Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: Treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death

Neuropharmacology

Volumn 60, Issue 7-8, 2011, Pages 1116-1125

  Järvelä, Juha T ^a   Ruohonen, Saku ^a   Kukko Lukjanov, Tiina Kaisa ^a   Plysjuk, Anna ^a   Lopez Picon, Francisco R ^a,b   Holopainen, Irma E ^a,c  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU PET CENTRE   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Developing brain; Excitotoxicity; Hippocampus; Inflammation; Neuroprotection

Indexed keywords

BIOLOGICAL MARKER; GLIAL FIBRILLARY ACIDIC PROTEIN; IBA1 PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; KAINIC ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYCLOOXYGENASE 2; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN IBA1;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONCENTRATION RESPONSE; EXCITOTOXICITY; HIPPOCAMPUS; INFLAMMATION; MICROGLIA; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; BRAIN SLICE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG TREATMENT FAILURE; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPAL CA3 REGION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MEDIATOR RELEASE; NERVE CELL LESION; NEWBORN; OUTCOME ASSESSMENT; REAL TIME POLYMERASE CHAIN REACTION; TISSUE CULTURE; WESTERN BLOTTING;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DEATH; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; INFLAMMATION; KAINIC ACID; MALE; NERVE DEGENERATION; NEURONS; NITROBENZENES; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES;

EID: 79954580535     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.09.024     Document Type: Article

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