메뉴 건너뛰기




Volumn 231, Issue 1, 2011, Pages 76-89

Bistable responses in bacterial genetic networks: Designs and dynamical consequences

Author keywords

Bistability; Design principles; Dynamics; Phenotypic heterogeneity

Indexed keywords

BI-STABILITY; BIOCHEMICAL NETWORK; BIOCHEMICAL RESPONSE; BISTABLES; DESIGN PRINCIPLES; EVOLUTIONARY DESIGN; GENETIC CIRCUITS; GENETIC NETWORKS; INPUT SIGNAL; LIVING CELL; MULTI-STEP; NETWORK DESIGN; PHENOTYPIC HETEROGENEITY; STABLE STEADY STATE; TWO COMPONENT SYSTEMS;

EID: 79954579296     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mbs.2011.03.004     Document Type: Article
Times cited : (57)

References (147)
  • 1
    • 0001389945 scopus 로고
    • Enzyme induction as an all-or-none phenomenon
    • Novick A., Weiner M. Enzyme induction as an all-or-none phenomenon. Proc. Natl. Acad. Sci. USA 1957, 43:553.
    • (1957) Proc. Natl. Acad. Sci. USA , vol.43 , pp. 553
    • Novick, A.1    Weiner, M.2
  • 2
    • 54249083606 scopus 로고    scopus 로고
    • A stochastic single-molecule event triggers phenotype switching of a bacterial cell
    • Choi P.J., Cai L., Frieda K., Xie X.S. A stochastic single-molecule event triggers phenotype switching of a bacterial cell. Science 2008, 322:442.
    • (2008) Science , vol.322 , pp. 442
    • Choi, P.J.1    Cai, L.2    Frieda, K.3    Xie, X.S.4
  • 4
    • 15544388848 scopus 로고    scopus 로고
    • Noise propagation in gene networks
    • Pedraza J.M., van Oudenaarden A. Noise propagation in gene networks. Science 2005, 307:1965.
    • (2005) Science , vol.307 , pp. 1965
    • Pedraza, J.M.1    van Oudenaarden, A.2
  • 6
    • 73049167504 scopus 로고
    • Teleonomic mechanisms in cellular metabolism, growth, and differentiation
    • Monod J., Jacob F. Teleonomic mechanisms in cellular metabolism, growth, and differentiation. Cold Spring Harb. Symp. Quant. Biol. 1961, 26:389.
    • (1961) Cold Spring Harb. Symp. Quant. Biol. , vol.26 , pp. 389
    • Monod, J.1    Jacob, F.2
  • 7
    • 0031879114 scopus 로고    scopus 로고
    • Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected Escherichia coli cells
    • Arkin A., Ross J., McAdams H.H. Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected Escherichia coli cells. Genetics 1998, 149:1633.
    • (1998) Genetics , vol.149 , pp. 1633
    • Arkin, A.1    Ross, J.2    McAdams, H.H.3
  • 10
    • 0032496358 scopus 로고    scopus 로고
    • The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
    • Ferrell J.E., Machleder E.M. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 1998, 280:895.
    • (1998) Science , vol.280 , pp. 895
    • Ferrell, J.E.1    Machleder, E.M.2
  • 11
    • 0345359924 scopus 로고    scopus 로고
    • A positive-feedback-based bistable 'memory module' that governs a cell fate decision
    • Xiong W., Ferrell J.E. A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature 2003, 426:460.
    • (2003) Nature , vol.426 , pp. 460
    • Xiong, W.1    Ferrell, J.E.2
  • 12
    • 0027716813 scopus 로고
    • Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos
    • Novak B., Tyson J.J. Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos. J. Cell Sci. 1993, 106(Pt 4):1153.
    • (1993) J. Cell Sci. , vol.106 , Issue.PART 4 , pp. 1153
    • Novak, B.1    Tyson, J.J.2
  • 14
  • 15
    • 0037452576 scopus 로고    scopus 로고
    • Regulatory gene networks and the properties of the developmental process
    • Davidson E.H., McClay D.R., Hood L. Regulatory gene networks and the properties of the developmental process. Proc. Natl. Acad. Sci. USA 2003, 100:1475.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1475
    • Davidson, E.H.1    McClay, D.R.2    Hood, L.3
  • 18
    • 77955502318 scopus 로고    scopus 로고
    • Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate
    • Narula J., Smith A.M., Gottgens B., Igoshin O.A. Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate. PLoS Comput. Biol. 2010, 6:e1000771.
    • (2010) PLoS Comput. Biol. , vol.6
    • Narula, J.1    Smith, A.M.2    Gottgens, B.3    Igoshin, O.A.4
  • 19
    • 78650362376 scopus 로고    scopus 로고
    • Emerging properties of animal gene regulatory networks
    • Davidson E.H. Emerging properties of animal gene regulatory networks. Nature 2010, 468:911.
    • (2010) Nature , vol.468 , pp. 911
    • Davidson, E.H.1
  • 20
    • 0038241770 scopus 로고    scopus 로고
    • Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli
    • Atkinson M.R., Savageau M.A., Myers J.T., Ninfa A.J. Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Cell 2003, 113:597.
    • (2003) Cell , vol.113 , pp. 597
    • Atkinson, M.R.1    Savageau, M.A.2    Myers, J.T.3    Ninfa, A.J.4
  • 21
    • 17144456808 scopus 로고    scopus 로고
    • Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion
    • Becskei A., Seraphin B., Serrano L. Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. Embo. J. 2001, 20:2528.
    • (2001) Embo. J. , vol.20 , pp. 2528
    • Becskei, A.1    Seraphin, B.2    Serrano, L.3
  • 22
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner T.S., Cantor C.R., Collins J.J. Construction of a genetic toggle switch in Escherichia coli. Nature 2000, 403:339.
