Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases

Journal of Biological Chemistry

Volumn 280, Issue 35, 2005, Pages 31267-31275

  Ye, Min ^a   Shima, Fumi ^a   Muraoka, Shin ^b   Liao, Jingling ^a   Okamoto, Hidetsugu ^c   Yamamoto, Masaki ^b,d   Tamura, Atsuo ^c   Yagi, Naoto ^b   Ueki, Tatzuo ^b   Kataoka, Tohru ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^c KOBE UNIVERSITY   (Japan)

^d RIKEN/SPring 8 ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CRYSTAL STRUCTURE; ENZYMES;

BINDING PROPERTIES; CONFORMATIONAL TRANSITION; GTPASES; INTRAMOLECULAR INTERACTIONS;

BIOCHEMISTRY;

GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANYLYLIMIDODIPHOSPHATE; RAF PROTEIN; RAS PROTEIN; THREONINE;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; EFFECTOR CELL; MOLECULAR INTERACTION; NONHUMAN; ONCOGENE RAS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FAMILY; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; GUANYLYL IMIDODIPHOSPHATE; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-RAF; RAP GTP-BINDING PROTEINS; RAS PROTEINS; SEQUENCE ALIGNMENT;

EID: 24744454163     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M505503200     Document Type: Article

References (31)

1. Barbacid, M. (1987) Annu. Rev. Biochem. 56, 779-827
2. Lowy, D. R., and Willumsen, B. M. (1993) Annu. Rev. Biochem. 62, 851-891
3. Vojtek, A. B., and Der, C. J. (1998) J. Biol. Chem. 273, 19925-19928
4. Corbett, K. D., and Alber, T. (2001) Trends Biochem. Sci. 26, 710-716
5. Vetter, I. R., and Wittinghofer, A. (2001) Science 294, 1299-1304
6. Nassar, N., Horn, G., Herrmann, C., Scherer, A., McCormick, F., and Wittinghofer, A. (1995) Nature 375, 554-560
7. Geyer, M., Herrmann, C., Wohlgemuth, S., Wittinghofer, A., and Kalbitzer, H. R. (1997) Nat. Struct. Biol. 4, 694-699
8. Huang, L., Hofer, F., Martin, G. S., and Kim, S. H. (1998) Nat. Struct. Biol. 5, 422-426
9. Pacold, M. E., Suire, S., Perisic, O., Lara-Gonzalez, S., Davis, C. T., Walker, E. H., Hawkins, P. T., Stephens, L., Eccleston, J. F., and Williams, R. L. (2000) Cell 103, 931-943
10. Geyer, M., Schweins, T., Herrmann, C., Prisner, T., Wittinghofer, A., and Kalbitzer, H.R. (1996) Biochemistry 35, 10308-10320
11. Spoerner, M., Herrmann, C., Vetter, I. R., Kalbitzer, H. R., and Wittinghofer, A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 4944-4949
12. Kimmelman, A., Tolkacheva, T., Lorenzi, M. V., Osada, M., and Chan, A. M. (1997) Oncogene 15, 2675-2685
13. Quilliam, L. A., Castro, A. F., Rogers-Graham, K. S., Martin, C. B., Der, C. J., and Bi, C. (1999) J. Biol. Chem. 274, 23850-23857
14. Rodriguez-Viciana, P., Sabatier, C., and McCormick, F. (2004) Mol. Cell. Biol. 24, 4943-4954
15. Rebhun, J. F., Castro, A. F., and Quilliam, L. A. (2000) J. Biol. Chem. 275, 34901-34908
16. Gao, X., Satoh, T., Liao, Y., Song, C., Hu, C. D., Kariya, K., and Kataoka, T. (2001) J. Biol. Chem. 276, 42219-42225
17. Cherfils, J., Menetrey, J., Le Bras, G., Janoueix-Lerosey, I., de Gunzburg, J., Garel, J. R., and Auzat, I. (1997) EMBO J. 16, 5582-5591
18. Leslie, A. G. W. (1992) Joint CCP4 + ESF-EAMCB Newsletter on Protein Crystallography 26, Daresbury, Warrington, UK
19. Collaborative Computational Project 4 (1994) Acta Crystallogr. Sect. D 50, 760-763
20. Navaza, J. (1994) Acta Crystallogr. Sect. A 57, 157-163
21. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D 54, 905-921
22. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta. Crystallogr. Sect. D 53, 240-255
23. McRee, D. E. (1993) Practical Protein Crystallography, Academic Press, Inc., San Diego, CA
24. Bacon, D. J., and Anderson, W. F. (1988) J. Mol. Graphics 6, 219-220
25. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
26. Pai, E. F., Kabsch, W., Krengel, U., Holmes, K. C., John, J., and Wittinghofer, A. (1989) Nature 341, 209-214
27. Pai, E. F., Krengel, U., Petsko, G. A., Goody, R. S., Kabsch, W., and Wittinghofer, A. (1990) EMBO J. 9, 2351-2359
28. Bellew, B. F., Halkides, C. J., Gerfen, G. J., Griffin, R. G., and Singel, D. J. (1996) Biochemistry 35, 12186-12193
29. Halkides, C. J., Bellew, B. F., Gerfen, G. J., Farrar, C. T., Carter, P. H., Ruo, B., Evans, D. A., Griffin, R. G., and Singel, D. J. (1996) Biochemistry 35, 12194-12200
30. Linnemann, T., Geyer, M., Jaitner, B. K., Block, C., Kalbitzer, H. R., Wittinghofer, A., and Herrmann, C. (1999) J. Biol. Chem. 274, 13556-13562
31. Iuga, A., Spoerner, M., Kalbitzer, H. R., and Brunner, E. (2004) J. Mol. Biol. 342, 1033-1040