Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

Nature Structural Biology

Volumn 4, Issue 9, 1997, Pages 694-699

  Geyer, Matthias ^a   Kalbitzer, Hans Robert ^a   Herrmann, Christian ^b   Wohlgemuth, Sabine ^b   Wittinghofer, Alfred ^b  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; RAP PROTEIN; RAS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; LETTER; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; GTP-BINDING PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RAP GTP-BINDING PROTEINS; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 0031228462     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0997-694     Document Type: Article

References (30)

1. Bourne, H.R., Sanders, D.A. & McCormick, F. Nature 349, 117-127 (1991).
2. McCormick, F. & Wittinghofer, A. Curr. Op. Biotechn. 7, 449-456 (1996).
3. Emerson, S.D. et al. Biochemistry 34, 6911-6918 (1995).
4. Nassar, N. et al. Nature 375, 554-560 (1995).
5. Albright, C.F., Giddings, B.W., Liu, J., Vito, M. & Weinberg, R.A. EMBOJ. 12, 339-347 (1993).
6. Spaargaren, M. & Bischoff, J.R. Proc. Natl. Acad. Sci. U.S.A. 91, 12609-12613 (1994).
7. Kikuchi, A., Demo, S.D., Ye, Z.-H., Chen, Y.-W. & Williams, L.T. Mol. Cell. Biol. 14, 7483-7491 (1994).
8. Wolthuis, R.M.F. et al. Oncogene 13, 353-362 (1996).
9. Feig, L.A., Urano, T. & Cantor, S. TIBS 21, 438-441 (1996).
10. Herrmann, C., Horn, G., Spaargaren, M. & Wittinghofer, A. J. Biol. Chem. 271, 6794-6800 (1996).
11. Orengo, C.A., Jones, D.T. & Thornton, J.M. Nature 372, 631-634 (1994).
12. Ponting, C.P. & Benjamin, D.R. TIBS 21, 422-425 (1996).
13. Geyer, M. et al. Biochemistry 35, 10308-10320 (1996).
14. Nassar, N. et al. Nature Struct. Biol. 3, 723-729 (1996).
15. White, M.A., Vale, T., Camonis, J.H., Schaefer, E. & Wigler, M.H, J. Biol. Chem. 271, 16439-16442 (1996).
16. Stokoe, D., MacDonald, S.G., Cadwallader, K., Symons, M. & Hancock, J.F. Science 264, 1463-1467 (1994).
17. Leevers, S.J., Paterson, H.F. & Marshall, C.J. Nature 369, 411-414 (1994).
18. Yamamori, B. et al. J. Biol. Chem. 270, 11723-11726 (1995).
19. Pai, E.F. et al. EMBOJ. 9, 2351-2359 (1990).
20. Yamazaki, T., Lee, W., Arrowsmith C.H., Muhandiram, D.R. & Kay, L.E. J. Am. Chem. Soc. 116, 11655-11666 (1994).
21. Davis, D.G. & Bax, A. J. Am. Chem. Soc. 107, 2820-2821 (1985).
22. Jeener, J., Meier, B.H., Bachmann, P. & Ernst, R.R. J. Chem. Phys. 71, 4546-4553 (1979).
23. Marion, D., Kay, L.E., Sparks, S.W., Torchia, D.A. & Bax, A. J. Am. Chem. Soc. 111, 1515-1517 (1989).
24. Gorier, A. & Kalbitzer, H. R. J. Magn. Res. 124, 177-188 (1997).
25. Neidig, K.-P. et al. J. Bio. NMR 6, 255-270 (1995).
26. Brunger, A.T. X-PLOR, Version 3.1 (Yale University Press, New Haven, Connecticut; 1992).
27. Nilges, M., Clore, G. M. & Gronenborn, A. M. FEBS Lett. 229, 317-324 (1988).
28. Koradi, R., Billeter, M. & Wuthrich, K.J. Mol. Graphics 14, 51-55(1996).
29. Nicholls, A., Sharp, K.A. & Honig, B. Proteins Struct. Func. Genet. 11, 281-296 (1991).
30. Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard, M. Acta Crystallogr. A47, 110-119 (1991).