Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A

Genes and Development

Volumn 19, Issue 18, 2005, Pages 2236-2244

  Fujita, Masaya ^a   Losick, Richard ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Bacillus subtilis; Development; Phosphorelay; Response regulator; Sporulation; Transcription

Indexed keywords

FUNCTIONAL GROUP; PROTEIN HISTIDINE KINASE; PROTEIN SPO0A; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; CELL ACTIVITY; CELL CULTURE; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME SYNTHESIS; GENE CONTROL; GENETIC TRANSCRIPTION; NONHUMAN; NUTRIENT LIMITATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPOROGENESIS; TRANSCRIPTION REGULATION;

ARTIFICIAL GENE FUSION; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BETA-GALACTOSIDASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FLUORESCENT DYES; GENE EXPRESSION REGULATION, BACTERIAL; ISOPROPYL THIOGALACTOSIDE; KINETICS; MICROSCOPY, FLUORESCENCE; PHOSPHOTRANSFERASES; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; PYRIDINIUM COMPOUNDS; QUATERNARY AMMONIUM COMPOUNDS; SPORES, BACTERIAL; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS);

EID: 24944483644     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1335705     Document Type: Article

References (31)

1. Ben-Yehuda, S., Rudner, D.Z., and Losick, R. 2003. RacA, a bacterial protein that anchors chromosomes to the cell poles. Science 299: 532-536.
2. Branda, S.S., Gonzalez-Pastor, J.E., Ben-Yehuda, S., Losick, R., and Kolter, R. 2001. Fruiting body formation by Bacillus subtilis. Proc. Natl. Acad. Sci. 98: 11621-11626.
3. Britton, R.A., Eichenberger, P., Gonzalez-Pastor, J.E., Fawcett, P., Monson, R., Losick, R., and Grossman, A.D. 2002. Genome-wide analysis of the stationary-phase σ factor (σ-H) regulon of Bacillus subtilis. J. Bacteriol. 184: 4881-4890.
4. Burbulys, D., Trach, K.A., and Hoch, J.A. 1991. Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay. Cell 64: 545-552.
5. Burkholder, W.F., Kurtser, I., and Grossman, A.D. 2001. Replication initiation proteins regulate a developmental checkpoint in Bacillus subtilis. Cell 104: 269-279.
6. Fabret, C., Feher, V.A., and Hoch, J.A. 1999. Two-component signal transduction in Bacillus subtilis: How one organism sees its world. J. Bacteriol. 181: 1975-1983.
7. Fujita, M. 2000. Temporal and selective association of multiple σ factors with RNA polymerase during sporulation in Bacillus subtilis. Genes Cells 5: 79-88.
8. Fujita, M. and Sadaie, Y. 1998. Feedback loops involving Spo0A and AbrB in in vitro transcription of the genes involved in the initiation of sporulation in Bacillus subtilis. J. Biochem. (Tokyo) 124: 98-104.
9. E in Bacillus subtilis. Mol. Microbiol. 43: 27-38.
10. _. 2003. The master regulator for entry into sporulation in Bacillus subtilis becomes a cell-specific transcription factor after asymmetric division. Genes & Dev. 17: 1166-1174.
11. Fujita, M., Gonzalez-Pastor, J.E., and Losick, R. 2005. High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis. J. Bacteriol. 187: 1357-1368.
12. Gonzalez-Pastor, J.E., Hobbs, E.C., and Losick, R. 2003. Cannibalism by sporulating bacteria. Science 301: 510-513.
13. Hoch, J.A. 1991. spo0 genes, the phosphorelay, and the initiation of sporulation. In Bacillus subtilis and other Grampositive bacteria: Biochemistry, physiology, and molecular genetics (eds. A.L. Sonenshein et al.), pp. 747-755. American Society for Microbiology, Washington, D.C.
14. Hoch, J.A. 1993. Regulation of the phosphorelay and the initiation of sporulation in Bacillus subtilis. Annu. Rev. Microbiol. 47: 441-465.
15. Ireton, K., Rudner, D.Z., Siranosian, K.J., and Grossman, A.D. 1993. Integration of multiple developmental signals in Bacillus subtilis through the Spo0A transcription factor. Genes & Dev. 7: 283-294.
16. Jiang, M., Shao, W., Perego, M., and Hoch, J.A. 2000. Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis. Mol. Microbiol. 38: 535-542.
17. Lopez, J.M., Marks, C.L., and Freese, E. 1979. The decrease of guanine nucleotides initiates sporulation of Bacillus subtilis. Biochim. Biophys. Acta. 587: 238-252.
18. Lopez, J.M., Uratani-Wong, B., and Freese, E. 1980. Catabolite repression of enzyme synthesis does not prevent sporulation. J. Bacteriol. 141: 1447-1449.
19. Molle, V., Fujita, M., Jensen, S.T., Eichenberger, P., Gonzalez-Pastor, J.E., Liu, J.S., and Losick, R. 2003a. The Spo0A regulon of Bacillus subtilis. Mol. Microbiol. 50: 1683-1701.
20. Molle, V., Nakaura, Y., Shivers, R.P., Yamaguchi, H., Losick, R., Fujita, Y., and Sonenshein, A.L. 2003b. Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis. J. Bacteriol. 185: 1911-1922.
21. Perego, M. and Hoch, J.A. 2002. Two-component systems, phosphorelays, and regulation of their activities by phosphatases. In Bacillus subtilis and its closes relatives: From genes to cells (eds. A.L. Sonenshein et al.), pp. 473-481. American Society for Microbiology, Washington, D.C.
22. Piggot, P.J. and Losick, R. 2002. Sporulation genes and intercompartmental regulation. In Bacillus subtilis and its closest relatives: From genes to cells (eds. A.L. Sonenshein et al.), pp. 483-518. American Society for Microbiology, Washington, D.C.
23. H. J. Bacteriol. 174: 2771-2778.
24. Ratnayake-Lecamwasam, M., Serror, P., Wong, K.W., and Sonenshein, A.L. 2001. Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels. Genes & Dev. 15: 1093-1103.
25. H processing enzyme to its inhibitor and dictates its subcellular localization. Genes & Dev. 16: 1007-1018.
26. Sonenshein, A.L. 2005. CodY, a global regulator of stationary phase and virulence in Gram-positive bacteria. Curr. Opin. Microbiol. 8: 203-207.
27. Stephenson, K. and Hoch, J.A. 2002. Evolution of signalling in the sporulation phosphorelay. Mol. Microbiol. 46: 297-304.
28. Sterlini, J.M. and Mandelstam, J. 1969. Commitment to sporulation in Bacillus subtilis and its relationship to development of actinomycin resistance. Biochem. J. 113: 29-37.
29. Stragier, P. and Losick, R. 1996. Molecular genetics of sporulation in Bacillus subtilis. Annu. Rev. Genet. 30: 297-341.
30. Strauch, M.A., Wu, J.J., Jonas, R.H., and Hoch, J.A. 1993. A positive feedback loop controls transcription of the spo0F gene, a component of the sporulation phosphorelay in Bacillus subtilis. Mol. Microbiol. 7: 967-974.
31. Youngman, P.J., Perkins, J.B., and Losick, R. 1983. Genetic transposition and insertional mutagenesis in Bacillus subtilis with Streptococcus faecalis transposon Tn917. Proc. Natl. Acad. Sci. 80: 2305-2309.