    • (2000) Nature , vol.403 , pp. 339
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 25
    • 0001424903 scopus 로고
    • An amplified sensitivity arising from covalent modification in biological systems
    • Goldbeter A., Koshland D.E. An amplified sensitivity arising from covalent modification in biological systems. Proc. Natl. Acad. Sci. USA 1981, 78:6840.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 6840
    • Goldbeter, A.1    Koshland, D.E.2
  • 26
    • 0021715523 scopus 로고
    • Ultrasensitivity in biochemical systems controlled by covalent modification. Interplay between zero-order and multistep effects
    • Goldbeter A., Koshland D.E. Ultrasensitivity in biochemical systems controlled by covalent modification. Interplay between zero-order and multistep effects. J. Biol. Chem. 1984, 259:14441.
    • (1984) J. Biol. Chem. , vol.259 , pp. 14441
    • Goldbeter, A.1    Koshland, D.E.2
  • 27
    • 0023573908 scopus 로고
    • Experimental evidence for a zero-order ultrasensitivity in a simple substrate cycle
    • Cimino A., Hervagault J.F. Experimental evidence for a zero-order ultrasensitivity in a simple substrate cycle. Biochem. Biophys. Res. Commun. 1987, 149:615.
    • (1987) Biochem. Biophys. Res. Commun. , vol.149 , pp. 615
    • Cimino, A.1    Hervagault, J.F.2
  • 28
    • 67149138163 scopus 로고    scopus 로고
    • Protein sequestration generates a flexible ultrasensitive response in a genetic network
    • Buchler N.E., Cross F.R. Protein sequestration generates a flexible ultrasensitive response in a genetic network. Mol. Syst. Biol. 2009, 5:272.
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 272
    • Buchler, N.E.1    Cross, F.R.2
  • 29
    • 0030445778 scopus 로고    scopus 로고
    • Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs
    • Ferrell J.E. Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem. Sci. 1996, 21:460.
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 460
    • Ferrell, J.E.1
  • 30
    • 34548668642 scopus 로고    scopus 로고
    • Quantitative characteristics of gene regulation by small RNA
    • Levine E., Zhang Z., Kuhlman T., Hwa T. Quantitative characteristics of gene regulation by small RNA. PLoS Biol. 2007, 5:e229.
    • (2007) PLoS Biol. , vol.5
    • Levine, E.1    Zhang, Z.2    Kuhlman, T.3    Hwa, T.4
  • 31
    • 56949098506 scopus 로고    scopus 로고
    • Molecular titration and ultrasensitivity in regulatory networks
    • Buchler N.E., Louis M. Molecular titration and ultrasensitivity in regulatory networks. J. Mol. Biol. 2008, 384:1106.
    • (2008) J. Mol. Biol. , vol.384 , pp. 1106
    • Buchler, N.E.1    Louis, M.2
  • 32
    • 72249097352 scopus 로고    scopus 로고
    • Growth rate-dependent global effects on gene expression in bacteria
    • Klumpp S., Zhang Z., Hwa T. Growth rate-dependent global effects on gene expression in bacteria. Cell 2009, 139:1366.
    • (2009) Cell , vol.139 , pp. 1366
    • Klumpp, S.1    Zhang, Z.2    Hwa, T.3
  • 34
    • 33744744785 scopus 로고    scopus 로고
    • Understanding bistability in complex enzyme-driven reaction networks
    • Craciun G., Tang Y., Feinberg M. Understanding bistability in complex enzyme-driven reaction networks. Proc. Natl. Acad. Sci. USA 2006, 103:8697.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8697
    • Craciun, G.1    Tang, Y.2    Feinberg, M.3
  • 35
    • 0023842283 scopus 로고
    • Chemical-reaction network structure and the stability of complex isothermal reactors. 2. Multiple steady-states for networks of deficiency one
    • Feinberg M. Chemical-reaction network structure and the stability of complex isothermal reactors. 2. Multiple steady-states for networks of deficiency one. Chem. Eng. Sci. 1988, 43:1.
    • (1988) Chem. Eng. Sci. , vol.43 , pp. 1
    • Feinberg, M.1
  • 36
    • 79954584915 scopus 로고    scopus 로고
    • ebrary Inc., Enzyme Kinetics and Mechanisms, Kluwer Academic Pub., Dordrecht, Boston.
    • K.B. Taylor, ebrary Inc., Enzyme Kinetics and Mechanisms, Kluwer Academic Pub., Dordrecht, Boston, 2002.
    • (2002)
    • Taylor, K.B.1
  • 37
    • 70349662307 scopus 로고    scopus 로고
    • Dynamic disorder-driven substrate inhibition and bistability in a simple enzymatic reaction
    • Chaudhury S., Igoshin O.A. Dynamic disorder-driven substrate inhibition and bistability in a simple enzymatic reaction. J. Phys. Chem. B 2009, 113:13421.
    • (2009) J. Phys. Chem. B , vol.113 , pp. 13421
    • Chaudhury, S.1    Igoshin, O.A.2
  • 38
    • 44449112421 scopus 로고    scopus 로고
    • Specificity in two-component signal transduction pathways
    • Laub M., Goulian M. Specificity in two-component signal transduction pathways. Ann. Rev. Gen. 2007, 41:121.
    • (2007) Ann. Rev. Gen. , vol.41 , pp. 121
    • Laub, M.1    Goulian, M.2
  • 39
    • 12544258487 scopus 로고    scopus 로고
    • Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli
    • Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A. Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli. J. Biol. Chem. 2005, 280:1448.
    • (2005) J. Biol. Chem. , vol.280 , pp. 1448
    • Yamamoto, K.1    Hirao, K.2    Oshima, T.3    Aiba, H.4    Utsumi, R.5    Ishihama, A.6
  • 45
    • 33747658416 scopus 로고    scopus 로고
    • AI-1 influences the kinase activity but not the phosphatase activity of LuxN of Vibrio harveyi
    • Timmen M., Bassler B.L., Jung K. AI-1 influences the kinase activity but not the phosphatase activity of LuxN of Vibrio harveyi. J. Biol. Chem. 2006, 281:24398.
