-
1
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C. A., Lombardodominy, B.W. and Feeney, P. J.: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev., 46: 3-26 (2001).
-
(2001)
Adv. Drug Deliv. Rev.
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardodominy, B.W.2
Feeney, P.J.3
-
2
-
-
0034461768
-
Drug-like properties and the cause of poor solubility and poor permeability
-
Lipinski, C. A.: Drug-like properties and the cause of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods., 44: 235-249 (2000).
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.44
, pp. 235-249
-
-
Lipinski, C.A.1
-
3
-
-
0017670555
-
Theoretic aspects of pharmacokinetic drug interactions
-
Gillette, J. R. and Pang, K. S.: Theoretic aspects of pharmacokinetic drug interactions. Clin. Pharmacol. Ther., 22: 623-639 (1977).
-
(1977)
Clin. Pharmacol. Ther.
, vol.22
, pp. 623-639
-
-
Gillette, J.R.1
Pang, K.S.2
-
4
-
-
0030937636
-
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
-
Iwatsubo, T., Hirota, N., Ooie, T., Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C. E., Tyson, C. A. and Sugiyama, Y.: Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data. Pharmacol. Ther., 73: 147-171 (1997).
-
(1997)
Pharmacol. Ther.
, vol.73
, pp. 147-171
-
-
Iwatsubo, T.1
Hirota, N.2
Ooie, T.3
Suzuki, H.4
Shimada, N.5
Chiba, K.6
Ishizaki, T.7
Green, C.E.8
Tyson, C.A.9
Sugiyama, Y.10
-
5
-
-
0031777718
-
Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport
-
Ito, K., Iwatsubo, T., Kanamitsu, S., Nakajima, Y. and Sugiyama, Y.: Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport. Annu. Rev. Pharmacol. Toxicol., 38: 461-499 (1998).
-
(1998)
Annu. Rev. Pharmacol. Toxicol.
, vol.38
, pp. 461-499
-
-
Ito, K.1
Iwatsubo, T.2
Kanamitsu, S.3
Nakajima, Y.4
Sugiyama, Y.5
-
6
-
-
0020772399
-
Uptake of iopanic acid by isolated rat hepatocytes in primary culture. Am
-
Barnhart, J. L., Witt, B. L., Hardison, W. G. and RBerk, R. N.: Uptake of iopanic acid by isolated rat hepatocytes in primary culture. Am. J. Physiol., 244: G630-G636 (1983).
-
(1983)
J. Physiol
, vol.244
, pp. G630-G636
-
-
Barnhart, J.L.1
Witt, B.L.2
Hardison, W.G.3
RBerk, R.N.4
-
7
-
-
0019425855
-
Albumin helps mediate removal of taurocholate by rat liver
-
Forker, E. L. and Luxon, B. A.: Albumin helps mediate removal of taurocholate by rat liver. J. Clin. Invest., 67: 1517-1522 (1981).
-
(1981)
J. Clin. Invest
, vol.67
, pp. 1517-1522
-
-
Forker, E.L.1
Luxon, B.A.2
-
8
-
-
0021905486
-
The role of albumin in the hepatic transport of bililubin: Studies in mutanat analbuminemic rats
-
Inoue, M., Hirata, E., Morino, Y., Nagase, S., Chowdhury, J. R., Chowdhury, N. R. and Arias, I. M.: The role of albumin in the hepatic transport of bililubin: Studies in mutanat analbuminemic rats. J. Biochem. (Tokyo), 97: 737-743 (1985).
-
(1985)
J. Biochem. (Tokyo
, vol.97
, pp. 737-743
-
-
Inoue, M.1
Hirata, E.2
Morino, Y.3
Nagase, S.4
Chowdhury, J.R.5
Chowdhury, N.R.6
Arias, I.M.7
-
9
-
-
0021012347
-
Plasma clearance of BSP and its interaction with hepatic binding protein in normal and analbuminemic rats: Is plasma albumin essential for vectorial transport of organic anions in the liver?
-
USA
-
Inoue, M., Okajima, K., Nagase, S. and Morino, Y.: Plasma clearance of BSP and its interaction with hepatic binding protein in normal and analbuminemic rats: Is plasma albumin essential for vectorial transport of organic anions in the liver? Proc. Natl. Acad. Sci., USA, 80: 7654-7658 (1983).
