLIC ACID ANTAGONISTS; GENE EXPRESSION PROFILING; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MODELS, MOLECULAR; MOLECULAR STRUCTURE; NADP; RNA, MESSENGER; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TEA; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE; TIME FACTORS;

EID: 41849135027     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701346h     Document Type: Article

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