Methylation and mutation analysis of p16 gene in gastric cancer

World Journal of Gastroenterology

Volumn 9, Issue 3, 2003, Pages 423-426

  Ding, Yi ^a   Le, Xiao Ping ^a   Zhang, Qin Xian ^a   Du, Peng ^b  

^a ZHENGZHOU UNIVERSITY   (China)

^b Henan Key Lab of Molecular Medicine   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16; RESTRICTION ENDONUCLEASE;

ARTICLE; CANCER GROWTH; CANCER TISSUE; CONTROLLED STUDY; DNA METHYLATION; EXON; GENE DELETION; GENE FREQUENCY; GENE MUTATION; HOMOZYGOTE; HUMAN; HUMAN TISSUE; MUTATIONAL ANALYSIS; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; STOMACH MUCOSA;

EID: 0037349716     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v9.i3.423     Document Type: Article

References (32)

1. Yskoob J, Fan XG, Hu GL, Zhang Z. DNA methylation and carcinogenesis in digestive neoplasms. World J Gastroenterol 1998; 4: 174-177
2. Pollock PM, Pearson JV, Hayward NK. Compilation of somatic mutation of the CDKN2 gene in human cancers: Non random distribution of base substitutions. Genes Chromosomes Cancers 1996; 15: 77-88.
3. Hayashi K, Metzger R, Salonga D, Danenberg K, Leichman LP, Fink U, Sendler A, Kelsen D, Schwartz GK, Groshen S, Lenz HJ, Danenberg PV. High frequency of simultaneous loss of p16 and p16 beta gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach. Oncogene 1997; 15: 1481-1488
4. Song ZY, Xu RZ, Qian KD, Tang XQ, Zhao XY, Lin M. Abnormal expression of p16/CDKN2 gene in human gastric carcinoma. Xin Xiaohua Bingxue Zazhi 1997; 5: 139-140
5. Igaki H, Sasaki H, Tachimori Y, Kato H, Watanabe H, Kimura T, Harada Y, Sugimura T, Terada M. Mutation frequency of the p16/CDK2 gene in primary cancer in the upper digestive tract. Cancer Res 1995; 55: 3421-3423
6. Okamoto A, Hussain SP, Hagiwara K, Spillare EA, Rusin MR, Demetrick DJ, Serrano M, Hannon GJ, Shiseki M, Zariwala M. Mutations in the p16INK4/MTS1/CNKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res 1995; 55: 1448-1451
7. Mori T, Miura K, Aoki T, Nishihira T, Mori S, Nakamura Y. Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res 1994; 54: 3396-3397
8. Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM, Jones PA. Methylation of the 5′ CpG island of the p16/CDK2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 1995; 55: 4531-4535
9. Zhang J, Lai MD, Chen J. Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa. World J Gastroenterol 1999; 5: 451-454
10. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of oestrogen receptor CpG island links aging and neoplasia in human colon. Nat Genet 1994; 7: 536-540
11. Zingg JM, Jones PA. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis 1997; 18: 869-882
12. Wang B, Shi LC, Zhang WB, Xiao CM, Wu JF, Dong YM. Expression of tumor suppressor gene p16 in gastric cancer and precancerous lesions. Shijie Huaren Xiaohua Zazhi 2001; 9: 39-42
13. Zhou Y, Gao SS, Li YX, Fang ZM, Zhao X, Qi YJ, Wei JP, Zou JX, Liu G, Jiao LH, Bai YM, Wang LD. Tumor suppressor gene p16 and Rb expression in gastric cardia precancerous lesions from subjects at a high incidence area in northern China. World J Gastroenterol 2002; 8: 423-425
