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Volumn 5, Issue 1, 2011, Pages 31-42

D-Limonene: A bioactive food component from citrus and evidence for a potential role in breast cancer prevention and treatment

Author keywords

Bioactive food component; Breast cancer; d Limonene; Perillyl alcohol

Indexed keywords

ANTINEOPLASTIC AGENT; CITRUS FRUIT EXTRACT; LIMONENE; PERILLYL ALCOHOL; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79954575341     PISSN: 19705557     EISSN: 19705565     Source Type: Journal    
DOI: 10.1007/s12156-010-0066-8     Document Type: Review
Times cited : (83)

References (77)
  • 1
    • 79954619322 scopus 로고    scopus 로고
    • National Institutes of Health 2008. http://dietary-supplements.info.nih. gov/Research/Bioactive-Food-Components-Initiatives.aspx
    • (2008)
  • 2
    • 68349100034 scopus 로고    scopus 로고
    • Bioactive food components, inflammatory targets, and cancer prevention
    • 10.1158/1940-6207.CAPR-08-0141 1:CAS:528:DC%2BC3cXptVykurw%3D
    • YS Kim MR Young G Bobe NH Colburn JA Milner 2009 Bioactive food components, inflammatory targets, and cancer prevention Cancer Prev Res 2 200 208 10.1158/1940-6207.CAPR-08-0141 1:CAS:528:DC%2BC3cXptVykurw%3D
    • (2009) Cancer Prev Res , vol.2 , pp. 200-208
    • Kim, Y.S.1    Young, M.R.2    Bobe, G.3    Colburn, N.H.4    Milner, J.A.5
  • 3
    • 0037570878 scopus 로고    scopus 로고
    • Biological relevance of terpenoids: Overview focusing on mono-, di- and tetraterpenes
    • DOI 10.1159/000070030
    • KH Wagner I Elmadfa 2003 Biological relevance of terpenoids. Overview focusing on mono-, di- and tetraterpenes Ann Nutr Metab 47 95 106 12743459 10.1159/000070030 1:CAS:528:DC%2BD3sXjslanurs%3D (Pubitemid 36578799)
    • (2003) Annals of Nutrition and Metabolism , vol.47 , Issue.3-4 , pp. 95-106
    • Wagner, K.-H.1    Elmadfa, I.2
  • 4
    • 67349264062 scopus 로고    scopus 로고
    • Terpenoids and breast cancer chemoprevention
    • 18636327 10.1007/s10549-008-0118-y 1:CAS:528:DC%2BD1MXmsVGjsrc%3D
    • T Rabi A Bishayee 2009 Terpenoids and breast cancer chemoprevention Breast Cancer Res Treat 115 223 239 18636327 10.1007/s10549-008-0118-y 1:CAS:528:DC%2BD1MXmsVGjsrc%3D
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 223-239
    • Rabi, T.1    Bishayee, A.2
  • 5
    • 0030867207 scopus 로고    scopus 로고
    • Cancer chemoprevention and therapy by monoterpenes
    • MN Gould 1997 Cancer chemoprevention and therapy by monoterpenes Environ Health Perspect 105 Suppl 4 977 979 9255590 10.2307/3433313 1:CAS:528: DyaK2sXls1elsLs%3D (Pubitemid 27372991)
    • (1997) Environmental Health Perspectives , vol.105 , Issue.SUPPL. 4 , pp. 977-979
    • Gould, M.N.1
  • 6
    • 35348929897 scopus 로고    scopus 로고
    • D-limonene: Safety and clinical applications
    • J Sun 2007 d-Limonene: safety and clinical applications Altern Med Rev 12 259 264 18072821 (Pubitemid 47613223)
    • (2007) Alternative Medicine Review , vol.12 , Issue.3 , pp. 259-264
    • Sun, J.1
  • 7
    • 33744465578 scopus 로고    scopus 로고
    • Lipolytic effects of citrus peel oils and their components
    • DOI 10.1021/jf052409j
    • HS Choi 2006 Lipolytic effects of citrus peel oils and their components J Agric Food Chem 54 3254 3258 16637681 10.1021/jf052409j 1:CAS:528: DC%2BD28Xjt1Kmsbg%3D (Pubitemid 43798193)
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , Issue.9 , pp. 3254-3258
    • Choi, H.-S.1
  • 9
    • 0024519869 scopus 로고
    • The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil
    • TH Maltzman LM Hurt CE Elson MA Tanner MN Gould 1989 The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil Carcinogenesis 10 781 783 2702727 10.1093/carcin/10.4.781 1:CAS:528: DyaL1MXitVGhsb8%3D (Pubitemid 19101303)
    • (1989) Carcinogenesis , vol.10 , Issue.4 , pp. 781-783
    • Maltzman, T.H.1    Hurt, L.M.2    Elson, C.E.3    Tanner, M.A.4    Gould, M.N.5
  • 10
    • 0023870472 scopus 로고
    • Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis
    • CE Elson TH Maltzman JL Boston MA Tanner MN Gould 1988 Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis Carcinogenesis 9 331 332 3123086 10.1093/carcin/9.2.331 1:CAS:528:DyaL1cXktlOitr8%3D (Pubitemid 18038001)
