Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase

Journal of Biological Chemistry

Volumn 286, Issue 18, 2011, Pages 16491-16503

  Baljuls, Angela ^a   Mahr, Regina ^a   Schwarzenau, Inge ^a   Müller, Thomas ^a   Polzien, Lisa ^a   Hekman, Mirko ^a   Rapp, Ulf R ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC ACTIVITY; CENTRAL COMPONENT; DEPHOSPHORYLATIONS; HYPERPHOSPHORYLATION; ISOFORMS; KINASE ACTIVITY; KINASE DOMAINS; PLASMA MEMBRANES; PROTOMERS; RECYCLING PROCESS; SCAFFOLD PROTEIN; STRUCTURAL REARRANGEMENT; TETRAPEPTIDE;

ARGININE; CATALYST ACTIVITY; CELL MEMBRANES; DIMERIZATION; ENZYMES; PHOSPHORYLATION; SCAFFOLDS (BIOLOGY);

AMINO ACIDS;

A RAF KINASE; ARGININE; B RAF KINASE; C RAF PROTEIN; ISOENZYME; LYSINE; RAF PROTEIN; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CELL MEMBRANE; CONTROLLED STUDY; CRYSTALLIZATION; DIMERIZATION; ENZYME ACTIVITY; ENZYME DEFECT; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; RESIDUE ANALYSIS; STRUCTURAL HOMOLOGY;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MUTATION, MISSENSE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RAF KINASES;

EID: 79955545442     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.194167     Document Type: Article

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