Hypermethylation of tumor-related genes in tunisian patients with gastric carcinoma: Clinical and biological significance

Journal of Surgical Oncology

Volumn 103, Issue 7, 2011, Pages 687-694

  Ben Ayed Guerfali, Dorra ^a   Benhaj, Khemais ^a   Khabir, Abdelmajid ^b   Abid, Mohamed ^b   Bayrouti, Mohamed Issam ^b   Sellami Boudawara, Tahia ^b   Gargouri, Ali ^a   Mokdad Gargouri, Raja ^a  

^a CENTRE DE BIOTECHNOLOGIE DE SFAX   (Tunisia)

^b HABIB BOURGUIBA HOSPITAL   (Tunisia)

Author keywords

gastric carcinoma; methylation; prognosis

Indexed keywords

CYCLOOXYGENASE 2; RETINOIC ACID RECEPTOR;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER SURVIVAL; CLINICAL FEATURE; DNA METHYLATION; FEMALE; GENE FREQUENCY; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; STOMACH CARCINOMA; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS REGULATORY PROTEINS; CADHERINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CARCINOMA; CYCLOOXYGENASE 2; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENES, P16; GENETIC MARKERS; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROGNOSIS; PROMOTER REGIONS, GENETIC; PROPORTIONAL HAZARDS MODELS; RECEPTORS, RETINOIC ACID; STOMACH NEOPLASMS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUNISIA; YOUNG ADULT;

EID: 79955482440     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21875     Document Type: Article

References (37)

1. Parkin DM, Bray F, Ferlay J, et al.: Global cancer statistics. CA Cancer J Clin 2005; 55: 74-108.
2. Hsairi M, Fakfakh R, Ben Abdallah M, et al.: Assessment of cancer incidence in Tunisia. Tunis Med 2002; 80: 57-64.
3. Lauren P,: The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31-49.
4. Issa JP,: CpG island methylator phenotype in cancer. Nat Rev Cancer 2004; 4: 988-993.
5. Baylin SB, Herman JG, DNA hypermethylation in tumorigenesis: Epigenetics joins genetics. Trends Genet 2000; 16: 168-174. (Pubitemid 30169152)
6. Esteller M,: Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. Br J Cancer 2006; 94: 179-183. (Pubitemid 43151531)
7. Toyota M, Ahuja N, Suzuki H, et al.: Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res 1999; 59: 5438-5442. (Pubitemid 29526452)
8. Kang GH, Lee S, Kim WH, et al.: Epstein-Barr virus positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 2002; 160: 787-794. (Pubitemid 34224568)
9. Kusano M, Toyota M, Suzuki H, et al.: Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus. Cancer 2006; 106: 1467-1479.
10. Kim Y, Jong HS, Jung Y, et al.: DNA hypermethylation in gastric cancer. Aliment Pharmacol Ther 2004; 20: 131-142. (Pubitemid 39120285)
11. Camargo Ferrasi A, Pinheiro NA, Barem Rabenhorst SH, et al.: Helicobacter pylori and EBV in gastric carcinomas: Methylation status and microsatellite instability. World J Gastroenterol 2010; 16: 312-319.
12. Chong JM, Sakuma K, Sudo M, et al.: Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virus. Cancer Sci 2003; 94: 76-80. (Pubitemid 36575862)
13. Liggett WH, Sidransky JD,: Role of the p16 tumor suppressor gene in cancer. J Clin Oncol 1998; 16: 1197-1206.
14. Raveh T, Kimchi A,: DAP kinase: A pro-apoptotic gene that functions as a tumor suppressor. Exp Cell Res 2001; 264: 185-192. (Pubitemid 32989091)
15. Weyden L, Adams DJ,: The Ras-association domain family (RASSF) members and their role in human tumourigenesis. Biochim Biophys Acta 2007; 1776: 58-85. (Pubitemid 47332074)
16. Chambon P,: The retinoid signaling pathway: Molecular and genetic analyses. Semin Cell Biol 1994; 5: 115-125. (Pubitemid 124003277)
17. Fendri A, Masmoudi A, Khabir A, et al.: Inactivation of RASSF1A, RARβ2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma. Cancer Biol Ther 2009; 8: 1-8.
18. Hayashi K, Yokozaki H, Goodison S, et al.: Inactivation of retinoic acid receptor b by promoter CpG hypermethylation in gastric cancer. Differentiation 2001; 68: 13-21. (Pubitemid 34203524)
19. Birchmeier W, Behrens J,: Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994; 1198: 11-26. (Pubitemid 24159061)
20. Ksiaa F, Ziadi S, Amara K, et al.: Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma. Clin Chim Acta 2009; 404: 128-133.
21. Sobin LH, Fleming ID,: TNM classification of malignant tumors, fifth edition. Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer 1997; 80: 1803-1804.
22. Fukayama M, Hayashi Y, Iwasaki Y, et al.: Epstein-Barr virus infection of the stomach. Lab Invest 1994; 71: 73-81.
23. Herman JG, Graff JR, Myohanen S, et al.: Methylation-specific PCR. A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93: 9821-9826. (Pubitemid 26296693)
24. Tamura G,: Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. World J Gastroenterol 2006; 12: 192-198. (Pubitemid 43336916)
25. Kato K, Iida S, Uetake H, et al.: Methylated TMS1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer. Int J Cancer 2008; 122: 603-608. (Pubitemid 350308952)
26. Takaoka AS, Kakiuchi H, Itoh F, et al.: Infrequent alterations of the p16 (MTS-1) gene in human gastric cancer. Tumour Biol 1997; 18: 95-103. (Pubitemid 27096397)
27. Gunther T, Schneider-Stock R, Pross M, et al.: Alteration of p16/MTS1-tumor suppressor gene in gastric cancer. Pathol Res Pract 1998; 194: 809-813. (Pubitemid 29012241)
28. Shim YH, Kang GH, Ro JY,: Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas. Lab Invest 2000; 80: 689-695. (Pubitemid 30340653)
29. Ding Y, Le XP, Zhang QX, et al.: Methylation and mutation analysis of p16 gene in gastric cancer. World J Gastroenterol 2003; 9: 423-426. (Pubitemid 36372099)
30. Lee YY, Kang SH, Seo JY, et al.: Alterations of p16INK4A and p15INK4B genes in GC. Cancer 1997; 80: 1889-1896.
31. Sun Y, Deng D, You WC, et al.: Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study. Clin Cancer Res 2004; 10: 5087-5093. (Pubitemid 39099783)
32. Luo D, Zhang B, Lv L, et al.: Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas. Lab Invest 2006; 86: 591-598. (Pubitemid 43780440)
33. Etoh T, Kanai Y, Hirohashi S, et al.: Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol 2004; 164: 689-699. (Pubitemid 38364682)
34. Hino R, Uozaki H, Fukayama M, et al.: Survival advantage of EBV-associated gastric carcinoma: Surviving up-regulation by viral latent membrane protein 2A. Cancer Res 2008; 68: 1427-1435. (Pubitemid 351346850)
35. Xu XC,: Tumor-suppressive activity of retinoic acid receptor-β in cancer. Cancer Lett 2007; 253: 14-24.
36. Li M, Song S, Lippman SM, et al.: Induction of retinoic acid receptor beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. Oncogene 2002; 21: 411-418. (Pubitemid 34123803)
37. Zha S, Yegnasubramanian V, Nelson WG, et al.: Cyclooxygenases in cancer: Progress and perspective. Cancer Lett 2004; 215: 1-20. (Pubitemid 39221453)