Organelle stress-induced activating transcription factor-3 downregulates low-density lipoprotein receptor expression in Sk-Hep1 human liver cells

Biological Chemistry

Volumn 392, Issue 4, 2011, Pages 377-385

  Lim, Joo Hyun ^a   Lee, Hyo Jung ^a   Pak, Youngmi Kim ^b   Kim, Won Ho ^a   Song, Jihyun ^a  

^a Korea National Institute of Health   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

Endoplasmic reticulum (ER) stress response; Mitochondrial dysfunction; Sterol independent regulation

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; LOW DENSITY LIPOPROTEIN RECEPTOR; SMALL INTERFERING RNA;

ARTICLE; BINDING SITE; CELL ORGANELLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION;

ACTIVATING TRANSCRIPTION FACTOR 3; BASE PAIRING; DOWN-REGULATION; ENDOPLASMIC RETICULUM; HUMANS; HYPERCHOLESTEROLEMIA; LIVER; MITOCHONDRIA; PROMOTER REGIONS, GENETIC; RECEPTORS, LDL;

EID: 79955401818     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2011.030     Document Type: Article

References (33)

1. Amuthan, G., Biswas, G., Ananadatheerthavarada, H.K., Vijayasarathy, C., Shephard, H.M., and Avadhani, N.G. (2002). Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene 21, 7839-7849. (Pubitemid 35398842)
2. Attie, A.D. and Seidah, N.G. (2005). Dual regulation of the LDL receptor - some clarity and new questions. Cell Metab. 1, 290-292. (Pubitemid 43960618)
3. Bailly-Maitre, C., Xu, B., and Reed, J.C. (2005). Endoplasmic reticulum stress: Cell life and death decisions. J. Clin. Invest. 115, 2656-2664. (Pubitemid 41434389)
4. Biswas, G., Adebanjo, O.A., Freedman, B.D., Anandatheerthavarada, H.K., Vijayasarathy, C., Zaidi, M., Kotlikoff, M., and Adadhani, N.G. (1999). Retrograde Ca2q signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: A novel mode of inter-organelle crosstalk. EMBO J. 18, 522-533. (Pubitemid 29057237)
5. Black, A.R., Black, J.D., and Azizhhan-Clifford, J. (2001). Sp1 and Kruppel-like factor family of transcription factors in cell growth regulation and cancer. J. Cell. Physiol. 188, 143-160. (Pubitemid 32622905)
6. Colgan, S.M., Tang, D., Werstuck, G.H., and Austin, R.C. (2007). Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2. Int. J. Biochem. Cell Biol. 39, 1843-1851. (Pubitemid 47321345)
7. Cohen, J., Ertsemilidis, A., Kotowski, I.K., Graham, R., Garcia, C.K., and Hobbs, H.H. (2005). Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat. Genet. 37, 161-165.
8. Duchen, M.R. (2004). Roles of mitochondria in health and disease. Diabetes 53 (Suppl. 1), S96-S102. (Pubitemid 38168700)
9. Goldstein, J.L., DeBose-Boyd, R.A., and Brown, M.S. (2006). Protein sensors for membrane sterols. Cell 124, 35-46.
10. Hai, T., Wolfgang, C.D., Marsee, D.K., Allen, A.E., and Sivaprasad, U. (1999). ATF3 and stress responses. Gene Expr. 7, 321-335. (Pubitemid 29372076)
11. Hartman, M.G., Lu, D., Kim, M.L., Kociba, G.J., Shukri, T., Buteau, J., Wang, X., Frankel, W. L., Guttridge, D., Prentki, M., et al. (2004). Role for activating transcription factor 3 in stressinduced beta-cell apoptosis. Mol. Cell. Biol. 24, 5721-5732. (Pubitemid 38787958)
12. Horton, J.D., Cohen, J.C., and Hobbs, H.H. (2007). Molecular biology of PCSK9: Its role in LDL metabolism. Trends Biochem. Sci. 32, 71-77. (Pubitemid 46199197)
13. Hotamisligil, G.S. (2010). Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140, 900-917.
14. Inoue, K., Kamimoto, T., Aoki, R., Ikeda, Y., Kimura, H., and Hagiwara, M. (2004). TNFa-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells. Genes Cells 9, 59-70. (Pubitemid 38180882)
15. Jeong, J.H., Cho, S., and Pak, Y.K. (2009). Sterol-independent repression of low density lipoprotein receptor promoter by peroxisome proliferator- activated receptor coactivator-1 (PGC-1). Exp. Mol. Med. 41, 406-416.