    • (1988) Carcinogenesis , vol.9 , Issue.2 , pp. 331-332
    • Elson, C.E.1    Maltzman, T.H.2    Boston, J.L.3    Tanner, M.A.4    Gould, M.N.5
  • 11
    • 0028229474 scopus 로고
    • Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras
    • 8012978 1:CAS:528:DyaK2cXkslehsbw%3D
    • MN Gould CJ Moore R Zhang B Wang WS Kennan JD Haag 1994 Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras Cancer Res 54 3540 3543 8012978 1:CAS:528:DyaK2cXkslehsbw%3D
    • (1994) Cancer Res , vol.54 , pp. 3540-3543
    • Gould, M.N.1    Moore, C.J.2    Zhang, R.3    Wang, B.4    Kennan, W.S.5    Haag, J.D.6
  • 12
    • 0027950688 scopus 로고
    • Chemoprevention and therapy of cancer by d-limonene
    • PL Crowell MN Gould 1994 Chemoprevention and therapy of cancer by d-limonene Crit Rev Oncog 5 1 22 7948106 1:CAS:528:DyaK2cXmsVCksbY%3D (Pubitemid 2125282)
    • (1994) Critical Reviews in Oncogenesis , vol.5 , Issue.1 , pp. 1-22
    • Crowell, P.L.1    Gould, M.N.2
  • 13
    • 4043135688 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by d-limonene
    • 15237454 1:CAS:528:DC%2BD2cXmslKitLc%3D
    • XG Lu LB Zhan BA Feng MY Qu LH Yu JH Xie 2004 Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by d-limonene World J Gastroenterol 10 2140 2144 15237454 1:CAS:528:DC%2BD2cXmslKitLc%3D
    • (2004) World J Gastroenterol , vol.10 , pp. 2140-2144
    • Lu, X.G.1    Zhan, L.B.2    Feng, B.A.3    Qu, M.Y.4    Yu, L.H.5    Xie, J.H.6
  • 14
    • 0032905653 scopus 로고    scopus 로고
    • Inhibition by D-limonene of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats
    • DOI 10.1016/S0304-3835(98)00340-1, PII S0304383598003401
    • N Uedo M Tatsuta H Iishi M Baba N Sakai H Yano T Otani 1999 Inhibition by d-limonene of gastric carcinogenesis induced by N-methyl-N′-nitro-N- nitrosoguanidine in Wistar rats Cancer Lett 137 131 136 10374833 10.1016/S0304-3835(98)00340-1 1:CAS:528:DyaK1MXitlGqu7c%3D (Pubitemid 29179455)
    • (1999) Cancer Letters , vol.137 , Issue.2 , pp. 131-136
    • Uedo, N.1    Tatsuta, M.2    Iishi, H.3    Baba, M.4    Sakai, N.5    Yano, H.6    Otani, T.7
  • 15
    • 0035427196 scopus 로고    scopus 로고
    • ras plasma membrane association
    • DOI 10.1002/ijc.1353
    • I Kaji M Tatsuta H Iishi M Baba A Inoue H Kasugai 2001 Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane association Int J Cancer 93 441 444 11433412 10.1002/ijc.1353 1:CAS:528:DC%2BD3MXlt12gsbc%3D (Pubitemid 32592066)
    • (2001) International Journal of Cancer , vol.93 , Issue.3 , pp. 441-444
    • Kaji, I.1    Tatsuta, M.2    Iishi, H.3    Baba, M.4    Inoue, A.5    Kasugai, H.6
  • 16
    • 0033194729 scopus 로고    scopus 로고
    • D-Limonene chemoprevention of hepatocarcinogenesis in AKR mice: Inhibition of c-jun and c-myc
    • 10425313 1:CAS:528:DyaK1MXlsFegsbY%3D
    • RK Giri T Parija BR Das 1999 d-Limonene chemoprevention of hepatocarcinogenesis in AKR mice: inhibition of c-jun and c-myc Oncol Rep 6 1123 1127 10425313 1:CAS:528:DyaK1MXlsFegsbY%3D
    • (1999) Oncol Rep , vol.6 , pp. 1123-1127
    • Giri, R.K.1    Parija, T.2    Das, B.R.3
  • 17
    • 0141782301 scopus 로고    scopus 로고
    • Effect of naturally occurring monoterpenes Carvone, limonene and perillic acid in the inhibition of experimental lung metastasis induced by B16F-10 melanoma cells
    • TJ Raphael G Kuttan 2003 Effect of naturally occurring monoterpenes carvone, limonene and perillic acid in the inhibition of experimental lung metastasis induced by B16F-10 melanoma cells J Exp Clin Cancer Res 22 419 424 14582701 1:CAS:528:DC%2BD3sXpt1Grtb4%3D (Pubitemid 37205399)
    • (2003) Journal of Experimental and Clinical Cancer Research , vol.22 , Issue.3 , pp. 419-424
    • Raphael, T.J.1    Kuttan, G.2
  • 18
    • 67649484490 scopus 로고    scopus 로고
    • D-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
    • 19465777 10.4103/1477-3163.51368
    • T Rabi A Bishayee 2009 d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: generation of reactive oxygen species and induction of apoptosis J Carcinog 8 9 19465777 10.4103/1477-3163. 51368
