Genetic toggle switch without cooperative binding

Physical Review Letters

Volumn 96, Issue 18, 2006, Pages

  Lipshtat, Azi ^a   Loinger, Adiel ^b   Balaban, Nathalie Q ^b   Biham, Ofer ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

NEURAL NETWORKS; NUMERICAL METHODS; RANDOM PROCESSES;

COOPERATIVE BINDING; GENETIC SWITCH SYSTEMS; NETWORK STRUCTURE; TRANSCRIPTION FACTORS;

SWITCHES;

EID: 33646397850     PISSN: 00319007     EISSN: 10797114     Source Type: Journal    
DOI: 10.1103/PhysRevLett.96.188101     Document Type: Article

References (27)

1. M.B. Elowitz, A.J. Levine, E.D. Siggia, and P.S. Swain, Science 297, 1183 (2002). SCIEAS 0036-8075 10.1126/science.1070919
2. E.M. Ozbudak, M. Thattai, I. Kurtser, A.D. Grossman, and A. van Oudenaarden, Nat. Genet. 31, 69 (2002). NGENEC 1061-4036 10.1038/ng869
3. H.H. McAdams and A. Arkin, Proc. Natl. Acad. Sci. U.S.A. PNASA6 0027-8424 94, 814 (1997); 10.1073/pnas.94.3.814
4. A. Arkin, J. Ross, and H.H. McAdams, Genetics 149, 1633 (1998). GENTAE 0016-6731
5. A. Becskei and L. Serrano, Nature (London) NATUAS 0028-0836 405, 590 (2000). 10.1038/35014651
6. M. Kaern, T.C. Elston, W.J. Blake, and J.J. Collins, Nat. Rev. Genetics 6, 451 (2005).
7. J.M. Vilar, H.Y. Kueh, N. Barkai, and S. Leibler, Proc. Natl. Acad. Sci. U.S.A. PNASA6 0027-8424 99, 5988 (2002); 10.1073/pnas.092133899
8. T. Zhou, L. Chen, and K. Aihara, Phys. Rev. Lett. 95, 178103 (2005). PRLTAO 0031-9007 10.1103/PhysRevLett.95.178103
9. N.M. Shnerb, Y. Louzoun, E. Bettelheim, and S. Solomon, Proc. Natl. Acad. Sci. U.S.A. PNASA6 0027-8424 97, 10322 (2000); 10.1073/pnas.180263697
10. M. Howard and A.D. Rutenberg, Phys. Rev. Lett. 90, 128102 (2003); PRLTAO 0031-9007 10.1103/PhysRevLett.90.128102
11. Y. Togashi and K. Kaneko, Phys. Rev. E 70, 020901 (2004). PLEEE8 1063-651X 10.1103/PhysRevE.70.020901
12. M.R. Atkinson, M.A. Savageau, J.T. Myers, and A.J. Ninfa, Cell 113, 597 (2003); CELLB5 0092-8674 10.1016/S0092-8674(03)00346-5
13. E.M. Ozbudak, M. Thattai, H.N. Lim, B.I. Shraiman, and A. van Oudenaarden, Nature (London) NATUAS 0028-0836 427, 737 (2004); 10.1038/nature02298
14. P. Francois and V. Hakim, Phys. Rev. E 72, 031908 (2005). PLEEE8 1063-651X 10.1103/PhysRevE.72.031908
15. M. Ptashne, A Genetic Switch: Phage λ and Higher Organisms (Cell/Blackwell Scientific, Cambridge, MA, 1992), 2nd ed.
16. T.S. Gardner, C.R. Cantor, and J.J. Collins, Nature (London) NATUAS 0028-0836 403, 339 (2000). 10.1038/35002131
17. J.L. Cherry and F.R. Adler, J. Theor. Biol. 203, 117 (2000). JTBIAP 0022-5193 10.1006/jtbi.2000.1068
18. P.B. Warren and P.R. ten Wolde, Phys. Rev. Lett. 92, 128101 (2004); PRLTAO 0031-9007 10.1103/PhysRevLett.92.128101
19. P.B. Warren P.R. ten Wolde J. Phys. Chem. B 109, 6812 (2005). JPCBFK 1520-6106 10.1021/jp045523y
20. A.M. Walczak, M. Sasai, and P. Wolynes, Biophys. J. BIOJAU 0006-3495 88, 828 (2005). 10.1529/biophysj.104.050666
21. T.B. Kepler and T.C. Elston, Biophys. J. 81, 3116 (2001). BIOJAU 0006-3495
22. A. Lipshtat, H.B. Perets, N.Q. Balaban, and O. Biham, Gene 347, 265 (2005). GENED6 03781119 10.1016/j.gene.2004.12.016
23. J. Paulsson and M. Ehrenberg, Phys. Rev. Lett. 84, 5447 (2000); PRLTAO 0031-9007 10.1103/PhysRevLett.84.5447
24. J. Paulsson, Nature (London) NATUAS 0028-0836 427, 415 (2004). 10.1038/nature02257
25. M.B. Elowitz and S. Leibler, Nature (London) NATUAS 0028-0836 403, 335 (2000). 10.1038/35002125
26. D.T. Gillespie, J. Chem. Phys. 81, 2340 (1977). JCPSA6 0021-9606 10.1021/j100540a008
27. A. Lipshtat and O. Biham, Phys. Rev. Lett. 93, 170601 (2004). PRLTAO 0031-9007 10.1103/PhysRevLett.93.170601