16. Kammoun, H.L., Chabanon, H., Hainault, I., Luquet, S., Magnan, C., Koike, T., Ferre, P., and Foufelle, F. (2009). GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest. 119, 1201-1215.
17. Koh, E.H., Park, J., Park, H., Jeon, M.J., Ryu, J.W., Kim, M., Kim, S.Y., Kim, M., Kim, S., Park, I.S., et al. (2007). Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes 56, 2973-2981. (Pubitemid 350223632)
18. Kim, H.B., Kong, M., Kim, T.M., Suh, Y.H., Kim, W.H., Lim, J.H., Song, J., and Jung M.H. (2006). NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes. Diabetes 55, 1342-1352. (Pubitemid 44195373)
19. Lu, D., Chen, J., and Hai, T. (2007). The regulation of ATF3 gene expression by mitogen-activated protein kinases. Biochem. J. 401, 559-567. (Pubitemid 46166437)
20. Lim, J.H., Lee, J.I., Suh, Y.H., Kim, W.H., Song, J., and Jung, M.H. (2006). Mitochondrial dysfunction induces aberrant insulin signaling and glucose utilization in murine C2C12 myotube cells. Diabetologia 49, 1924-1936. (Pubitemid 44025048)
21. Lim, J.H., Lee, H.J., Jung, M.H., and Song, J. (2008). Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: A molecular mechanism leading to hepatic insulin resistance. Cell. Signal. 21, 169-177.
22. Lowell, B.B. and Shulman, G.I. (2005). Mitochondrial dysfunction and type 2 diabetes. Science 307, 384-387. (Pubitemid 40139974)
23. Maassen, J.A. (2002). Mitochondrial diabetes: Pathophysiology, clinical presentation, and genetic analysis. Am. J. Med. Genet. 115, 66-70. (Pubitemid 34650725)
24. Mattevi, V.S., Coimbra, C.E.A., Jr., Santos, R.V., Salzano, F.M., and Hutz, M.H. (2000). Association of the low-density lipoprotein receptor gene with obesity in native American populations. Hum. Genet. 106, 546-552. (Pubitemid 30406681)
25. Naoumova, R.P. and Soutar, A.K. (2007). Mechanisms of disease: Genetic causes of familial hypercholesterolemia. Nat. Clin. Pract. Cardiovasc. Med. 4, 214-225. (Pubitemid 46502094)
26. Natesampillai, S., Fernandez-Zapico, F., Urrutia, R., and Veldhuis, J.D. (2006). A novel functional interaction between the sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low-density lipoprotein receptor promoter function. J. Biol. Chem. 281, 3040-3047. (Pubitemid 43845913)
27. Oh, J., Choi, Y.S., Kim, J., Park, J., Kim, S., Park, K., and Pak, Y.K. (2005). Inhibition of low-density lipoprotein receptor expression by long-term exposure to phorbol ester via p38 mitogen-activated protein kinase pathway. J. Cell. Biochem. 96, 786-794. (Pubitemid 41567549)
28. Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N.N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L.H., and Hotamisligil, G.S. (2004). Endoplasmic reticulum stress links obesity, insulin action and type 2 diabetes. Science 306, 457-461. (Pubitemid 39372439)
29. Petersen, K.F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D.L., Dipietro, L., Cline, G.W., and Shulman, G.I. (2003). Mitochondrial dysfunction in the elderly: Possible role in insulin resistance. Science 300, 1140-1142. (Pubitemid 36583097)
30. Petersen, K.F., Dufour, S., Befroy, D., Garcia, R., and Shulman, G.I. (2004). Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 350, 664-671. (Pubitemid 38364625)
31. Rutkowski, D.T. and Kauman, R.J. (2004). A trip to the ER: Coping with stress. Trends Cell Biol. 14, 20-28. (Pubitemid 38076857)
32. Sudhof, T.C., Van Der Westhuyzen, D.R., Goldstein, J.L., Brown, M.S., and Russell, D.W. (1987). Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. J. Biol. Chem. 262, 10773-10779. (Pubitemid 17127048)
33. Xu, C., Bailly-Maitre, B., and Reed, J.C. (2005). Endoplasmic reticulum stress: Cell life and death decisions. J. Clin. Invest. 115, 2656-2664. (Pubitemid 41434389)