Comparative study of culture conditions for maintaining CYP3A4 and ATP-binding cassette transporters activity in primary cultured human hepatocytes

Journal of Pharmacological Sciences

Volumn 115, Issue 4, 2011, Pages 516-524

  Takeba, Yuko ^a   Matsumoto, Naoki ^a   Takenoshita Nakaya, Sachiko ^a   Harimoto, Yoshie ^a   Kumai, Toshio ^a   Kinoshita, Yuichi ^a   Nakano, Hiroshi ^a   Ohtsubo, Takehito ^a   Kobayashi, Shinichi ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

ATP binding cassette transporter; CYP3A4; HNF 4 ; Lanford's medium; Primary hepatocyte

Indexed keywords

ABC TRANSPORTER; ALBUMIN; BREAST CANCER RESISTANCE PROTEIN; CYTOCHROME P450 2C; CYTOCHROME P450 2C19; CYTOCHROME P450 2D; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXAMETHASONE; GLYCOPROTEIN P; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; RIFAMPICIN;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; CULTURE MEDIUM; CULTURE TECHNIQUE; FETAL CALF SERUM WILLIAM E MEDIUM; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN SERUM WILLIAM E MEDIUM; IN VIVO CULTURE; INTERMETHOD COMPARISON; LIVER CELL CULTURE; PROTEIN EXPRESSION; SERUM FREE WILLIAM E MEDIUM;

EID: 79954994414     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10215FP     Document Type: Article

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