In vitro inhibition of CYP2B1 monooxygenase by β-myrcene and other monoterpenoid compounds

Toxicology Letters

Volumn 92, Issue 1, 1997, Pages 39-46

  De Oliveira, Ana C A X ^a   Ribeiro Pinto, Luis F ^b   Paumgartten, Francisco J R ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Antimutagenesis; Cytochrome P450; Essential oils; Metabolic activation; Monoterpenes; Xenobiotic biotransformation

Indexed keywords

CAMPHOR; CITRAL; CITRONELLAL; CYTOCHROME P450 ISOENZYME; LIMONENE; MYRCENE; PHENOBARBITAL; PINENE; TERPENE; TERPINENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GENOTOXICITY; IN VITRO STUDY; LIVER MICROSOME; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; ENZYME INHIBITORS; FEMALE; FOOD ADDITIVES; KINETICS; MICROSOMES, LIVER; MONOTERPENES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES;

ANIMALIA; CYMBOPOGON CITRATUS; DRYOBALANOPS; HUMULUS; VERBENA;

EID: 0030742936     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(97)00034-9     Document Type: Article

References (21)

1. Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
2. Burke, M.D., Thompson, S., Elcombe, C.R., Halpert, J., Haaparanta, T., Mayer, R.T., 1985. Ethoxy- pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450. Biochem. Pharmacol. 34, 3337-3345.
3. Burke, M.D., Thompson, S., Weaver, R.J., Wolf, C.R., Mayer, R.T., 1994. Cytochrome P450 specificities of alkoxyresorufin-O-dealkylation in human and rat liver. Biochem. Pharmacol. 48, 923-936.
4. Doehmer, J., Dogra, S., Friedberg, T., Monier, S., Adesnik, M., Glatt, H., Oesch, F., 1988. Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1. Proc. Natl. Acad. Sci. USA 85, 6769-6773.
5. Erickson, R.E., 1976. The industrial importance of monoterpenes and essential oils. Lloydia 39, 8-19.
6. Freitas, J.C.B.R., Presgrave, O.A.F., Fingola, F.F., Menezes, M.A.C. and Paumgartten, F.J.R., 1993. Effect of β-myrcene on pentobarbital sleeping time. Braz. J. Med. Biol. Res. 26, 519-523.
7. Günther, E., Althausen, A., 1949. The Constituents of Essential Oils. In: Günther, E., (Editor), D. van Nostrand Co., Inc., The Essential Oils, Vol. II. New York.
8. Hodgson, E., Levi, P.E., 1994. Metabolism of toxicants: Phase I reactions. In: Hodgson, E., Levi, P.E. (Eds.), Introduction to Biochemical Toxicology, 2nd edn. Appleton and Lange, Norwalk, Connecticut, pp. 75-112.
9. Ioannides, C., Parke, D.V., 1990. The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab. Rev. 22, 1-85.
10. Ishii, K., Maeda, K., Kamataki, T., Kato, R., 1986. Mutagenic activation of aflatoxin B1 by several forms of purified cytochrome P-450. Mut. Res. 174, 85-88.
11. Kauderer, B., Zamith, H., Paumgartten, F.J.R., Speit, G., 1991. Evaluation of the mutagenicity of β-myrcene in mammalian cells in vitro. Environ. Mol. Mutagen. 18, 28-34.
12. Leung, A.Y., 1980. Encyclopedia of Common Natural Ingredients in Food, Drugs and Cosmetics. John Wiley and Sons, New York.
13. Nebert, D.W., Jones, J.E., 1989. Regulation of mammalian cytochrome P1-450 (CYP1A1) gene. Int. J. Biochem. 21, 243-252,
14. Oliveira, A.C.A.X., Carneiro, M.R.G., Cruz, C.M., Cataldo, A., Fernandes, M. A., Schulz-Schalge, T., Paumgartten, F.J.R., 1993. Efeito do β-mirceno sobre a atividade de monooxigenases hepaticas em ratos. Proceedings of the VIIIth Annual Meeting of the Brazilian Federation of Societies for Experimental Biology (FESBE), Caxambu, M.G., Brazil, 25-28 August.
15. Opdyke, D.L.J., 1979. Fragrance raw materials monographs: citral. Food Chem. Toxicol. 17, 259-266.
16. Röscheisen, C., Zamith, H., Paumgartten, F.J.R., Speit, G., 1991. Influence of β-myrcene on sister-chromatid exchanges induced by mutagens in V79 and HTC cells. Mut. Res. 264, 43-49.
17. Scheline, R.R., 1978. Mammalian metabolism of plant xenobiotics. Academic Press Inc., London, New York, San Francisco.
18. Segel, I.H., 1976. Biochemical calculations. John Wiley and Sons Inc., New York, Chichester, Brisbane.
19. Sticher, O., 1977. Plant mono-, di- and sesquiterpenoids with pharmacological or therapeutical activity. In: Wagner, H., Wolff, P. (Eds.), New Natural Products and Plant Drugs with Pharmaceutical, Biological or Therapeutical Activity. Springer-Verlag, Berlin, Heidelberg, New York, pp. 137-176.
20. Vinitketkumnuen, U., Puatanachokchai, R., Kongtawelert, P., Lertprasertsuke, N., Matsushima, T., 1994. Antimutagenicity of lemon grass (Cymbopogon citratus Stapf) to various known mutagens in salmonella mutation assay. Mut. Res. 341, 71-75.
21. Yoshizawa, H., Uchimaru, R., Kamataki, T., Kato, R., Ueno, Y., 1982. Metabolism and activation of aflatoxin B1 by reconstituted cytochrome P-450 system of rat liver. Cancer Res. 42, 1120-1124.