    • (2006) J. Biol. Chem. , vol.281 , pp. 24398
    • Timmen, M.1    Bassler, B.L.2    Jung, K.3
  • 46
    • 0027202361 scopus 로고
    • Ligand binding to the receptor domain regulates the ratio of kinase to phosphatase activities of the signaling domain of the hybrid Escherichia coli transmembrane receptor, Taz1
    • Jin T., Inouye M. Ligand binding to the receptor domain regulates the ratio of kinase to phosphatase activities of the signaling domain of the hybrid Escherichia coli transmembrane receptor, Taz1. J. Mol. Biol. 1993, 232:484.
    • (1993) J. Mol. Biol. , vol.232 , pp. 484
    • Jin, T.1    Inouye, M.2
  • 47
    • 0037320909 scopus 로고    scopus 로고
    • Instability of sensory histidine kinase mRNAs in Escherichia coli
    • Aiso T., Ohki R. Instability of sensory histidine kinase mRNAs in Escherichia coli. Gene Cell 2003, 8:179.
    • (2003) Gene Cell , vol.8 , pp. 179
    • Aiso, T.1    Ohki, R.2
  • 48
    • 0029116605 scopus 로고
    • Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon
    • Soncini F.C., Véscovi E.G., Groisman E.A. Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon. J. Bacteriol. 1995, 177:4364.
    • (1995) J. Bacteriol. , vol.177 , pp. 4364
    • Soncini, F.C.1    Véscovi, E.G.2    Groisman, E.A.3
  • 50
    • 33645050677 scopus 로고    scopus 로고
    • The vancomycin resistance VanRS two-component signal transduction system of Streptomyces coelicolor
    • Hutchings M., Hong H.-J., Buttner M. The vancomycin resistance VanRS two-component signal transduction system of Streptomyces coelicolor. Mol. Microbiol. 2006, 59:923.
    • (2006) Mol. Microbiol. , vol.59 , pp. 923
    • Hutchings, M.1    Hong, H.-J.2    Buttner, M.3
  • 51
    • 0032851357 scopus 로고    scopus 로고
    • The Cpx envelope stress response is controlled by amplification and feedback inhibition
    • Raivio T.L., Popkin D.L., Silhavy T.J. The Cpx envelope stress response is controlled by amplification and feedback inhibition. J. Bacteriol. 1999, 181:5263.
    • (1999) J. Bacteriol. , vol.181 , pp. 5263
    • Raivio, T.L.1    Popkin, D.L.2    Silhavy, T.J.3
  • 52
    • 33746462208 scopus 로고    scopus 로고
    • Characterization of copper-inducible promoters regulated by CpxA/CpxR in Escherichia coli
    • Yamamoto K., Ishihama A. Characterization of copper-inducible promoters regulated by CpxA/CpxR in Escherichia coli. Biosci. Biotechnol. Biochem. 2006, 70:1688.
    • (2006) Biosci. Biotechnol. Biochem. , vol.70 , pp. 1688
    • Yamamoto, K.1    Ishihama, A.2
  • 54
    • 25144472151 scopus 로고    scopus 로고
    • Unwounded plants elicit Agrobacterium vir gene induction and T-DNA transfer: transformed plant cells produce opines yet are tumour free
    • Brencic A., Angert E., Winans S. Unwounded plants elicit Agrobacterium vir gene induction and T-DNA transfer: transformed plant cells produce opines yet are tumour free. Mol. Microbiol. 2005, 57:1522.
    • (2005) Mol. Microbiol. , vol.57 , pp. 1522
    • Brencic, A.1    Angert, E.2    Winans, S.3
  • 55
    • 33646035209 scopus 로고    scopus 로고
    • A simple system for converting lacZ to gfp reporter fusions in diverse bacteria
    • Goulian M., van der Woude M. A simple system for converting lacZ to gfp reporter fusions in diverse bacteria. Gene 2006, 372:219.
    • (2006) Gene , vol.372 , pp. 219
    • Goulian, M.1    van der Woude, M.2
  • 56
    • 78349256632 scopus 로고    scopus 로고
    • The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response
    • Tiwari A., Balazsi G., Gennaro M.L., Igoshin O.A. The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response. Phys. Biol. 2010, 7:036005.
    • (2010) Phys. Biol. , vol.7 , pp. 036005
    • Tiwari, A.1    Balazsi, G.2    Gennaro, M.L.3    Igoshin, O.A.4
  • 57
    • 77649220067 scopus 로고    scopus 로고
    • Adaptable functionality of transcriptional feedback in bacterial two-component systems
    • Ray J.C.J., Igoshin O. Adaptable functionality of transcriptional feedback in bacterial two-component systems. PLoS Comput. Biol. 2010, 6:e1000676.
    • (2010) PLoS Comput. Biol. , vol.6
    • Ray, J.C.J.1    Igoshin, O.2
  • 58
    • 0037457896 scopus 로고    scopus 로고
    • Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system
    • Batchelor E., Goulian M. Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system. Proc. Natl. Acad. Sci. 2003, 100:691.
    • (2003) Proc. Natl. Acad. Sci. , vol.100 , pp. 691
    • Batchelor, E.1    Goulian, M.2
  • 60
    • 48149084612 scopus 로고    scopus 로고
    • Involvement of nitrogen regulation in Bacillus subtilis degU expression
    • Yasumura A., Abe S., Tanaka T. Involvement of nitrogen regulation in Bacillus subtilis degU expression. J. Bacteriol. 2008, 190:5162.
    • (2008) J. Bacteriol. , vol.190 , pp. 5162
    • Yasumura, A.1    Abe, S.2    Tanaka, T.3
  • 61
    • 0033135671 scopus 로고    scopus 로고
    • When the going gets tough: survival strategies and environmental signaling networks in Bacillus subtilis
    • Msadek T. When the going gets tough: survival strategies and environmental signaling networks in Bacillus subtilis. Trend Microbiol. 1999, 7:201.