-
(1983)
Proc. Natl. Acad. Sci.
, vol.80
, pp. 7654-7658
-
-
Inoue, M.1
Okajima, K.2
Nagase, S.3
Morino, Y.4
-
10
-
-
0023877619
-
Protein-mediated hepatic uptake of rose-bengal in analbuminemic mutant rats (NAR): Albumin is not indispensable to the proteinmediated transport of rose-bengal
-
Tsao, S. C., Sugiyama, Y., Shinmura, K., Sawada, Y., Nagase, S., Iga, T. and Hanano, M.: Protein-mediated hepatic uptake of rose-bengal in analbuminemic mutant rats (NAR): Albumin is not indispensable to the proteinmediated transport of rose-bengal. Drug Metab. Dispos., 16: 482-489 (1988).
-
(1988)
Drug Metab. Dispos.
, vol.16
, pp. 482-489
-
-
Tsao, S.C.1
Sugiyama, Y.2
Shinmura, K.3
Sawada, Y.4
Nagase, S.5
Iga, T.6
Hanano, M.7
-
11
-
-
0019450585
-
Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances.
-
Weisiger, R. A., Gollan, J. and Ockner, R.: Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances. Science, 211: 1048-1051 (1981).
-
(1981)
Science
, vol.211
, pp. 1048-1051
-
-
Weisiger, R.A.1
Gollan, J.2
Ockner, R.3
-
12
-
-
18844475922
-
Hepatic transport and binding of rose bengal in the presence of albumin and gamma globulin
-
Forker, E. L., Luxon, B. A. and Sharma, V. S.: Hepatic transport and binding of rose bengal in the presence of albumin and gamma globulin. Am. J. Physiol., 248: G702-G708 (1985).
-
(1985)
Am. J. Physiol.
, vol.248
, pp. G702-G708
-
-
Forker, E.L.1
Luxon, B.A.2
Sharma, V.S.3
-
13
-
-
0022083094
-
Eŝects of unstirred Disse fluid, nonequilibrium binding, surface-mediated dissociation on hepatic removal of albumin-bound organic anions. Am
-
Forker, E. L. and Luxon, B. A.: Eŝects of unstirred Disse fluid, nonequilibrium binding, and surface-mediated dissociation on hepatic removal of albumin-bound organic anions. Am. J. Physiol., 248: G709-G717 (1985).
-
(1985)
J. Physiol
, vol.248
, pp. G709-G717
-
-
Forker, E.L.1
Luxon, B.A.2
-
14
-
-
0026677081
-
Albumin-mediated transport phenomenon observed for ligands with high membrane permeability. Eŝect of the unstirred water layer in the Disse‚s space of rat liver
-
Ichikawa, M., Tsao, S. C., Lin, T.-H., Miyauchi, S., Sawada, Y., Iga, T., Hanano, M. and Sugiyama, Y.: Albumin-mediated transport phenomenon observed for ligands with high membrane permeability. Eŝect of the unstirred water layer in the Disse‚s space of rat liver. J. Hepatology, 16: 38-49 (1992).
-
(1992)
J. Hepatology
, vol.16
, pp. 38-49
-
-
Ichikawa, M.1
Tsao, S.C.2
Lin, T.-H.3
Miyauchi, S.4
Sawada, Y.5
Iga, T.6
Hanano, M.7
Sugiyama, Y.8
-
15
-
-
0023695140
-
Kinetic analysis of albumin-mediated uptake of warfarin by perfused rat liver
-
Tsao, S. C., Sugiyama, Y., Sawada, Y., Iga, T. and Hanano, M.: Kinetic analysis of albumin-mediated uptake of warfarin by perfused rat liver. J. Pharmacokinet. Biopharm., 16: 165-181 (1988).