    • (2009) J Carcinog , vol.8 , pp. 9
    • Rabi, T.1    Bishayee, A.2
  • 19
    • 77952978785 scopus 로고    scopus 로고
    • Through a glass darkly: Advances in understanding breast cancer biology, 2000-2010
    • Carey LA (2010) Through a glass darkly: advances in understanding breast cancer biology, 2000-2010. Clin Breast Cancer 10:188-195
    • (2010) Clin Breast Cancer , vol.10 , pp. 188-195
    • Carey, L.A.1
  • 21
    • 0031834303 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer
    • DOI 10.1007/s002800050793
    • DM Vigushin GK Poon A Boddy J English GW Halbert C Pagonis M Jarman RC Coombes 1998 Phase I and pharmacokinetic study of d-limonene in patients with advanced cancer Cancer Research Campaign Phase I/II Clinical Trials Committee Cancer Chemother Pharmacol 42 111 117 9654110 10.1007/s002800050793 1:CAS:528:DyaK1cXjslWmurw%3D (Pubitemid 28267291)
    • (1998) Cancer Chemotherapy and Pharmacology , vol.42 , Issue.2 , pp. 111-117
    • Vigushin, D.M.1    Poon, G.K.2    Boddy, A.3    English, J.4    Halbert, G.W.5    Pagonis, C.6    Jarman, M.7    Coombes, R.C.8
  • 22
    • 0029868653 scopus 로고    scopus 로고
    • Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry
    • GK Poon D Vigushin LJ Griggs MG Rowlands RC Coombes M Jarman 1996 Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry Drug Metab Dispos 24 565 571 8723738 1:CAS:528:DyaK28XivVOnu7s%3D (Pubitemid 26146701)
    • (1996) Drug Metabolism and Disposition , vol.24 , Issue.5 , pp. 565-571
    • Poon, G.K.1    Vigushin, D.2    Griggs, L.J.3    Rowlands, M.G.4    Coombes, R.C.5    Jarman, M.6
  • 23
    • 0031742724 scopus 로고    scopus 로고
    • Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines
    • S Bardon K Picard P Martel 1998 Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines Nutr Cancer 32 1 7 9824849 10.1080/01635589809514708 1:CAS:528: DyaK1cXnslSqur4%3D (Pubitemid 28519235)
    • (1998) Nutrition and Cancer , vol.32 , Issue.1 , pp. 1-7
    • Bardon, S.1    Picard, K.2    Martel, P.3
  • 24
    • 0027965512 scopus 로고
    • Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene
    • DOI 10.1007/s002800050176
    • JD Haag MN Gould 1994 Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene Cancer Chemother Pharmacol 34 477 483 7923558 10.1007/BF00685658 1:CAS:528:DyaK2MXis1Onu7k%3D (Pubitemid 24306046)
    • (1994) Cancer Chemotherapy and Pharmacology , vol.34 , Issue.6 , pp. 477-483
    • Haag, J.D.1    Gould, M.N.2
  • 25
    • 0030757145 scopus 로고    scopus 로고
    • Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells
    • DOI 10.1016/S0006-2952(97)00151-2, PII S0006295297001512
    • Z Ren CE Elson MN Gould 1997 Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells Biochem Pharmacol 54 113 120 9296357 10.1016/S0006-2952(97)00151-2 1:CAS:528:DyaK2sXlsVGqu74%3D (Pubitemid 27353228)
    • (1997) Biochemical Pharmacology , vol.54 , Issue.1 , pp. 113-120
    • Ren, Z.1    Elson, C.E.2    Gould, M.N.3
  • 27
    • 0027199916 scopus 로고
    • Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor β1 levels during monoterpene-induced regression of mammary tumors
    • RL Jirtle JD Haag EA Ariazi MN Gould 1993 Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors Cancer Res 53 3849 3852 8358708 1:CAS:528:DyaK2cXhvVw%3D (Pubitemid 23267674)
    • (1993) Cancer Research , vol.53 , Issue.17 , pp. 3849-3852
    • Jirtle, R.L.1    Haag, J.D.2    Ariazi, E.A.3    Gould, M.N.4
  • 31
    • 77955009350 scopus 로고    scopus 로고
    • Adipose tissue accumulation of d-limonene with the consumption of a lemonade preparation rich in d-limonene content
    • Miller JA, Hakim IA, Chew W, Thompson P, Thomson CA, Chow SH-H (2010) Adipose tissue accumulation of d-limonene with the consumption of a lemonade preparation rich in d-limonene content. Nutr Cancer 62(6):783-788
    • (2010) Nutr Cancer , vol.62 , Issue.6 , pp. 783-788
    • Miller, J.A.1    Hakim, I.A.2    Chew, W.3    Thompson, P.4    Thomson, C.A.5    Sh-H, C.6
  • 32
    • 40349094954 scopus 로고    scopus 로고