    • (1999) Trend Microbiol. , vol.7 , pp. 201
    • Msadek, T.1
  • 62
    • 0035883922 scopus 로고    scopus 로고
    • DNA microarray analysis of Bacillus subtilis DegU, ComA and PhoP regulons: an approach to comprehensive analysis of B. subtilis two-component regulatory systems
    • Ogura M., Yamaguchi H., Yoshida K.-I., Fujita Y., Tanaka T. DNA microarray analysis of Bacillus subtilis DegU, ComA and PhoP regulons: an approach to comprehensive analysis of B. subtilis two-component regulatory systems. Nucleic Acids Res. 2001, 29:3804.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 3804
    • Ogura, M.1    Yamaguchi, H.2    Yoshida, K.-I.3    Fujita, Y.4    Tanaka, T.5
  • 63
    • 0036456146 scopus 로고    scopus 로고
    • Bacillus subtilis functional genomics: genome-wide analysis of the DegS-DegU regulon by transcriptomics and proteomics
    • Mäder, Antelmann, Buder, Dahl, Hecker, Homuth Bacillus subtilis functional genomics: genome-wide analysis of the DegS-DegU regulon by transcriptomics and proteomics. Mol. Gen. Genom. 2002, 268:455.
    • (2002) Mol. Gen. Genom. , vol.268 , pp. 455
    • Mäder1    Antelmann2    Buder3    Dahl4    Hecker5    Homuth6
  • 64
    • 14544290034 scopus 로고    scopus 로고
    • High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis
    • Fujita M., Gonzalez-Pastor J., Losick R. High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis. J. Bacteriol. 2005, 187:1357.
    • (2005) J. Bacteriol. , vol.187 , pp. 1357
    • Fujita, M.1    Gonzalez-Pastor, J.2    Losick, R.3
  • 66
    • 43449134999 scopus 로고    scopus 로고
    • Hysteretic and graded responses in bacterial two-component signal transduction
    • Igoshin O.A., Alves R., Savageau M. Hysteretic and graded responses in bacterial two-component signal transduction. Mol. Microbiol. 2008, 68:1196.
    • (2008) Mol. Microbiol. , vol.68 , pp. 1196
    • Igoshin, O.A.1    Alves, R.2    Savageau, M.3
  • 67
    • 0037192777 scopus 로고    scopus 로고
    • Phosphorylation alters the interaction of the response regulator OmpR with its sensor kinase EnvZ
    • Mattison K., Kenney L.J. Phosphorylation alters the interaction of the response regulator OmpR with its sensor kinase EnvZ. J. Biol. Chem. 2002, 277:11143.
    • (2002) J. Biol. Chem. , vol.277 , pp. 11143
    • Mattison, K.1    Kenney, L.J.2
  • 68
    • 0036886272 scopus 로고    scopus 로고
    • Interaction of EnvZ, a sensory histidine kinase, with phosphorylated OmpR, the cognate response regulator
    • Yoshida T., Cai S., Inouye M. Interaction of EnvZ, a sensory histidine kinase, with phosphorylated OmpR, the cognate response regulator. Mol. Microbiol. 2002, 46:1283.
    • (2002) Mol. Microbiol. , vol.46 , pp. 1283
    • Yoshida, T.1    Cai, S.2    Inouye, M.3
  • 69
    • 33745197543 scopus 로고    scopus 로고
    • Signalling network with a bistable hysteretic switch controls developmental activation of the sigma transcription factor in Bacillus subtilis
    • Igoshin O.A., Price C.W., Savageau M.A. Signalling network with a bistable hysteretic switch controls developmental activation of the sigma transcription factor in Bacillus subtilis. Mol. Microbiol. 2006, 61:165.
    • (2006) Mol. Microbiol. , vol.61 , pp. 165
    • Igoshin, O.A.1    Price, C.W.2    Savageau, M.A.3
  • 70
    • 0031821820 scopus 로고    scopus 로고
    • Feedback loops involving Spo0A and AbrB in in vitro transcription of the genes involved in the initiation of sporulation in Bacillus subtilis
    • Fujita M., Sadaie Y. Feedback loops involving Spo0A and AbrB in in vitro transcription of the genes involved in the initiation of sporulation in Bacillus subtilis. J. Biochem. 1998, 124:98.
    • (1998) J. Biochem. , vol.124 , pp. 98
    • Fujita, M.1    Sadaie, Y.2
  • 72
    • 79954619332 scopus 로고    scopus 로고
    • Society for General Microbiology, in: D.A. Hodgson, C.M. Thomas, Society for General Microbiology (Eds.), Symposium (61st: 2002: Warwick University), Signals, Switches, Regulons, and Cascades: Control of Bacterial Gene Expression, Cambridge University Press, Cambridge, UK, New York, NY.
    • Society for General Microbiology, in: D.A. Hodgson, C.M. Thomas, Society for General Microbiology (Eds.), Symposium (61st: 2002: Warwick University), Signals, Switches, Regulons, and Cascades: Control of Bacterial Gene Expression, Cambridge University Press, Cambridge, UK, New York, NY, 2002.
    • (2002)
  • 73
    • 0028919060 scopus 로고
    • The sigma factors of Bacillus subtilis
    • Haldenwang W.G. The sigma factors of Bacillus subtilis. Microbiol. Rev. 1995, 59:1.
    • (1995) Microbiol. Rev. , vol.59 , pp. 1
    • Haldenwang, W.G.1
  • 74
    • 0039820099 scopus 로고    scopus 로고
    • Eubacterial sigma-factors
    • Wosten M.M. Eubacterial sigma-factors. FEMS Microbiol. Rev. 1998, 22:127.