-
(1988)
J. Pharmacokinet. Biopharm
, vol.16
, pp. 165-181
-
-
Tsao, S.C.1
Sugiyama, Y.2
Sawada, Y.3
Iga, T.4
Hanano, M.5
-
16
-
-
0022636628
-
Characterization of the interaction of albumin with isolated rat liver cells to reveal the mechanism of albuminmediated hepatic transport
-
Mizuma, T., Horie, T., Hayashi, M. and Awazu, S.: Characterization of the interaction of albumin with isolated rat liver cells to reveal the mechanism of albuminmediated hepatic transport. J. Pharmacobio-dyn., 9: 244-248 (1986).
-
(1986)
J. Pharmacobio-dyn
, vol.9
, pp. 244-248
-
-
Mizuma, T.1
Horie, T.2
Hayashi, M.3
Awazu, S.4
-
17
-
-
0030825141
-
Eŝect of albumin on the estimation, in vitro, of phenytoin Vmax and Km values: Implications for clinical correlation
-
Ludden, L. K., Ludden, T. M., Collins, J. M., Pentikins, H. S. and Strong, J. M.: Eŝect of albumin on the estimation, in vitro, of phenytoin Vmax and Km values: Implications for clinical correlation. J. Pharmacol. Exp. Ther., 282: 391-396 (1997).
-
(1997)
J. Pharmacol. Exp. Ther
, vol.282
, pp. 391-396
-
-
Ludden, L.K.1
Ludden, T.M.2
Collins, J.M.3
Pentikins, H.S.4
Strong, J.M.5
-
18
-
-
0032995197
-
Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans. Br
-
Carlile, D. J., Hakooz, N., Bayliss, M. K. and Houston, J. B.: Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans. Br. J. Clin. Pharmacol., 47: 625-635 (1999).
-
(1999)
J. Clin. Pharmacol
, vol.47
, pp. 625-635
-
-
Carlile, D.J.1
Hakooz, N.2
Bayliss, M.K.3
Houston, J.B.4
-
19
-
-
0009211650
-
Phenytoin and tolbutamide metabolism in human liver microsomes: Complex eŝects of albumin on P450 activity
-
Qiu, W., Kunze, K. L., Mather, G. G., Black, C. and Levy, R. H.: Phenytoin and tolbutamide metabolism in human liver microsomes: Complex eŝects of albumin on P450 activity. Drug Metab. Rev., 32: supp. 2, 222 (2000).
-
(2000)
Drug Metab. Rev.
, vol.32
, pp. 222
-
-
Qiu, W.1
Kunze, K.L.2
Mather, G.G.3
Black, C.4
Levy, R.H.5
-
20
-
-
78649983023
-
Protein binding and drug metabolism: Eŝects of human serum albumin on coumarin metabolism in human hepatocytes
-
Li, A. P., Sakai, Y., Lu, C., Fackett, A. and Lin, J.: Protein binding and drug metabolism: Eŝects of human serum albumin on coumarin metabolism in human hepatocytes. Drug Metab. Rev., 32: supp. 2, 242 (2000).
-
(2000)
Drug Metab. Rev.
, vol.32
, pp. 242
-
-
Li, A.P.1
Sakai, Y.2
Lu, C.3
Fackett, A.4
Lin, J.5
-
21
-
-
0035826049
-
Interaction of plasma proteins with cytochromes P450 mediated metabolic reactions: inhibition by human serum albumin and alpha-globulins of the debrisoquine 4-hydroxylation (CYP2D) in liver microsomes of human, hamster and rat
-
Ishii, M., Xu, B. Q., Ding, L. R., Fischer, N. E. and Inaba, T.: Interaction of plasma proteins with cytochromes P450 mediated metabolic reactions: inhibition by human serum albumin and alpha-globulins of the debrisoquine 4-hydroxylation (CYP2D) in liver microsomes of human, hamster and rat. Toxicol. Lett., 119: 219-225 (2001).
-
(2001)
Toxicol. Lett.
, vol.119
, pp. 219-225
-
-
Ishii, M.1
Xu, B.Q.2
Ding, L.R.3
Fischer, N.E.4
Inaba, T.5
-
22
-
-
0031466149
-
Nonspecîc binding to microsomes: Impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, propranolol.
-
Obach, R. S.: Nonspecîc binding to microsomes: Impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. Drug Metab. Dispos., 25: 1359-1369 (1997).