    • Inflammation and breast cancer balancing immune response: Crosstalk between adaptive and innate immune cells during breast cancer progression
    • 17705880 10.1186/bcr1746
    • DG DeNardo LM Coussens 2007 Inflammation and breast cancer balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression Breast Cancer Res 9 212 17705880 10.1186/bcr1746
    • (2007) Breast Cancer Res , vol.9 , pp. 212
    • Denardo, D.G.1    Coussens, L.M.2
  • 33
    • 35648948315 scopus 로고    scopus 로고
    • Immunology and breast cancer: Therapeutic cancer vaccines
    • DOI 10.1016/j.breast.2007.07.004, PII S0960977607001269
    • G Curigliano M Rescigno A Goldhirsch 2007 Immunology and breast cancer: therapeutic cancer vaccines Breast 16 Suppl 2 S20 S26 17706425 10.1016/j.breast.2007.07.004 (Pubitemid 350028551)
    • (2007) Breast , vol.16 , Issue.2 SUPPL. , pp. 20-26
    • Curigliano, G.1    Rescigno, M.2    Goldhirsch, A.3
  • 36
    • 0037570716 scopus 로고    scopus 로고
    • Immunomodulatory activity of naturally occurring monoterpenes carvone, limonene, and perillic acid
    • DOI 10.1081/IPH-120020476
    • TJ Raphael G Kuttan 2003 Immunomodulatory activity of naturally occurring monoterpenes carvone, limonene, and perillic acid Immunopharmacol Immunotoxicol 25 285 294 12784919 10.1081/IPH-120020476 1:CAS:528:DC%2BD3sXkslKrt7w%3D (Pubitemid 36597423)
    • (2003) Immunopharmacology and Immunotoxicology , vol.25 , Issue.2 , pp. 285-294
    • Raphael, T.J.1    Kuttan, G.2
  • 37
    • 46849096064 scopus 로고    scopus 로고
    • Cancer vaccines: On the threshold of success
    • DOI 10.1517/14728214.13.2.295
    • LA Emens 2008 Cancer vaccines: on the threshold of success Expert Opin Emerg Drugs 13 295 308 18537522 10.1517/14728214.13.2.295 1:CAS:528: DC%2BD1cXmvVCktLk%3D (Pubitemid 351957349)
    • (2008) Expert Opinion on Emerging Drugs , vol.13 , Issue.2 , pp. 295-308
    • Emens, L.A.1
  • 38
    • 38449104646 scopus 로고    scopus 로고
    • Cancer vaccines: A new frontier in prevention and treatment
    • 18154203 discussion 18
    • E Giarelli 2007 Cancer vaccines: a new frontier in prevention and treatment Oncology 21 11 17 18154203 discussion 18
    • (2007) Oncology , vol.21 , pp. 11-17
    • Giarelli, E.1
  • 39
    • 0025741216 scopus 로고
    • Characterization of effective chemopreventive agents in mammary gland in vitro using an initiation-promotion protocol
    • 1905902 1:CAS:528:DyaK3MXlt1KmtrY%3D
    • RG Mehta RC Moon 1991 Characterization of effective chemopreventive agents in mammary gland in vitro using an initiation-promotion protocol Anticancer Res 11 593 596 1905902 1:CAS:528:DyaK3MXlt1KmtrY%3D
    • (1991) Anticancer Res , vol.11 , pp. 593-596
    • Mehta, R.G.1    Moon, R.C.2
  • 41
    • 0034458438 scopus 로고    scopus 로고
    • Rat models of premalignant breast disease
    • DOI 10.1023/A:1009582012493
    • HJ Thompson M Singh 2000 Rat models of premalignant breast disease J Mammary Gland Biol Neoplasia 5 409 420 14973385 10.1023/A:1009582012493 1:STN:280:DC%2BD2c%2FosFWrtg%3D%3D (Pubitemid 32236771)
    • (2000) Journal of Mammary Gland Biology and Neoplasia , vol.5 , Issue.4 , pp. 409-420
    • Thompson, H.J.1    Singh, M.2
  • 42
    • 50449087873 scopus 로고    scopus 로고
    • The effect of initiating doses of benzo[a]pyrene and 7,12-dimethylbenz[a] anthracene on the expression of PAH activating enzymes and its modulation by plant phenols
    • 18694800 10.1016/j.tox.2008.07.047 1:CAS:528:DC%2BD1cXhtV2jtrjF
    • H Szaefer V Krajka-Kuzniak W Baer-Dubowska 2008 The effect of initiating doses of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene on the expression of PAH activating enzymes and its modulation by plant phenols Toxicology 251 28 34 18694800 10.1016/j.tox.2008.07.047 1:CAS:528:DC%2BD1cXhtV2jtrjF
    • (2008) Toxicology , vol.251 , pp. 28-34
    • Szaefer, H.1    Krajka-Kuzniak, V.2    Baer-Dubowska, W.3
  • 43
    • 0030742936 scopus 로고    scopus 로고
    • In vitro inhibition of CYP2B1 monooxygenase by β-myrcene and other monoterpenoid compounds
    • DOI 10.1016/S0378-4274(97)00034-9, PII S0378427497000349