    • (1998) FEMS Microbiol. Rev. , vol.22 , pp. 127
    • Wosten, M.M.1
  • 76
    • 0025144155 scopus 로고
    • Similar organization of the sigB and spoIIA operons encoding alternate sigma factors of Bacillus subtilis RNA polymerase
    • Kalman S., Duncan M.L., Thomas S.M., Price C.W. Similar organization of the sigB and spoIIA operons encoding alternate sigma factors of Bacillus subtilis RNA polymerase. J. Bacteriol. 1990, 172:5575.
    • (1990) J. Bacteriol. , vol.172 , pp. 5575
    • Kalman, S.1    Duncan, M.L.2    Thomas, S.M.3    Price, C.W.4
  • 77
    • 0029818827 scopus 로고    scopus 로고
    • Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase: molecular cloning and DNA sequencing
    • Wu S., de Lencastre H., Tomasz A. Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase: molecular cloning and DNA sequencing. J. Bacteriol. 1996, 178:6036.
    • (1996) J. Bacteriol. , vol.178 , pp. 6036
    • Wu, S.1    de Lencastre, H.2    Tomasz, A.3
  • 78
    • 0342626726 scopus 로고    scopus 로고
    • Identification and transcriptional characterization of the gene encoding the stress-response sigma factor sigma(H) in streptomyces coelicolor A3(2)
    • Kormanec J., Sevcikova B., Halgasova N., Knirschova R., Rezuchova B. Identification and transcriptional characterization of the gene encoding the stress-response sigma factor sigma(H) in streptomyces coelicolor A3(2). FEMS Microbiol. Lett. 2000, 189:31.
    • (2000) FEMS Microbiol. Lett. , vol.189 , pp. 31
    • Kormanec, J.1    Sevcikova, B.2    Halgasova, N.3    Knirschova, R.4    Rezuchova, B.5
  • 80
    • 34248683237 scopus 로고    scopus 로고
    • Distinctive topologies of partner-switching signaling networks correlate with their physiological roles
    • Igoshin O.A., Brody M.S., Price C.W., Savageau M.A. Distinctive topologies of partner-switching signaling networks correlate with their physiological roles. J. Mol. Biol. 2007, 369:1333.
    • (2007) J. Mol. Biol. , vol.369 , pp. 1333
    • Igoshin, O.A.1    Brody, M.S.2    Price, C.W.3    Savageau, M.A.4
  • 81
    • 2942616403 scopus 로고    scopus 로고
    • Compartmentalization of gene expression during Bacillus subtilis spore formation
    • Hilbert D.W., Piggot P.J. Compartmentalization of gene expression during Bacillus subtilis spore formation. Microbiol. Mol. Biol. Rev. 2004, 68:234.
    • (2004) Microbiol. Mol. Biol. Rev. , vol.68 , pp. 234
    • Hilbert, D.W.1    Piggot, P.J.2
  • 82
    • 0028213705 scopus 로고
    • An adenosine nucleotide switch controlling the activity of a cell type-specific transcription factor in B. subtilis
    • Alper S., Duncan L., Losick R. An adenosine nucleotide switch controlling the activity of a cell type-specific transcription factor in B. subtilis. Cell 1994, 77:195.
    • (1994) Cell , vol.77 , pp. 195
    • Alper, S.1    Duncan, L.2    Losick, R.3
  • 83
    • 17644426967 scopus 로고    scopus 로고
    • Differential gene expression in genetically identical sister cells: the initiation of sporulation in Bacillus subtilis
    • Yudkin M.D., Clarkson J. Differential gene expression in genetically identical sister cells: the initiation of sporulation in Bacillus subtilis. Mol. Microbiol. 2005, 56:578.
    • (2005) Mol. Microbiol. , vol.56 , pp. 578
    • Yudkin, M.D.1    Clarkson, J.2
  • 84
    • 4444312872 scopus 로고    scopus 로고
    • Efficient regulation of sigmaF, the first sporulation-specific sigma factor in B. subtilis
    • Clarkson J., Campbell I.D., Yudkin M.D. Efficient regulation of sigmaF, the first sporulation-specific sigma factor in B. subtilis. J. Mol. Biol. 2004, 342:1187.
    • (2004) J. Mol. Biol. , vol.342 , pp. 1187
    • Clarkson, J.1    Campbell, I.D.2    Yudkin, M.D.3
  • 85
    • 0033054358 scopus 로고    scopus 로고
    • The SpoIIE phosphatase, the sporulation septum and the establishment of forespore-specific transcription in Bacillus subtilis: a reassessment
    • Arigoni F., Guerout-Fleury A.M., Barak I., Stragier P. The SpoIIE phosphatase, the sporulation septum and the establishment of forespore-specific transcription in Bacillus subtilis: a reassessment. Mol. Microbiol. 1999, 31:1407.
    • (1999) Mol. Microbiol. , vol.31 , pp. 1407
    • Arigoni, F.1    Guerout-Fleury, A.M.2    Barak, I.3    Stragier, P.4
  • 87
    • 0037133943 scopus 로고    scopus 로고
    • Asymmetric cell division in B. subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ
    • Ben-Yehuda S., Losick R. Asymmetric cell division in B. subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ. Cell 2002, 109:257.
    • (2002) Cell , vol.109 , pp. 257
    • Ben-Yehuda, S.1    Losick, R.2
  • 88
    • 0034599494 scopus 로고    scopus 로고
    • Direct interaction between the cell division protein FtsZ and the cell differentiation protein SpoIIE
    • Lucet I., Feucht A., Yudkin M.D., Errington J. Direct interaction between the cell division protein FtsZ and the cell differentiation protein SpoIIE. Embo. J. 2000, 19:1467.
    • (2000) Embo. J. , vol.19 , pp. 1467
    • Lucet, I.1    Feucht, A.2    Yudkin, M.D.3    Errington, J.4
  • 89
    • 0035798360 scopus 로고    scopus 로고
    • Differential gene expression governed by chromosomal spatial asymmetry
    • Dworkin J., Losick R. Differential gene expression governed by chromosomal spatial asymmetry. Cell 2001, 107:339.
