1-Benzyl-N-[3-[spiroisobenzofuran-1(3H),4′-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (Compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices

European Journal of Pharmacology

Volumn 606, Issue 1-3, 2009, Pages 84-89

  Liao, Yan Yu ^a   Trapella, Claudio ^b   Chiou, Lih Chu ^a,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b UNIVERSITY OF FERRARA   (Italy)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

1 Benzyl N 3 spiroisobenzofuran 1(3H),4 piperidin 1 yl propyl pyrrolidine 2 carboxamide; D Ala2, N Me Phe4, Gly5 ol enkephalin; Compound 24; Nociceptin; Orphanin FQ; Periaqueductal gray; Potassium channels

Indexed keywords

1 BENZYL N [3 [SPIROISOBENZOFURAN 1(3H) 4' PIPERIDIN 1 YL]PROPYL]PYRROLIDINE 2 CARBOXAMIDE; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; NOCICEPTIN RECEPTOR; OPIATE; OPIATE ANTAGONIST; OPIATE RECEPTOR; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; NONHUMAN; PAIN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMALS; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; NEURONS; OPIOID PEPTIDES; PERIAQUEDUCTAL GRAY; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, WISTAR; RECEPTORS, OPIOID; SPIRO COMPOUNDS;

EID: 60949108485     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.01.036     Document Type: Article

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