    • AC De-Oliveira LF Ribeiro-Pinto JR Paumgartten 1997 In vitro inhibition of CYP2B1 monooxygenase by beta-myrcene and other monoterpenoid compounds Toxicol Lett 92 39 46 9242356 10.1016/S0378-4274(97)00034-9 1:CAS:528: DyaK2sXkvFanu7k%3D (Pubitemid 27289494)
    • (1997) Toxicology Letters , vol.92 , Issue.1 , pp. 39-46
    • De-Oliveira, A.C.A.X.1    Ribeiro-Pinto, L.F.2    Paumgartten, F.J.R.3
  • 45
    • 0034490969 scopus 로고    scopus 로고
    • Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid
    • A Murakami Y Nakamura Y Ohto M Yano T Koshiba K Koshimizu H Tokuda H Nishino H Ohigashi 2000 Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid Biofactors 12 187 192 11216485 10.1002/biof.5520120130 1:CAS:528:DC%2BD3MXhsFegu7o%3D (Pubitemid 32107406)
    • (2000) BioFactors , vol.12 , Issue.1-4 , pp. 187-192
    • Murakami, A.1    Nakamura, Y.2    Ohto, Y.3    Yano, M.4    Koshiba, T.5    Koshimizu, K.6    Tokuda, H.7    Nishino, H.8    Ohigashi, H.9
  • 47
    • 73649125345 scopus 로고    scopus 로고
    • Antioxidant activity of limonene on normal murine lymphocytes: Relation to HO modulation and cell proliferation
    • Roberto D, Micucci P, Sebastian T, Graciela F, Anesini C (2009) Antioxidant activity of limonene on normal murine lymphocytes: relation to HO modulation and cell proliferation. Basic Clin Pharmacol Toxicol 106:38-44
    • (2009) Basic Clin Pharmacol Toxicol , vol.106 , pp. 38-44
    • Roberto, D.1    Micucci, P.2    Sebastian, T.3    Graciela, F.4    Anesini, C.5
  • 48
    • 0029055687 scopus 로고
    • The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol
    • 7767906 10.1016/0304-3835(95)03747-K 1:CAS:528:DyaK2MXlvVSqs70%3D
    • MH Gelb F Tamanoi K Yokoyama F Ghomashchi K Esson MN Gould 1995 The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol Cancer Lett 91 169 175 7767906 10.1016/0304-3835(95)03747-K 1:CAS:528:DyaK2MXlvVSqs70%3D
    • (1995) Cancer Lett , vol.91 , pp. 169-175
    • Gelb, M.H.1    Tamanoi, F.2    Yokoyama, K.3    Ghomashchi, F.4    Esson, K.5    Gould, M.N.6
  • 49
    • 0025952954 scopus 로고
    • Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites
    • PL Crowell RR Chang ZB Ren CE Elson MN Gould 1991 Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites J Biol Chem 266 17679 17685 1894647 1:CAS:528:DyaK3MXltVGlsL8%3D (Pubitemid 21907991)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.26 , pp. 17679-17685
    • Crowell, P.L.1    Chang, R.R.2    Ren, Z.3    Elson, C.E.4    Gould, M.N.5
  • 51
    • 11144276541 scopus 로고    scopus 로고
    • Radiation sensitization by inhibition of activated Ras
    • DOI 10.1007/s00066-004-9198-8
    • TB Brunner SM Hahn WG McKenna EJ Bernhard 2004 Radiation sensitization by inhibition of activated Ras Strahlenther Onkol 180 731 740 15549191 10.1007/s00066-004-9198-8 (Pubitemid 40022280)
    • (2004) Strahlentherapie und Onkologie , vol.180 , Issue.11 , pp. 731-740
    • Brunner, T.B.1    Hahn, S.M.2    McKenna, W.G.3    Bernhard, E.J.4
  • 52
    • 3042736080 scopus 로고    scopus 로고
    • Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention
    • H Mo CE Elson 2004 Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention Exp Biol Med 229 567 585 1:CAS:528:DC%2BD2cXlslWqsL8%3D (Pubitemid 38878903)
    • (2004) Experimental Biology and Medicine , vol.229 , Issue.7 , pp. 567-585
    • Mo, H.1    Elson, C.E.2
  • 53
    • 26444574802 scopus 로고    scopus 로고
    • Development of farnesyl transferase inhibitors: A review
    • DOI 10.1634/theoncologist.10-8-565
    • NM Appels JH Beijnen JH Schellens 2005 Development of farnesyl transferase inhibitors: a review Oncologist 10 565 578 16177281 10.1634/theoncologist.10-8-565 (Pubitemid 41429120)
    • (2005) Oncologist , vol.10 , Issue.8 , pp. 565-578
    • Appels, N.M.G.M.1    Beijnen, J.H.2    Schellens, J.H.M.3
  • 54
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • JL Bos 1989 Ras oncogenes in human cancer: a review Cancer Res 49 4682 4689 2547513 1:CAS:528:DyaL1MXltlWksL4%3D (Pubitemid 19213607)
    • (1989) Cancer Research , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 55
    • 3042581811 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors: The next targeted therapies for breast cancer?