14. He XS, Su Q, Chen ZC, He XT, Long ZF, Ling H, Zhang LR. Expression, deletion and mutation of p16 gene in human gastric cancer. World J Gastroenterol 2001; 7: 515-521
15. Wei TY, Wei MX, Yang SM. Expression of cyclin D1 P16 and Rb protein in gastric cancer. Shijie Huaren Xiaohua Zazhi 2000; 8: 234-235
16. Zhu ZY, Tian X, Wang X, Yang XL. Mutation of p16 and APC gene in gastric cancer. Shijie Huaren Xiaohua Zazhi 2000; 8: 1418-1419
17. Yang SM, Yang LS, Li L, Deng LY, Wang CY, Yuan XB, Shen XD. Methylation of MTS1/P16 gene and expression of P16 protein in gastric cancer. Shijie Huaren Xiaohua Zazhi 2000; 8: 1427-1429
18. Zhao Y, Zhang XY, Shi XJ, Hu PZ, Zhang CS, Ma FC. Expression of P16, P53 and proliferating cell nuclear antigen in gastric cancer. Shijie Huaren Xiaohua Zazhi 1999; 7: 246-248
19. Li GX, Li GQ, Zhao CZ, Xu GL. Relationship between telomerase hTRT and the expression of tumor suppressor gene p53 and p16. Shijie Huaren Xiaohua Zazhi 2002; 10: 591-593
20. Jiang YX, Zhao MY, Geng M, Chao YC, Wang XY. Expression of P16, cerB-2 protein in gastric tumor. Shijie Huaren Xiaohua Zazhi 2002; 10: 1050-1051
21. Yang ZL, Li YG, Huang YF, Wang QW. Expression of cyclin D1, CDK4, P16 and Rbin gastric cancer. Shijie Huaren Xiaohua Zazhi 2000; 8: 362-363
22. Wang GT. Progression in the study on gastric precancerous lesions and its reversion. Shijie Huaren Xiaohua Zazhi 2000; 8: 1-4
23. Kempster S, Phillips WA, Baindur-Hudson S, Thomas RJ, Dow C, Rockman SP. Methylation of exon 2 of p16 is associated with late stage oesophageal cancer. Cancer Lett 2000; 150: 57-62
24. Yi J, Wang ZW, Cang H, Chen YY, Zhao R, Yu BM, Tang XM. P16 gene methylation in colorectal cancers associated with Duke's staging. World J Gastroenterol 2001; 7: 722-725
25. Hui AM, Shi YZ, Li X, Takayama T, Makuuchi M. Loss of p16 (INK4) protein, alone and together with loss of retinoblastoma protein, correlate with hepatocellular carcinoma progression. Cancer Lett 2000; 154: 93-99
26. Lin SC, Chang KW, Chang CS, Liu TY, Tzeng YS, Yang FS, Wong YK. Alterations of p16/MTS1 gene in oral squamous cell carcinomas from Taiwanese. J Oral Pathol Med 2000; 29: 159-166
27. Liggett WH Jr, Sidransky D. Role of the p16 tumor suppressor gene in cancer. J Clinical Oncol 1998; 16: 1197-1206
28. Lu YY, Gao CF, Cui JQ. Deletion and down-regulation of mts1/p16 gene in human gastric cancer. Zhonghua Zhongliu Zazhi 1996; 18: 189-191
29. Wu MS, Shun CT, Sheu JC, Wang HP, Wang JT, Lee WJ, Chen CJ, Wang TH, Lin JT. Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: With respect to histological subtypes and stages. J Gastroenterol Hepatol 1998; 13: 305-310
30. Jiang HX, Liu ZM, Zhuang YQ, Yang DH, Jiang YQ, Li JQ. Homologous deletion of p16 gene in human gastric carcinoma. Huaren Xiaohua Zazhi 1998; 6: 934-935
31. Lee YY, Kang SH, Seo JY, Jung CW, Lee KU, Choe KJ, Kim BK, Kim NK, Koeffler HP, Bang YJ. Alterations of p16INK4A and p15INK4B genes in gastric carcinomas. Cancer 1997; 15: 1889-1896
32. Tang SH, Luo HS. Aberration of p16 gene and p18 gene in gastric carcinoma. Shijie Huaren Xiaohua Zazhi 2001; 9: 91-92