Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition

British Journal of Pharmacology

Volumn 163, Issue 2, 2011, Pages 330-345

  Liao, H T ^a   Lee, H J ^b   Ho, Y C ^a   Chiou, L C ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

2 arachidonoylglycerol; capsaicin; CB 1 cannabinoid receptors; endocannabinoids; metabotropic glutamate receptors; pain; periaqueductal gray; transient receptor potential vanilloid type 1 channels

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 4 AMINOBUTYRIC ACID; 4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; CANNABINOID 1 RECEPTOR; CAPSAICIN; ENDOCANNABINOID; GLUTAMIC ACID; LIPOPROTEIN LIPASE; METABOTROPIC RECEPTOR; VANILLOID RECEPTOR 1;

4 AMINOBUTYRIC ACID RELEASE; AMINO ACID TRANSPORT; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; EXCITATORY POSTSYNAPTIC POTENTIAL; GABAERGIC TRANSMISSION; HOT PLATE TEST; IN VITRO STUDY; IN VIVO STUDY; INHIBITORY POSTSYNAPTIC POTENTIAL; INTRACELLULAR RECORDING; MALE; MINIATURE ENDPLATE POTENTIAL; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE FUNCTION; NEUROPHYSIOLOGY; NONHUMAN; PATCH CLAMP; PERIAQUEDUCTAL GRAY MATTER; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN INDUCTION; RAT; RETROGRADE DISINHIBITION; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

ANALGESICS; ANIMALS; ARACHIDONIC ACIDS; CAPSAICIN; CELL MEMBRANE; EXCITATORY POSTSYNAPTIC POTENTIALS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GLYCERIDES; INHIBITORY POSTSYNAPTIC POTENTIALS; LIPOPROTEIN LIPASE; NEURONS; PAIN MEASUREMENT; PATCH-CLAMP TECHNIQUES; PERIAQUEDUCTAL GRAY; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TRPV CATION CHANNELS;

EID: 79954511348     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01214.x     Document Type: Article

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