    • DOI 10.1677/erc.0.0110191
    • RM O'Regan FR Khuri 2004 Farnesyl transferase inhibitors: the next targeted therapies for breast cancer? Endocr Relat Cancer 11 191 205 15163298 10.1677/erc.0.0110191 (Pubitemid 38842410)
    • (2004) Endocrine-Related Cancer , vol.11 , Issue.2 , pp. 191-205
    • O'Regan, R.M.1    Khuri, F.R.2
  • 56
    • 0026636635 scopus 로고
    • Limonene-induced regression of mammary carcinomas
    • 1617679 1:CAS:528:DyaK38Xks1amsLo%3D
    • JD Haag MJ Lindstrom MN Gould 1992 Limonene-induced regression of mammary carcinomas Cancer Res 52 4021 4026 1617679 1:CAS:528:DyaK38Xks1amsLo%3D
    • (1992) Cancer Res , vol.52 , pp. 4021-4026
    • Haag, J.D.1    Lindstrom, M.J.2    Gould, M.N.3
  • 57
    • 0028263020 scopus 로고
    • Effectiveness of combined limonene and 4-hydroxyandrostenedione in the treatment of NMU-induced rat mammary tumours
    • SK Chander AG Lansdown YA Luqmani JJ Gomm RC Coope N Gould RC Coombes 1994 Effectiveness of combined limonene and 4-hydroxyandrostenedione in the treatment of NMU-induced rat mammary tumours Br J Cancer 69 879 882 8180018 10.1038/bjc.1994.170 1:CAS:528:DyaK2cXls12ru78%3D (Pubitemid 24140668)
    • (1994) British Journal of Cancer , vol.69 , Issue.5 , pp. 879-882
    • Chander, S.K.1    Lansdown, A.G.B.2    Luqmani, Y.A.3    Gomm, J.J.4    Coope, R.C.5    Gould, N.6    Coombes, R.C.7
  • 58
    • 58149236744 scopus 로고    scopus 로고
    • Roles of TGFbeta in metastasis
    • 19050696 10.1038/cr.2008.316 1:CAS:528:DC%2BD1MXht1GgsA%3D%3D
    • D Padua J Massague 2009 Roles of TGFbeta in metastasis Cell Res 19 89 102 19050696 10.1038/cr.2008.316 1:CAS:528:DC%2BD1MXht1GgsA%3D%3D
    • (2009) Cell Res , vol.19 , pp. 89-102
    • Padua, D.1    Massague, J.2
  • 59
    • 77952828838 scopus 로고    scopus 로고
    • Targeting fibroblast growth factor receptors blocks PI3 K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis
    • Dey JH, Bianchi F, Voshol J, Bonenfant D, Oakeley EJ, Hynes NE (2010) Targeting fibroblast growth factor receptors blocks PI3 K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis. Cancer Res 70:4151-4162
    • (2010) Cancer Res , vol.70 , pp. 4151-4162
    • Dey, J.H.1    Bianchi, F.2    Voshol, J.3    Bonenfant, D.4    Oakeley, E.J.5    Hynes, N.E.6
  • 60
    • 77953541212 scopus 로고    scopus 로고
    • Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis
    • Hsieh CC, Hernandez-Ledesma B, de Lumen BO (2010) Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact 186:127-134
    • (2010) Chem Biol Interact , vol.186 , pp. 127-134
    • Hsieh, C.C.1    Hernandez-Ledesma, B.2    De Lumen, B.O.3
  • 61
    • 45849149235 scopus 로고    scopus 로고
    • Determination of d-limonene in adipose tissue by gas chromatography-mass spectrometry
    • 18571481 10.1016/j.jchromb.2008.06.002 1:CAS:528:DC%2BD1cXotlOjsbk%3D
    • JA Miller IA Hakim C Thomson P Thompson HH Chow 2008 Determination of d-limonene in adipose tissue by gas chromatography-mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci 870 68 73 18571481 10.1016/j.jchromb.2008.06.002 1:CAS:528:DC%2BD1cXotlOjsbk%3D
    • (2008) J Chromatogr B Analyt Technol Biomed Life Sci , vol.870 , pp. 68-73
    • Miller, J.A.1    Hakim, I.A.2    Thomson, C.3    Thompson, P.4    Chow, H.H.5
  • 62
    • 54149111527 scopus 로고    scopus 로고
    • Bioequivalence evaluation of two d-limonene capsule formulations in healthy Chinese volunteers
    • 18972832 1:CAS:528:DC%2BD1cXht1GmsbvF
    • T Liu Y Guo Z Gao Z Chen X Jiang 2008 Bioequivalence evaluation of two d-limonene capsule formulations in healthy Chinese volunteers Pharmazie 63 718 720 18972832 1:CAS:528:DC%2BD1cXht1GmsbvF
