Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 2, 2011, Pages 400-410

  Thomas, Karen C ^a   Ethirajan, Manivannan ^a,c   Shahrokh, Kiumars ^a   Sun, Hao ^a,d   Lee, Jeewoo ^b   Cheatham III, Thomas E ^a   Yost, Garold S ^a   Reilly, Christopher A ^a  

^a UNIVERSITY OF UTAH   (United States)

^b Seoul National University   (South Korea)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3 HYDROXY 4 METHOXYBENZYL)NONANAMIDE; (3,4 DIHYDROXYBENZYL)NONANAMIDE; 3 METHOXY 4 (NONAMIDOMETHYL)PHENYL SULFATE; ACETYLCYSTEINE; BENZYLNONANAMIDE; CALCIUM ION; CAPSAICIN DERIVATIVE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; N (3 METHOXYBENZYL)NONANAMIDE; N (3,4 DIMETHOXYBENZYL)NONANAMIDE; N (4 HYDROXYBENZYL)NONANAMIDE; N (4 TRIFLUOROMETHYLBENZYL)NONANAMIDE; NONIVAMIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ARTICLE; CALCIUM TRANSPORT; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MOLECULAR MODEL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

CALCIUM; CAPSAICIN; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FLUOROMETRY; HUMANS; LUNG; MODELS, MOLECULAR; RESPIRATORY MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTOR CHOP; TRPV CATION CHANNELS;

EID: 79955036984     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.178491     Document Type: Article

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