    • (2001) Cell , vol.107 , pp. 339
    • Dworkin, J.1    Losick, R.2
  • 90
    • 0033557867 scopus 로고    scopus 로고
    • Transient gene asymmetry during sporulation and establishment of cell specificity in Bacillus subtilis
    • Frandsen N., Barak I., Karmazyn-Campelli C., Stragier P. Transient gene asymmetry during sporulation and establishment of cell specificity in Bacillus subtilis. Gene Dev. 1999, 13:394.
    • (1999) Gene Dev. , vol.13 , pp. 394
    • Frandsen, N.1    Barak, I.2    Karmazyn-Campelli, C.3    Stragier, P.4
  • 91
    • 0034764908 scopus 로고    scopus 로고
    • Self-reinforcing activation of a cell-specific transcription factor by proteolysis of an anti-sigma factor in B. subtilis
    • Pan Q., Garsin D.A., Losick R. Self-reinforcing activation of a cell-specific transcription factor by proteolysis of an anti-sigma factor in B. subtilis. Mol. Cell 2001, 8:873.
    • (2001) Mol. Cell , vol.8 , pp. 873
    • Pan, Q.1    Garsin, D.A.2    Losick, R.3
  • 92
    • 0036270739 scopus 로고    scopus 로고
    • Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
    • Betts J.C., Lukey P.T., Robb L.C., McAdam R.A., Duncan K. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol. Microbiol. 2002, 43:717.
    • (2002) Mol. Microbiol. , vol.43 , pp. 717
    • Betts, J.C.1    Lukey, P.T.2    Robb, L.C.3    McAdam, R.A.4    Duncan, K.5
  • 93
    • 77649141318 scopus 로고    scopus 로고
    • Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia
    • Berney M., Cook G.M. Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia. PLoS One 2010, 5:e8614.
    • (2010) PLoS One , vol.5
    • Berney, M.1    Cook, G.M.2
  • 94
    • 0034903883 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages
    • Manganelli R., Voskuil M.I., Schoolnik G.K., Smith I. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001, 41:423.
    • (2001) Mol. Microbiol. , vol.41 , pp. 423
    • Manganelli, R.1    Voskuil, M.I.2    Schoolnik, G.K.3    Smith, I.4
  • 95
    • 10044266575 scopus 로고    scopus 로고
    • Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli
    • Keren I., Shah D., Spoering A., Kaldalu N., Lewis K. Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. J. Bacteriol. 2004, 186:8172.
    • (2004) J. Bacteriol. , vol.186 , pp. 8172
    • Keren, I.1    Shah, D.2    Spoering, A.3    Kaldalu, N.4    Lewis, K.5
  • 97
    • 0031939281 scopus 로고    scopus 로고
    • Mechanisms of latency in Mycobacterium tuberculosis
    • Parrish N.M., Dick J.D., Bishai W.R. Mechanisms of latency in Mycobacterium tuberculosis. Trend Microbiol. 1998, 6:107.
    • (1998) Trend Microbiol. , vol.6 , pp. 107
    • Parrish, N.M.1    Dick, J.D.2    Bishai, W.R.3
  • 98
    • 55549111608 scopus 로고    scopus 로고
    • The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest
    • Balazsi G., Heath A.P., Shi L., Gennaro M.L. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008, 4:225.
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 225
    • Balazsi, G.1    Heath, A.P.2    Shi, L.3    Gennaro, M.L.4
  • 99
    • 0035940419 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis signal transduction system required for persistent infections
    • Zahrt T.C., Deretic V. Mycobacterium tuberculosis signal transduction system required for persistent infections. Proc. Natl. Acad. Sci. USA 2001, 98:12706.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12706
    • Zahrt, T.C.1    Deretic, V.2
  • 100
    • 0032955397 scopus 로고    scopus 로고
    • Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis
    • Manganelli R., Dubnau E., Tyagi S., Kramer F.R., Smith I. Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis. Mol. Microbiol. 1999, 31:715.
    • (1999) Mol. Microbiol. , vol.31 , pp. 715
    • Manganelli, R.1    Dubnau, E.2    Tyagi, S.3    Kramer, F.R.4    Smith, I.5
  • 102
    • 46349090277 scopus 로고    scopus 로고
    • Positive feedback and noise activate the stringent response regulator rel in mycobacteria
    • Sureka K., Ghosh B., Dasgupta A., Basu J., Kundu M., Bose I. Positive feedback and noise activate the stringent response regulator rel in mycobacteria. PLoS One 2008, 3:e1771.
    • (2008) PLoS One , vol.3
    • Sureka, K.1    Ghosh, B.2    Dasgupta, A.3    Basu, J.4    Kundu, M.5    Bose, I.6
  • 104
    • 0027524272 scopus 로고
    • Regulation of the phosphorelay and the initiation of sporulation in Bacillus subtilis
    • Hoch J.A. Regulation of the phosphorelay and the initiation of sporulation in Bacillus subtilis. Annu. Rev. Microbiol. 1993, 47:441.
    • (1993) Annu. Rev. Microbiol. , vol.47 , pp. 441
    • Hoch, J.A.1
  • 105
    • 0027463845 scopus 로고
    • The phosphorelay signal transduction pathway in the initiation of Bacillus subtilis sporulation
    • Hoch J.A. The phosphorelay signal transduction pathway in the initiation of Bacillus subtilis sporulation. J. Cell Biochem. 1993, 51:55.
    • (1993) J. Cell Biochem. , vol.51 , pp. 55
    • Hoch, J.A.1
  • 106
    • 0027376075 scopus 로고
    • Regulation of the onset of the stationary phase and sporulation in Bacillus subtilis
    • Hoch J.A. Regulation of the onset of the stationary phase and sporulation in Bacillus subtilis. Adv. Microbiol. Physiol. 1993, 35:111.
