Stereospecific high-affinity TRPV1 antagonists: Chiral N-(2-benzyl-3- pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues

Journal of Medicinal Chemistry

Volumn 51, Issue 1, 2008, Pages 57-67

  Ryu, Hyungchul ^a   Jin, Mi Kyoung ^a   Su, Yeon Kim ^a   Choi, Hyun Kyung ^a   Kang, Sang Uk ^a   Dong, Wook Kang ^a   Lee, Jeewoo ^a   Pearce, Larry V ^b   Pavlyukovets, Vladimir A ^b   Morgan, Matthew A ^b   Tran, Richard ^b   Toth, Attila ^a,b   Lundberg, Daniel J ^b   Blumberg, Peter M ^b  

^a Seoul National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESYLIC ACID DERIVATIVE; N (2 BENZYL 3 PIVALOYLOXYPROPYL) 2 [4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE DERIVATIVE; N [2 (4 TERT BUTYLBENZYL) 3 (PIVALOYLOXY)PROPYL] 2 [3 CHLORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N [2 (4 TERT BUTYLBENZYL) 3 (PIVALOYLOXY)PROPYL] 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N [2 BENZYL 3 (PIVALOYLOXY)PROPYL] 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; PROPIONAMIDE DERIVATIVE; RECEPTOR BLOCKING AGENT; RESINIFERATOXIN; THIOUREA; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL CELL; ARTICLE; CHIRALITY; CHO CELL; DRUG POTENCY; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; PROCESS OPTIMIZATION; RECEPTOR AFFINITY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZENEACETAMIDES; BINDING SITES; BINDING, COMPETITIVE; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; HYDROPHOBICITY; MESYLATES; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 37849014297     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701049p     Document Type: Article

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