Inactivation of RASSF1A, RARβ2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma

Cancer Biology and Therapy

Volumn 8, Issue 5, 2009, Pages 444-451

  Fendri, Ali ^a   Masmoudi, Asma ^a   Khabir, Abdelmajid ^b   Sellami Boudawara, Tahia ^b   Daoud, Jamel ^b   Frikha, Mounir ^b   Ghorbel, Abdelmonem ^b   Gargouri, Ali ^a   Mokdad Gargouri, Raja ^a  

^a CENTRE DE BIOTECHNOLOGIE DE SFAX   (Tunisia)

^b HABIB BOURGUIBA HOSPITAL   (Tunisia)

Author keywords

DAP kinase; IHC; Methylation specific polymerase chain reaction; RT PCR; Nasopharyngeal carcinoma; RAR 2; RASSF1A

Indexed keywords

CYCLOOXYGENASE 2; DEATH ASSOCIATED PROTEIN KINASE; PROTEIN P53; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RETINOIC ACID RECEPTOR BETA; APOPTOSIS REGULATORY PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; DEATH-ASSOCIATED PROTEIN KINASE; PTGS2 PROTEIN, HUMAN; RASSF1 PROTEIN, HUMAN; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR, BETA2, HUMAN; TP53 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADULT; ARTICLE; CORRELATION ANALYSIS; DAP KINASE GENE; DNA METHYLATION; EPIGENETICS; FEMALE; GENE; GENE INACTIVATION; GENE SILENCING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; NASOPHARYNX CARCINOMA; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RARBETA2 GENE; RASSFIA GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ADOLESCENT; AGED; ANIMAL; CHILD; GENETICS; METABOLISM; MIDDLE AGED; NASOPHARYNX TUMOR; PATHOLOGY; XENOGRAFT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CHILD; CYCLOOXYGENASE 2; DNA METHYLATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; PROMOTER REGIONS, GENETIC; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 66149125699     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.5.7686     Document Type: Article

References (38)

