Interactions between CB 1 receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons

British Journal of Pharmacology

Volumn 155, Issue 2, 2008, Pages 253-264

  Kim, S R ^a,b   Bok, E ^a   Chung, Y C ^a   Chung, E S ^a   Jin, B K ^a,c  

^a Ajou University School of Medicine   (South Korea)

^b Columbia University ^*  (United States)

^c Kyung Hee University   (South Korea)

Author keywords

12 hydroperoxyeicosatetraenoic acid; Cannabinoid type 1 receptor; COX 2; Transient receptor potential vanilloid 1

Indexed keywords

12 HYDROPEROXYICOSATETRAENOIC ACID; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ARACHIDONIC ACID DERIVATIVE; BAICALEIN; CANNABINOID 1 RECEPTOR; DEXANABINOL; HYDROXYICOSATETRAENOIC ACID; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; FEMALE; MESENCEPHALON; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; SUBSTANTIA NIGRA;

ANIMALS; CALCIUM; CELL DEATH; CELLS, CULTURED; CYCLOOXYGENASE 2 INHIBITORS; DOPAMINE; LEUKOTRIENES; MESENCEPHALON; NEURONS; NEUROTOXICITY SYNDROMES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; TRPV CATION CHANNELS;

EID: 51349150614     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.246     Document Type: Article

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