    • (2008) Pharmazie , vol.63 , pp. 718-720
    • Liu, T.1    Guo, Y.2    Gao, Z.3    Chen, Z.4    Jiang, X.5
  • 63
    • 0032145829 scopus 로고    scopus 로고
    • Pharmacokinetics of d-limonene in the rat by GC-MS assay
    • DOI 10.1016/S0731-7085(97)00243-4, PII S0731708597002434
    • H Chen KK Chan T Budd 1998 Pharmacokinetics of d-limonene in the rat by GC-MS assay J Pharm Biomed Anal 17 631 640 9682146 10.1016/S0731-7085(97)00243-4 1:CAS:528:DyaK1cXkvFWhsb4%3D (Pubitemid 28302688)
    • (1998) Journal of Pharmaceutical and Biomedical Analysis , vol.17 , Issue.4-5 , pp. 631-640
    • Chen, H.1    Chan, K.K.2    Budd, T.3
  • 64
    • 0026763155 scopus 로고
    • Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene
    • 1638695 10.1093/carcin/13.7.1261 1:CAS:528:DyaK38Xls1egt7c%3D
    • PL Crowell WS Kennan JD Haag S Ahmad E Vedejs MN Gould 1992 Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene Carcinogenesis 13 1261 1264 1638695 10.1093/carcin/13.7.1261 1:CAS:528:DyaK38Xls1egt7c%3D
    • (1992) Carcinogenesis , vol.13 , pp. 1261-1264
    • Crowell, P.L.1    Kennan, W.S.2    Haag, J.D.3    Ahmad, S.4    Vedejs, E.5    Gould, M.N.6
  • 65
    • 39749147839 scopus 로고    scopus 로고
    • Molecular basis of invasion in breast cancer
    • 17957337 10.1007/s00018-007-7388-0 1:CAS:528:DC%2BD1cXmtVyltA%3D%3D
    • EA McSherry S Donatello AM Hopkins S McDonnell 2007 Molecular basis of invasion in breast cancer Cell Mol Life Sci 64 3201 3218 17957337 10.1007/s00018-007-7388-0 1:CAS:528:DC%2BD1cXmtVyltA%3D%3D
    • (2007) Cell Mol Life Sci , vol.64 , pp. 3201-3218
    • McSherry, E.A.1    Donatello, S.2    Hopkins, A.M.3    McDonnell, S.4
  • 66
    • 0033637602 scopus 로고    scopus 로고
    • Citrus peel use is associated with reduced risk of squamous cell carcinoma of the skin
    • 11142088 10.1207/S15327914NC372-7 1:STN:280:DC%2BD3Mrks1Chsw%3D%3D
    • IA Hakim RB Harris C Ritenbaugh 2000 Citrus peel use is associated with reduced risk of squamous cell carcinoma of the skin Nutr Cancer 37 161 168 11142088 10.1207/S15327914NC372-7 1:STN:280:DC%2BD3Mrks1Chsw%3D%3D
    • (2000) Nutr Cancer , vol.37 , pp. 161-168
    • Hakim, I.A.1    Harris, R.B.2    Ritenbaugh, C.3
  • 67
    • 0642275796 scopus 로고    scopus 로고
    • Joint effects of citrus peel use and black tea intake on the risk of squamous cell carcinoma of the skin
    • DOI 10.1186/1471-5945-1-3
    • IA Hakim RB Harris 2001 Joint effects of citrus peel use and black tea intake on the risk of squamous cell carcinoma of the skin BMC Dermatol 1 3 11527506 10.1186/1471-5945-1-3 1:STN:280:DC%2BD3srgs1Whsg%3D%3D (Pubitemid 38750943)
    • (2001) BMC Dermatology , vol.1 , pp. 3
    • Hakim, I.A.1    Harris, R.B.2
  • 68
    • 33846643550 scopus 로고    scopus 로고
    • Construction of a flavonoid database for assessing intake in a population-based sample of women on Long Island, New York
    • DOI 10.1207/s15327914nc5601-8
    • BN Fink SE Steck MS Wolff GC Kabat MD Gammon 2006 Construction of a flavonoid database for assessing intake in a population-based sample of women on Long Island, New York Nutr Cancer 56 57 66 17176218 10.1207/s15327914nc5601-8 1:CAS:528:DC%2BD2sXhvVOmsLY%3D (Pubitemid 46173414)
    • (2006) Nutrition and Cancer , vol.56 , Issue.1 , pp. 57-66
    • Fink, B.N.1    Steck, S.E.2    Wolff, M.S.3    Kabat, G.C.4    Gammon, M.D.5
  • 70
    • 33750894253 scopus 로고    scopus 로고
    • Dietary fat, fiber, vegetable, and micronutrients are associated with overall survival in postmenopausal women diagnosed with breast cancer
    • DOI 10.1207/s15327914nc5502-3