1. Nicholls JM, Agathanggelou A, Fung K, Zeng X, Niedobitek G. The association of squamous cell carcinomas of the nasopharynx with Epstein-Barr virus shows geographical variation reminiscent of Burkitt's lymphoma. J Pathol 1997; 183:164-168 (Pubitemid 27436019)
2. Busson P, Keryer C, Ooka T, Corbex M. EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies. Trends Microbiol 2004; 12:356-360 (Pubitemid 38987821)
3. Kammoun M, Vogt-Hoerner G, Mourali N. Tumors of the nasopharynx in Tunisia: An anatomic and clinical study based on 143 cases. Cancer 1974; 33:184-191
4. Khabir A, Sellami A, Sakka M, Ghorbel AM, Daoud J, Frikha M, et al. Contrasted frequencies of p53 accumulation in the two age groups of North African nasopharyngeal carcinomas. Clin Cancer Res 2000; 6:3932-3936
5. Chang ET, Hans-Olov A. The Enigmatic Epidemiology of Nasopharyngeal Carcinoma. Cancer Epidemiol Biomarkers Prev 2006; 15:335-339
6. Feng BJ, Jalbout M, Ben Ayoub W, Khyatti M, Dahmoul S, Ayad M, et al. Dietary risk factors for nasopharyngeal carcinoma in Maghrebian countries. Int J Cancer 2007; 121:1550-1555
7. Lo KW, To KF, Huang DP. Focus on nasopharyngeal carcinoma. Cancer Cell 2004; 39:2349-2354
8. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3:415-428 (Pubitemid 34587077)
9. Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 1994; 91:9700-9704
10. Di Vinci A, Perdelli L, Banelli B, Salvi S, Casciano I, Gelvi I, et al. p16INK4 a promoter methylation and protein expression in breast fibroadenoma and carcinoma. Int J Cancer 2005; 114:414-421 (Pubitemid 40279962)
11. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 1998; 95:6870-6875
12. Lee WH, Morton PA, Epstein JI, Brooks JD, Campbell PA, Bova GS, et al. Cytidine methylation of regulatory sequences near the - class glutathione S-transferase gene accompanies human prostatic carcinogenesis. Proc Natl Acad Sci USA 1994; 91:11733-11737
13. Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA-methyltransferase by promoter hypermethylation is a common event in multiple human neoplasia. Cancer Res 1999; 59:793-797 (Pubitemid 29086728)
14. Simpson DJ, Clayton RN, Farrell WE. Preferential loss of Death Associated Protein kinase expression in invasive pituitary tumours is associated with either CpG island methylation or homozygous deletion. Oncogene 2000; 21:1217-1224 (Pubitemid 34185238)
15. Katzenellenbogen RA, Baylin SB, Herman JG. Hypermethylation of the DAP-kinase CpG island is a common alternation in B-cell malignancies. Blood 1999; 93:4347-4353 (Pubitemid 29279278)
16. Lo KW, Peter-Teo ML, Bik-Yu Hui A, To K, Yuen-Shan T. High Resolution Allelotype of Microdissected Primary Nasopharyngeal Carcinoma. Can Res 2000; 60:3348-3353 (Pubitemid 30482144)
17. Dammann R, Li C, Yoon JH, Chin PL, Bates S, Pfeifer GP. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 2000; 25:315-319 (Pubitemid 30437320)
18. Lillian SC, LO KW, Kwong J, TO KF, Tsang KS, Lam CW, et al. RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma. Int J Cancer 2004; 109:839-847
19. Lo KW, Kwong J, Hui AB, Chan SY, To KF, Chan AS, et al. High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma. Cancer Res 2001; 61:3877-3881
20. Ueki T, Toyota M, Sohn T, Yeo CJ, Issa JPJ, Hruban RH, et al. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res 2000; 60:1835-1839.
21. Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, et al. Promoter methylation and silencing of the retinoid acid receptor-β gene in lung carcinomas. J Natl Cancer Inst 2000; 92:1303-1307
22. Yang Q, Mori I, Shan L, Nakamura M, Nakamura Y, Utsunomiya H, et al. Biallelic inactivation of retinoic acid receptor β2 gene by epigenetic change in breast cancer. Am J Pathol 2001; 158:299-303
23. Kwong J, Lo KW, To KF, Teo PM, Johnson PJ, Huang DP. Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin Cancer Res 2002; 8:131-137 (Pubitemid 34101468)
24. Kong WJ, Zhang S, Guo CK, Wang YJ, Chen X, Zhang SL, et al. Effect of methylation-associated silencing of the death-associated protein kinase gene on nasopharyngeal carcinoma. Anticancer Drugs 2006; 17:251-259
25. th edn. Wiley-Liss, New York 1997; 25-32.
26. Herman JG, Graff JR, Myo hanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93:9921-9926
27. Palmisano WA, Divine KK, Saccomanno G, Gilliland FD, Baylin SB, Herman JG, et al. Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res 2000; 60:5954-5958
28. Agathanggelou A, Cooper WN, Latif F. Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. Cancer Res 2005; 65:3497-3508 (Pubitemid 40616319)
29. Dammann R, Schagdarsurengin U, Seidel C, Strunnikova M, Rastetter M, Baier K, et al. The tumor suppressor RASSF1A in human carcinogenesis: An update. Histol Histopathol 2005; 20:645-663 (Pubitemid 40468282)
30. Wong TS, Tang KC, Kwong DL, Sham JS, Wei WI, Kwong YL, et al. Differential gene methylation in undifferentiated nasopharyngeal carcinoma. Int J Oncol 2003; 22:869-874
31. Yi Lo PH, Xie D, Chi Chan K, Xu FP, Kuzmin I, Lerman M, et al. Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage. Cancer Lett 2007; 257:199-205.
32. Judit O, Aliz J, Eva R, Helga E, Mihaly B, Orsolya C, et al. RARβ2 suppression in head and neck squamous cell carcinoma correlates with site, histology and age. Oncology Report 2007; 18:105-112
33. Xu XC. Tumor-suppressive activity of retinoic acid receptor-β in cancer Cancer Lett 2007; 253:14-24. (Pubitemid 46874724)
34. Li M, Song S, Lippman SM, Zhang XK, Liu X, Lotan R, et al. Induction of retinoic acid receptor beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. Oncogene 2002; 21:411-418
35. Zha S, Yegnasubramanian V, Nelson WG, Isaacs WB, De Marzo AM. Cyclooxygenases in cancer: progress and perspective. Cancer Lett 2004; 215:1-20. (Pubitemid 39221453)
36. Inbal B, Cohen O, Polak-Charcon S, Kopolovic J, Vadai E, Eisenbach L, et al. DAP kinase links the control of apoptosis to metastasis. Nature 1997; 390:180-184
37. Sanchez-Cespedes M, Esteller M, Wu L, Nawroz-Danish H, Yoo GH, Koch WM, et al. Gene Promoter Hypermethylation in Tumors and Serum of Head and Neck Cancer Patients. Cancer Res 2000; 60:892-895
38. ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol 2001; 3:1-7.