Identification of key residues in the A-Raf kinase important for phosphoinositide lipid binding specificity

Biochemistry

Volumn 44, Issue 9, 2005, Pages 3432-3440

  Johnson, Lindsey M ^a,b   James, Kristy M ^a   Chamberlain, M Dean ^a,b   Anderson, Deborah H ^a,b  

^a SASKATCHEWAN CANCER AGENCY   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ALCOHOLS; BIOLOGICAL MEMBRANES; CARBOXYLIC ACIDS; CELLS; COMPLEXATION; PHOSPHOLIPIDS; PHOSPHORUS COMPOUNDS; SIGNAL PROCESSING;

A-RAF KINASE; CELLULAR SIGNAL TRANSDUCTION; EXTERNAL STINULI; PHOSPHORYLATION; RELOCALIZATION;

ENZYME KINETICS;

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,5 BIPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLSERINE; RAF PROTEIN; RAS PROTEIN; TRIPHOSPHOINOSITIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL MEMBRANE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; HUMAN; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO ACIDS; DOWN-REGULATION; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS A-RAF; PROTO-ONCOGENE PROTEINS C-RAF; SUBSTRATE SPECIFICITY;

EID: 14644390241     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0487692     Document Type: Article

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