Characterization of a Ras mutant with identical GDP- and GTP-bound structures

Biochemistry

Volumn 48, Issue 48, 2009, Pages 11449-11457

  Ford, Bradley ^a   Boykevisch, Sean ^b   Zhao, Chen ^b   Kunzelmann, Simone ^c   Bar Sagi, Dafna ^b   Herrmann, Christian ^c   Nassar, Nicolas ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACCESSIBLE SURFACE AREAS; BOUND STRUCTURE; DISSOCIATION RATES; DOMINANT NEGATIVE; DOUBLE MUTANTS; NUCLEOTIDE BINDING MOTIF; NUCLEOTIDE EXCHANGE; OPEN CONFORMATION; OVER-EXPRESSION; STOPPED FLOW EXPERIMENTS; STRUCTURAL INFORMATION; TWO-STEP KINETICS; WILD TYPES;

DISSOCIATION;

NUCLEOTIDES;

GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ANIMALS; CATALYSIS; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; KINETICS; LYSINE; MUTANT PROTEINS; MUTATION; PROTEIN CONFORMATION; RAS PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 73149088635     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901479b     Document Type: Article

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