    • (1993) Adv. Microbiol. Physiol. , vol.35 , pp. 111
    • Hoch, J.A.1
  • 107
    • 33847129667 scopus 로고    scopus 로고
    • Cannibalism and fratricide: mechanisms and raisons d'etre
    • Claverys J.P., Havarstein L.S. Cannibalism and fratricide: mechanisms and raisons d'etre. Nat. Rev. Microbiol. 2007, 5:219.
    • (2007) Nat. Rev. Microbiol. , vol.5 , pp. 219
    • Claverys, J.P.1    Havarstein, L.S.2
  • 108
    • 75749151681 scopus 로고    scopus 로고
    • Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis
    • Lopez D., Kolter R. Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis. F EMS Microbiol Rev. 2009, 34:134.
    • (2009) F EMS Microbiol Rev. , vol.34 , pp. 134
    • Lopez, D.1    Kolter, R.2
  • 109
    • 0028983301 scopus 로고
    • Effects of spo0 mutations on spo0A promoter switching at the initiation of sporulation in Bacillus subtilis
    • Chibazakura T., Kawamura F., Asai K., Takahashi H. Effects of spo0 mutations on spo0A promoter switching at the initiation of sporulation in Bacillus subtilis. J. Bacteriol. 1995, 177:4520.
    • (1995) J. Bacteriol. , vol.177 , pp. 4520
    • Chibazakura, T.1    Kawamura, F.2    Asai, K.3    Takahashi, H.4
  • 110
    • 0030052830 scopus 로고    scopus 로고
    • Determination of cell fate in Bacillus subtilis
    • Errington J. Determination of cell fate in Bacillus subtilis. Trend Genet. 1996, 12:31.
    • (1996) Trend Genet. , vol.12 , pp. 31
    • Errington, J.1
  • 111
    • 1842613501 scopus 로고    scopus 로고
    • Regulation of endospore formation in Bacillus subtilis
    • Errington J. Regulation of endospore formation in Bacillus subtilis. Nat. Rev. Microbiol. 2003, 1:117.
    • (2003) Nat. Rev. Microbiol. , vol.1 , pp. 117
    • Errington, J.1
  • 114
    • 14544290034 scopus 로고    scopus 로고
    • High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis
    • Fujita M., Gonzá¡lez-Pastor J.E., Losick R. High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis. J. Bacteriol. 2005, 187:1357.
    • (2005) J. Bacteriol. , vol.187 , pp. 1357
    • Fujita, M.1    González-Pastor, J.E.2    Losick, R.3
  • 117
    • 1642263410 scopus 로고    scopus 로고
    • AbrB and Spo0E control the proper timing of sporulation in Bacillus subtilis
    • Shafikhani S.H., Leighton T. AbrB and Spo0E control the proper timing of sporulation in Bacillus subtilis. Curr. Microbiol. 2004, 48:262.
    • (2004) Curr. Microbiol. , vol.48 , pp. 262
    • Shafikhani, S.H.1    Leighton, T.2
  • 118
    • 20344374152 scopus 로고    scopus 로고
    • Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis
    • Veening J.-W., Hamoen L.W., Kuipers O.P. Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis. Mol. Microbiol. 2005, 56:1481.
    • (2005) Mol. Microbiol. , vol.56 , pp. 1481
    • Veening, J.-W.1    Hamoen, L.W.2    Kuipers, O.P.3
  • 119
    • 55749092477 scopus 로고    scopus 로고
    • Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis
    • Banse A.V., Chastanet A., Rahn-Lee L., Hobbs E.C., Losick R. Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis. Proc. Natl. Acad. Sci. USA 2008, 105:15547.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 15547
    • Banse, A.V.1    Chastanet, A.2    Rahn-Lee, L.3    Hobbs, E.C.4    Losick, R.5
  • 121
    • 77955302838 scopus 로고    scopus 로고
    • The threshold level of the sensor histidine kinase KinA governs entry into sporulation in Bacillus subtilis
    • Eswaramoorthy P., Duan D., Dinh J., Dravis A., Devi S.N., Fujita M. The threshold level of the sensor histidine kinase KinA governs entry into sporulation in Bacillus subtilis. J. Bacteriol. 2010, 192:3870.
    • (2010) J. Bacteriol. , vol.192 , pp. 3870
    • Eswaramoorthy, P.1    Duan, D.2    Dinh, J.3    Dravis, A.4    Devi, S.N.5    Fujita, M.6
  • 122
    • 24944483644 scopus 로고    scopus 로고
    • Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A
    • Fujita M., Losick R. Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A. Gene Dev. 2005, 19:2236.
    • (2005) Gene Dev. , vol.19 , pp. 2236
    • Fujita, M.1    Losick, R.2
  • 123
    • 77950668896 scopus 로고    scopus 로고
    • Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation
    • de Jong I.G., Veening J.W., Kuipers O.P. Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation. J. Bacteriol. 2010, 192:2053.
    • (2010) J. Bacteriol. , vol.192 , pp. 2053
    • de Jong, I.G.1    Veening, J.W.2    Kuipers, O.P.3
  • 124
    • 77955393111 scopus 로고    scopus 로고
    • Single-cell measurement of the levels and distributions of the phosphorelay components in a population of sporulating Bacillus subtilis cells
    • Eswaramoorthy P., Dinh J., Duan D., Igoshin O.A., Fujita M. Single-cell measurement of the levels and distributions of the phosphorelay components in a population of sporulating Bacillus subtilis cells. Microbiology 2010, 156:2294.
