Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring α-helix in conformational dynamics of the GTP-bound Ras family small GTPases

Journal of Biological Chemistry

Volumn 286, Issue 17, 2011, Pages 15403-15412

  Matsumoto, Kousuke ^a   Shima, Fumi ^a   Muraoka, Shin ^a,b   Araki, Mitsugu ^a   Hu, Lizhi ^a   Ijiri, Yuichi ^a   Hirai, Rina ^a   Liao, Jingling ^a   Yoshioka, Takashi ^a   Kumasaka, Takashi ^c   Yamamoto, Masaki ^b   Tamura, Atsuo ^a   Kataoka, Tohru ^a  

^a KOBE UNIVERSITY   (Japan)

^b SPring 8 Center ^*  (Japan)

^c JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2-STRUCTURE; CONFORMATIONAL CHANGE; CONFORMATIONAL DYNAMICS; DYNAMIC EQUILIBRIA; GTPASES; GUANOSINES; HYDROGEN BONDING INTERACTIONS; HYDROGEN BONDINGS; MUTATIONAL ANALYSIS; STATE DISTRIBUTIONS; STATE DYNAMICS; STATE TRANSITIONS; STRUCTURAL FEATURE; TRIPHOSPHATE;

CONFORMATIONS; HYDROGEN; QUALITY ASSURANCE;

HYDROGEN BONDS;

GUANOSINE TRIPHOSPHATE; H RAS PROTEIN; M RAS PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; HYDROGEN BOND; MOLECULAR INTERACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; HUMANS; MICE; MOLECULAR DYNAMICS SIMULATION; MONOMERIC GTP-BINDING PROTEINS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS P21(RAS); STRUCTURAL HOMOLOGY, PROTEIN;

EID: 79955366474     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.204933     Document Type: Article

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