Infrequent alterations of the p16 (mts-1) gene in human gastric cancer

Tumor Biology

Volumn 18, Issue 2, 1997, Pages 95-103

  Takaoka, Asako Suzuki ^a   Kakiuchi, Hideki ^a   Itoha, Fumio ^a   Hinoda, Yuji ^a   Kusano, Masanobu ^b   Ohara, Masanori ^b   Tsukakoshi, Hiromoto ^b   Hosokawa, Masao ^b   Imai, Kohzoh ^a  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

^b Keiyukai Sapporo Hospital   (Japan)

Author keywords

Gastric cancer; Multiple tumor suppressor gene 1; P16; Polymerase chain reaction single strand conformation polymorphism; Reverse transcription polymerase chain reaction

Indexed keywords

PROTEIN P16;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; TUMOR SUPPRESSOR GENE;

EID: 0031024010     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1159/000218020     Document Type: Article

References (33)

1. Okamoto A, Demctric DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Serrano M, Beach DH, Harris CC: Mutation and altered expression of pl6INK4B in human cancer, Proc Natl Acad Sci USA 1994;91:11045-11049.
2. Serrano M, Hannon GJ, Beach D: A new regulatory motif involved in cell-cycle control causing specific inhibition of cyclin D/CDK4, Nature 1993;366:704-707.
3. Bates S, Bonetta L, MacAllen D, Parry D, Holder A, Dickson C, Peters G: CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin Dl, Oncogene 1994;9:71-79.
4. Kamb A, Gruis NA, Weaver FJ, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS III, Johnson BE, Skolnick MH: A cell cycle regulator potentially involved in genesis of many tumor types, Science 1994; 264:436-440.
5. INK4a tumor suppressor protein, Cancer Res 1995:55:2503- 2506.
6. Hirama T, Koeffler H: Role of the cyclin-dependent kinase inhibitors in the development cancer, Blood 1995;86:841-854.
7. reatecj CDK6 inhibitor, correlates with wild-type pRb function, Genes Dev 1995;8:2939- 2952.
8. Jen J, Harper JW, Bigner SH, Bigncr DD, Papadopoulos N, Markowitz S, Willson JKV, Kinzler KW, Vogel-stein B: Deletion of p 16 and pi5 genes in brain tumors, Cancer Res 1994;54:6353-6358.
9. Schmidt EE, Ichimura K, Reifen-bergcr G, Collins VP: CDKN2 (pi6/ MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas, Cancer Res 1994; 54: 6321-6324.
10. Nishikawa R, Furnari FB, Lin H, Arap W, Berger MS, Cavenec WK, Huaug HJS: Loss of pl6/INK4 expression is frequent in high grade gliomas, Cancer Res 1995;55:1941- 1945.
11. Zhang SH, Klein-Szanto AJ, Sauter ER, Shafarenko M, Mitsunaga S, Nobori T, Carson DA, Ridge JA, Goodrow TL: Higher frequency of alterations in the pl6-CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck, Cancer Res 1994;54: 5050-5053.
12. Mori T, Miura K, Aoki T, Nishihara T, Mori S, Nakamura Y: Frequent somatic mutation of the MTS1/ CDK4I (multiple tumor suppressor/ cyclin-dependcnt kinase 4 inhibitor) gene in esophageal squamous cell carcinoma, Cancer Res 1994;54: 3396-3397.
13. Zhou X, Tarmin L, Yin J, Jiang HY, Suzuki H, Rliyu MG, Abraham JM, Meltzcr SJ: The MTS1 gene is frequently mutated in primary human esophageal tumors, Oncogene 1994; 9:3737-3741.
14. Xiao S, Li D, Corson JM, Vijg J, Fletcher JA: Codeletion of pi 5 and p 16 genes in primary non-small cell lung carcinoma, Cancer Res 1995; 55:2968-2971.
15. Caldas C, Hahn SA, da Costa LT, Rcdston MS, Schuttc M, Seymour AB, Weinstein CL, Hruban RH, Yco CJ: Frequent somatic mutations and homozygous deletions of the p 16 (MTS1) gene in pancreatic adenocarcinoma, Nat Genet 1994.8: 27-32.
16. Cheng JQ, Jhanwar SC, Klein WM, Bell DW, Lee WC, Altomarc DA, Nobori T, Olopadc OI, Buckler AJ, Testa JR: pl6 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma, Cancer Res 1994;54:5547-5551.
