Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists

British Journal of Pharmacology

Volumn 139, Issue 8, 2003, Pages 1417-1424

  Appendino, Giovanni ^a   Harrison, Selena ^b   De Petrocellis, Luciano ^c   Daddario, Nives ^a   Bianchi, Federica ^a   Moriello, Aniello Schiano ^c   Trevisani, Marcello ^b   Benvenuti, Francesca ^b   Geppetti, Pierangelo ^b   Di Marzo, Vincenzo ^d  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c CNR   (Italy)

^d CNR   (Italy)

Author keywords

Capsaicin; Halogenated derivatives; Pain; Receptor; Resiniferatoxin; TRPV1; Vanilloid

Indexed keywords

5 BROMONORDIHYDROCAPSAICIN; 5 CHLORONORDIHYDROCAPSAICIN; 5 IODONORDIHYDROCAPSAICIN; 5 IODORESINIFERATOXIN; 6 BROMONORDIHYDROCAPSAICIN; 6 CHLORONORDIHYDROCAPSAICIN; 6 IODONORDIHYDROCAPSAICIN; CAPSAICIN; CAPSAICIN DERIVATIVE; CAPSAZEPINE; IODINE DERIVATIVE; SB 366791; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

ARTICLE; BINDING AFFINITY; BLADDER; BRONCHUS; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EMBRYO; GUINEA PIG; HALOGENATION; HUMAN; HUMAN CELL; IC 50; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL GANGLION; STEREOCHEMISTRY;

ANIMALS; CALCIUM; CAPSAICIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; GUINEA PIGS; HUMANS; HYDROCARBONS, HALOGENATED; KIDNEY; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEURONS; RATS; RECEPTORS, DRUG; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRACHEA; TRANSFECTION; URINARY BLADDER;

EID: 10744226892     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705387     Document Type: Article

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