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 1359-1369
-
-
Obach, R.S.1
-
23
-
-
0032733974
-
Prediction of human clearance of twentynine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecîc binding to microsomes
-
Obach, R. S.: Prediction of human clearance of twentynine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecîc binding to microsomes. Drug Metab. Dispos., 27: 1350-1359 (1999).
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 1350-1359
-
-
Obach, R.S.1
-
24
-
-
0023355128
-
Hepatic metabolism of tolbutamide: Characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition
-
Knodell, R. G., Hall, S. D., Wilkinson, G. R. and Guengerich, F. P.: Hepatic metabolism of tolbutamide: Characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition. J. Pharmacol. Exp. Ther., 241: 1112-1119 (1987).
-
(1987)
J. Pharmacol. Exp. Ther
, vol.241
, pp. 1112-1119
-
-
Knodell, R.G.1
Hall, S.D.2
Wilkinson, G.R.3
Guengerich, F.P.4
-
25
-
-
0031757521
-
Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flubiprofen, and diclofenac by human liver microsomes
-
Yamazaki, H., Inoue, K., Chiba, K., Ozawa, N., Kawai, T., Suzuki, Y., Goldstein, J. A., Guengerich, F. P. and Shimada, T.: Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flubiprofen, and diclofenac by human liver microsomes. Biochem. Pharmacol., 56: 243-251 (1998).
-
(1998)
Biochem. Pharmacol.
, vol.56
, pp. 243-251
-
-
Yamazaki, H.1
Inoue, K.2
Chiba, K.3
Ozawa, N.4
Kawai, T.5
Suzuki, Y.6
Goldstein, J.A.7
Guengerich, F.P.8
Shimada, T.9
-
26
-
-
0027168405
-
Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation
-
Yun, C.-H., Okerholm, R. A., and Guengerich, F. P.: Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation. Drug Metab. Dispos., 21: 403-409 (1993).
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 403-409
-
-
Yun, C.-H.1
Okerholm, R.A.2
Guengerich, F.P.3
-
27
-
-
0024561369
-
The glutathione S-transferases: An update
-
Boyer, T. D.: The glutathione S-transferases: An update. Hepatology, 9: 486-496 (1989).
-
(1989)
Hepatology
, vol.9
, pp. 486-496
-
-
Boyer, T.D.1
-
28
-
-
0343526160
-
High rates of substrate hydroxylation by human cytochrome P450 3A4 in reconstituted membranous vesicles: influence of membrane charge
-
Ingelman-Sundberg, M., Hagbjork, A. L., Ueng, Y. F., Yamazaki, H. and Guengerich, F. P.: High rates of substrate hydroxylation by human cytochrome P450 3A4 in reconstituted membranous vesicles: influence of membrane charge. Biochem. Biophys. Res. Commun., 221: 318-322 (1996).
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.221
, pp. 318-322
-
-
Ingelman-Sundberg, M.1
Hagbjork, A.L.2
Ueng, Y.F.3
Yamazaki, H.4
Guengerich, F.P.5
-
29
-
-
0029926494
-
Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4: Characterization of a reconstituted cytochrome P450 3A4WNADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5
-
Yamazaki, H., Johnson, W. W., Ueng, Y. F., Shimada, T. and Guengerich, F. P.: Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4: Characterization of a reconstituted cytochrome P450 3A4WNADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5. J. Biol. Chem., 271: 27438-27444 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 27438-27444
-
-
Yamazaki, H.1
Johnson, W.W.2
Ueng, Y.F.3
Shimada, T.4
Guengerich, F.P.5
-
30
-
-
0037080320
-
Determination of drug-plasma protein binding kinetics and equilibria by choromatographic prôling: exemplîcation of the method using L-tryptophan and albumin
-
Talbert, A.M., Tranter, G. E., Holmes, E. and Francis, P. L.: Determination of drug-plasma protein binding kinetics and equilibria by choromatographic prôling: exemplîcation of the method using L-tryptophan and albumin. Anal. Chem., 74: 445-452 (2002).
-
(2002)
Anal. Chem.
, vol.74
, pp. 445-452
-
-
Talbert, A.M.1
Tranter, G.E.2
Holmes, E.3
Francis, P.L.4
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