    • (2010) Microbiology , vol.156 , pp. 2294
    • Eswaramoorthy, P.1    Dinh, J.2    Duan, D.3    Igoshin, O.A.4    Fujita, M.5
  • 125
    • 66149121458 scopus 로고    scopus 로고
    • Complexity in bacterial cell-cell communication: quorum signal integration and subpopulation signaling in the Bacillus subtilis phosphorelay
    • Bischofs I.B., Hug J.A., Liu A.W., Wolf D.M., Arkin A.P. Complexity in bacterial cell-cell communication: quorum signal integration and subpopulation signaling in the Bacillus subtilis phosphorelay. Proc. Natl. Acad. Sci. USA 2009, 106:6459.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 6459
    • Bischofs, I.B.1    Hug, J.A.2    Liu, A.W.3    Wolf, D.M.4    Arkin, A.P.5
  • 126
  • 127
    • 85028092051 scopus 로고    scopus 로고
    • Mathematical Modelling of the Sporulation-Initiation Network in Bacillus Subtilis Revealing the Dual Role of the Putative Quorum-Sensing Signal Molecule PhrA
    • Jabbari S., Heap J.T., King J.R. Mathematical Modelling of the Sporulation-Initiation Network in Bacillus Subtilis Revealing the Dual Role of the Putative Quorum-Sensing Signal Molecule PhrA. Bull Math Biol. 2010, 73:181.
    • (2010) Bull Math Biol. , vol.73 , pp. 181
    • Jabbari, S.1    Heap, J.T.2    King, J.R.3
  • 128
    • 1242345225 scopus 로고    scopus 로고
    • Qualitative simulation of the initiation of sporulation in Bacillus subtilis
    • De Jong H., Geiselmann J., Batt G., Hernandez C., Page M. Qualitative simulation of the initiation of sporulation in Bacillus subtilis. Bull. Math. Biol. 2004, 66:261.
    • (2004) Bull. Math. Biol. , vol.66 , pp. 261
    • De Jong, H.1    Geiselmann, J.2    Batt, G.3    Hernandez, C.4    Page, M.5
  • 129
    • 75849116320 scopus 로고    scopus 로고
    • Deciding fate in adverse times: sporulation and competence in Bacillus subtilis
    • Schultz D., Wolynes P.G., Jacob E.B., Onuchic J.N. Deciding fate in adverse times: sporulation and competence in Bacillus subtilis. Proc. Natl. Acad. Sci. USA 2009, 106:21027.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 21027
    • Schultz, D.1    Wolynes, P.G.2    Jacob, E.B.3    Onuchic, J.N.4
  • 131
    • 0000915688 scopus 로고
    • On the relation between the logical structure of systems and their ability to generate multistationarity or sustained oscillations
    • Thomas R. On the relation between the logical structure of systems and their ability to generate multistationarity or sustained oscillations. Springer Ser. Synergetics 1981, 9:180.
    • (1981) Springer Ser. Synergetics , vol.9 , pp. 180
    • Thomas, R.1
  • 134
    • 33744794380 scopus 로고    scopus 로고
    • Regulatory dynamics of synthetic gene networks with positive feedback
    • Maeda Y.T., Sano M. Regulatory dynamics of synthetic gene networks with positive feedback. J. Mol. Biol. 2006, 359:1107.
    • (2006) J. Mol. Biol. , vol.359 , pp. 1107
    • Maeda, Y.T.1    Sano, M.2
  • 135
    • 0036306859 scopus 로고    scopus 로고
    • Positive and negative feedback: striking a balance between necessary antagonists
    • Cinquin O., Demongeot J. Positive and negative feedback: striking a balance between necessary antagonists. J. Theor. Biol. 2002, 216:229.
    • (2002) J. Theor. Biol. , vol.216 , pp. 229
    • Cinquin, O.1    Demongeot, J.2
  • 136
    • 1242274449 scopus 로고    scopus 로고
    • Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems
    • Angeli D., Ferrell J.E., Sontag E.D. Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc. Natl. Acad. Sci. USA 2004, 101:1822.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1822
    • Angeli, D.1    Ferrell, J.E.2    Sontag, E.D.3
  • 137
    • 0036846553 scopus 로고    scopus 로고
    • Alternative designs for a genetic switch: analysis of switching times using the piecewise power-law representation
    • Savageau M.A. Alternative designs for a genetic switch: analysis of switching times using the piecewise power-law representation. Math. Biosci. 2002, 180:237.
    • (2002) Math. Biosci. , vol.180 , pp. 237
    • Savageau, M.A.1
  • 138
    • 18844448417 scopus 로고    scopus 로고
    • Developmental commitment in a bacterium
    • Dworkin J., Losick R. Developmental commitment in a bacterium. Cell 2005, 121:401.
    • (2005) Cell , vol.121 , pp. 401
    • Dworkin, J.1    Losick, R.2
  • 139
  • 140
    • 0033083733 scopus 로고    scopus 로고
    • It's a noisy business! Genetic regulation at the nanomolar scale
    • McAdams H.H., Arkin A. It's a noisy business! Genetic regulation at the nanomolar scale. Trend Genet. 1999, 15:65.
    • (1999) Trend Genet. , vol.15 , pp. 65
    • McAdams, H.H.1    Arkin, A.2
  • 141
    • 2942555282 scopus 로고    scopus 로고
    • Stochastic gene expression in fluctuating environments
    • Thattai M., van Oudenaarden A. Stochastic gene expression in fluctuating environments. Genetics 2004, 167:523.
    • (2004) Genetics , vol.167 , pp. 523
    • Thattai, M.1    van Oudenaarden, A.2
  • 145
    • 0016145568 scopus 로고
    • Comparison of classical and autogenous systems of regulation in inducible operons
    • Savageau M. Comparison of classical and autogenous systems of regulation in inducible operons. Nature 1974, 252:546.
    • (1974) Nature , vol.252 , pp. 546
    • Savageau, M.1
  • 146
    • 0029033413 scopus 로고
    • Subunit structure of regulator proteins influences the design of gene circuitry: analysis of perfectly coupled and completely uncoupled circuits
    • Hlavacek W.S., Savageau M.A. Subunit structure of regulator proteins influences the design of gene circuitry: analysis of perfectly coupled and completely uncoupled circuits. J. Mol. Biol. 1995, 248:739.
    • (1995) J. Mol. Biol. , vol.248 , pp. 739
    • Hlavacek, W.S.1    Savageau, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.