    • AJ McEligot J Largent A Ziogas D Peel H Anton-Culver 2006 Dietary fat, fiber, vegetable, and micronutrients are associated with overall survival in postmenopausal women diagnosed with breast cancer Nutr Cancer 55 132 140 17044767 10.1207/s15327914nc5502-3 1:CAS:528:DC%2BD28XhtlentLvJ (Pubitemid 44719626)
    • (2006) Nutrition and Cancer , vol.55 , Issue.2 , pp. 132-140
    • McEligot, A.J.1    Largent, J.2    Ziogas, A.3    Peel, D.4    Anton-Culver, H.5
  • 71
    • 0033939144 scopus 로고    scopus 로고
    • Low intakes of vegetables and fruits, especially citrus fruits, lead to inadequate vitamin C intakes among adults
    • DOI 10.1038/sj.ejcn.1601059
    • CA Taylor JS Hampl CS Johnston 2000 Low intakes of vegetables and fruits, especially citrus fruits, lead to inadequate vitamin C intakes among adults Eur J Clin Nutr 54 573 578 10918468 10.1038/sj.ejcn.1601059 1:STN:280: DC%2BD3M%2FpsFWrtQ%3D%3D (Pubitemid 30447325)
    • (2000) European Journal of Clinical Nutrition , vol.54 , Issue.7 , pp. 573-578
    • Taylor, C.A.1    Hampl, J.S.2    Johnston, C.S.3
  • 73
    • 0037882042 scopus 로고    scopus 로고
    • Intake of fruits, vegetables and selected micronutrients in relation to the risk of breast cancer
    • DOI 10.1002/ijc.11088
    • AS Malin D Qi XO Shu YT Gao JM Friedmann F Jin W Zheng 2003 Intake of fruits, vegetables and selected micronutrients in relation to the risk of breast cancer Int J Cancer 105 413 418 12704679 10.1002/ijc.11088 1:CAS:528: DC%2BD3sXktlWitrc%3D (Pubitemid 36570057)
    • (2003) International Journal of Cancer , vol.105 , Issue.3 , pp. 413-418
    • Malin, A.S.1    Qi, D.2    Shu, X.-O.3    Gao, Y.-T.4    Friedmann, J.M.5    Jin, F.6    Zheng, W.7
  • 74
    • 0038310626 scopus 로고    scopus 로고
    • Adherence to a Mediterranean diet and survival in a Greek population
    • DOI 10.1056/NEJMoa025039
    • A Trichopoulou T Costacou C Bamia D Trichopoulos 2003 Adherence to a Mediterranean diet and survival in a Greek population N Engl J Med 348 2599 2608 12826634 10.1056/NEJMoa025039 (Pubitemid 36741587)
    • (2003) New England Journal of Medicine , vol.348 , Issue.26 , pp. 2599-2608
    • Trichopoulou, A.1    Costacou, T.2    Bamia, C.3    Trichopoulos, D.4
  • 75
    • 5044220922 scopus 로고    scopus 로고
    • Mediterranean diet and cancer risk
    • DOI 10.1097/00008469-200410000-00013
    • S Gallus C Bosetti C La Vecchia 2004 Mediterranean diet and cancer risk Eur J Cancer Prev 13 447 452 15452458 10.1097/00008469-200410000-00013 1:STN:280:DC%2BD2crjt1eqtw%3D%3D (Pubitemid 39336610)
    • (2004) European Journal of Cancer Prevention , vol.13 , Issue.5 , pp. 447-452
    • Gallus, S.1    Bosetti, C.2    La Vecchia, C.3
  • 76
    • 0001768949 scopus 로고    scopus 로고
    • Assessing dietary d-limonene intake for epidemiological studies
    • 10.1006/jfca.1999.0862 1:CAS:528:DC%2BD3cXntVWnsr4%3D
    • IAMT Hakim D Liebler 2000 Assessing dietary d-limonene intake for epidemiological studies J Food Compos Anal 13 329 336 10.1006/jfca.1999.0862 1:CAS:528:DC%2BD3cXntVWnsr4%3D
    • (2000) J Food Compos Anal , vol.13 , pp. 329-336
    • Iamt, H.1    Liebler, D.2
  • 77
    • 0035857732 scopus 로고    scopus 로고
    • The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities
    • DOI 10.1016/S0378-5173(00)00699-2, PII S0378517300006992
    • AF El-Kattan CS Asbill N Kim BB Michniak 2001 The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities Int J Pharm 215 229 240 11250108 10.1016/S0378-5173(00)00699-2 1:CAS:528:DC%2BD3MXhslelurg%3D (Pubitemid 32206620)
    • (2001) International Journal of Pharmaceutics , vol.215 , Issue.1-2 , pp. 229-240
    • El-Kattan, A.F.1    Asbill, C.S.2    Kim, N.3    Michniak, B.B.4


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