Expression of the Sonic hedgehog pathway in squamous cell carcinoma of the skin and the mucosa of the head and neck

Head and Neck

Volumn 33, Issue 2, 2011, Pages 244-250

  Schneider, Sven ^a   Thurnher, Dietmar ^a   Kloimstein, Philipp ^a   Leitner, Verena ^b   Petzelbauer, Peter ^b   Pammer, Johannes ^a   Brunner, Markus ^a   Erovic, Boban M ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Universitatsklinik fur Dermatologie   (Austria)

Author keywords

head and neck; skin; Sonic hedgehog; squamous cell carcinoma; tissue microarray

Indexed keywords

SONIC HEDGEHOG PROTEIN;

ADULT; AGED; ARTICLE; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SKIN CARCINOGENESIS; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; TISSUE MICROARRAY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MIDDLE AGED; MUTATION; NUCLEAR PROTEINS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTEIN ARRAY ANALYSIS; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 78751512615     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.21437     Document Type: Article

References (33)

1. Ingham PW, McMahon AP,. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15: 3059-3087.
2. Lum L, Beachy PA,. The hedgehog response network: sensors, switches, and routers. Science 2004; 304: 1755-1759.
3. Beachy PA, Karhadkar SS, Berman DM,. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004; 432: 324-331.
4. Zhao Y, Tong C, Jiang J,. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 2007; 450: 252-259.
5. Altaba Ari, Palma V, Dahamane N,. Hedgehog-Gli signaling and the growth of the brain. Nat Neurosci 2002; 3: 24-33.
6. Matise P, Joyner AL,. Gli genes in development and cancer. Oncogene 1999; 18: 7852-7859.
7. Daya-Grosjean L, Couve-Privat S,. Sonic Hedgehog signaling in basal cell carcinomas. Cancer Lett 2005; 225: 181-192.
8. Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002; 297: 1559-1561.
9. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB,. Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003; 422: 313-317.
10. Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumors. Nature 2003; 425: 846-851.
11. Beachy PA, Karhadkar SS, Berman DM,. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004; 432: 324-331.
12. Li X, Deng W, Nail C, et al. Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Oncogene 2006; 99: 609-621.
13. Lee SW, Moskowitz MA, Sims JR,. Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Int J Mol Med 2007; 99: 445-451.
14. Adolphe C, Hetherington R, Ellis T, Wainwright B,. Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res 2006; 99: 2081-2088.
15. Athar M, Li C, Tang X, et al. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res 2004; 99: 7545-7552.
16. Johnson TM, Rowe DE, Nelson BR, Swanson NA,. Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol 1992; 26: 467-484.
17. Rowe DE, Carroll RJ, Day CL,. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. J Am Acad Dermatol 1992; 26: 976-990.
18. Boukhalil P, Debek A,. Squamous-cell carcinoma with pericardial metastases. N Engl J Med 2006; 355: e24.
19. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ,. Cancer statistics, 2007. CA Cancer J Clin 2007; 57: 43-66.
20. Dahmane N, Lee J, Robins P, Heller P, Ruiz i Altaba A,. Activation of the transcription factor Gli1 and hedgehog signalling pathway in skin tumours. Nature 1997; 389: 876-881.
21. Altaba Ari, Sanchez P, Dahmane N,. Gli and hedgehog in cancer; tumours, embryos and stem cells. Nat Rev Cancer 2002; 2: 361-372.
22. Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 2004; 64: 6071-6074.
23. Wang LH, Choi YL, Hua XY, et al. Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions. Mod Pathol 2006; 19: 675-683.
24. Feng Y, Shiozawa T, Miyamoto T, et al. Overexpression of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells. Clin Cancer Res 2007; 13: 1389-1398.
25. Xuan YH, Jung HS, Choi YL, et al. Enhanced expression of hedgehog signaling molecules in squamous cell carcinoma of uterine cervix and its precursor lesions. Mod Pathol 2006; 19: 1139-1147.
26. Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003; 425: 851-856.
27. Qualtrough D, Buda A, Gaffield W, Williams AC, Paraskeva C,. Hedgehog signaling in colorectal tumor cells: induction of apoptosis with cyclopamine treatment. Int J Cancer 2004; 110: 831-837.
28. Koike C, Mizutani T, Ito T, et al. Introduction of wild-type patched gene suppresses the oncogenic potential human squamous cell carcinoma cell lines including A431. Oncogene 2002; 21: 2670-2678.
29. Hishimaki H, Kasai K, Kozaki K, et al. A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line. Biochem Biophys Res Commun 2004; 314: 313-320.
30. Miyazaki K, Saika S, Yamanaka O, Okada Y, Ohnishi Y,. Treatment of eyelid epithelial neoplasm by targeting sonic hedgehog signaling: an experimental study. Jpn J Ophthalmol 2006; 50: 305-311.
31. Mimeault M, Moore E, Moniaux N, et al. Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells. Int J Cancer 2006; 118: 1022-1031.
32. Williams JA, Guicherit OM, Zaharian BI, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A 2003; 100: 4616-4621.
33. Sims-Mourtada J, Izzo JG, Ajani J, Chao KS,. Sonic hedgehog promotes multiple drug resistance by regulation of drug transport. Oncogene 2007; 26: 5674-5679.