17. Otsuki T, Clark HM, Wellmann A, Jaffe ES, Raffcld M: Involvement of CDK2 (pl6INK4A/MTSl) in human leukemia and lymphoma, Cancer Res 1995;55:1436-1440.
18. Ohnishi H, Kawamura M, Ida K, Sheng XM, Hanada R, Nobori T, Yamamori S, Hayashi Y: Homozygous deletions of p 16/MTS 1 gene are frequent but mutations are infrequent in childhood T-cell lymphoblastic leukemia, Blood 1995:86: 1269-1275.
19. Ogawa S, Hangaishi A, Miyawaki S, Hirosawa S, Miura Y, Takcyama K, Kameda N, Ohtake S, Uikc N, Shi-mazaki C, Toyama K, Hirano M, Mizoguchi H, Kobayashi Y, Furusa-wa S, Saito M, Enti N, Yazaki Y, Ueda R, Hirai H: Loss of the cyclin-dependcnt kinase 4-inhibitor (pl6;MTSl) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies, Blood 1995:86:1548- 1556.
20. Sakata K, Tamura G, Maesawa C, Suzuki Y, Tcrashima M, Satoh K, Eda Y, Suzuki A, Sekiyama S, Sato-date R: Loss of heterozygosity on the short arm of chromosome 9 without pi6 gene mutation in gastric carcinomas, Jpn J Cancer Res 1995:86: 333-335.
21. Kakiuchi H, Watanabe M, Ushijima T, Toyota M, lmai K, Weisburger JH, Sugimura T, Nagao M: Specific 5'-GGGA-3' -> 5'-GGA-3' mutation of Ape gene in rate colon tumors induced by 2-amino-l-methyl-6-phenylimidazo[4.5-b] pyridine, Proc Natl Acad Sci USA 1995:92: 910-914.
22. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5' CpG island methylation is associated with transcriptional silencing of the tumor suppressor pl6/CDKN2/MTSl in human cancers, Nat Med 1995; 1: 686-692.
23. Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Bcart RW, Van Tomout JM, Jones PA: Methylation of the 5' CpG island of the pl6/ CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing, Cancer Res 1995;55:4531-4535.
24. Herman JG, Merlo A, Mao L, Lapi-dus RG, Issa J-PJ, Davidson NE, Sidransky D, Baylin SB: Inactivation of the CDKN2/p 16/MTS 1 gene is frequently associated with aberrant DNA methylation in all common human cancers, Cancer Res 1995:55:4525-4530.
25. Itoh F, Hinoda Y, Ohc M, Ohc Y, Ban N, Endo T, lmai K, Yachi A: Decreased expression of DCC mRNA in human colorectal cancers, Int J Cancer 1993;53:260-263.
26. Hussussian CJ, Struewing JP, Goldstein AM, Higgins PAT, Ally DS, Sheahan MD, Clark WH Jr, Tucker MA, Dracopoli NC: Germline pi6 mutations in familial melanoma, Nat Genet 1994;8:15-21.
27. Igaki H, Sasaki H, Tachimori Y, Kato H, Watanabe H, Kimura T, Harada Y, Sugimura T, Tcrada M: Mutation frequency of the pi6/ CDKN2 gene in primary cancers in the upper digestive tract, Cancer Res 1995;55:3421-3423.
28. Orita M, Iwahara H, Kanazawa H, Hatashi K, Sckiya T: Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms, Proc Natl Acad Sci USA 1989:86:2766- 2770.
29. Zhang SY, Klein-Szanto AJP, Sauter ER, Shafarenko M, Mitsunaga S, Nobori T, Carson DA, Ridge JA, Goodrow TL: Higher frequency of alterations in the pl6/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck, Cancer Res 1994;54: 5050-5053.
30. Kai M, Arakawa H, Sugimoto Y, Murata Y, Ogawa M, Nakamura Y: Infrequent somatic mutation of the MTS1 gene in primary' bladder carcinomas, Jpn J Cancer Res 1995:86: 249-251.
31. Cairns P, Mao L, Mcrlo A, Lee D, Schwab D, Eby Y, Tokino K, van dcr Riet P, Blaugrund J, Sidransky D: Rates of pi 6 (MTS1) mutations in primary tumors with 9p loss, Science 1994:265:415-416.
32. Spruck C, Gonzales-Zuleta M, Shi-bata A, Sinioncau A, Lin M, Gonzales F, Tsai Y, Jones P: p 16 gene in uncultured tumors, Nature 1994; 370:183-184.
33. Marx J: A challenge to p 16 genes as a major tumor suppressor, Science 1994;264:1846.