Hepatic glucokinase activity is the primary defect in alloxan-induced diabetes of mice

Biomedicine and Pharmacotherapy

Volumn 63, Issue 3, 2009, Pages 180-186

  Zhang, Xuemei ^a   Liang, Wenbo ^a   Mao, Yiqing ^b   Li, Hui ^b   Yang, Yang ^b   Tan, Huanran ^b  

^a DALIAN UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Alloxan; Alloxan induced diabetes; Diabetes mellitus; Glucokinase

Indexed keywords

ALLOXAN; GLUCOKINASE; GLUCOSE; LIVER ENZYME;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HYPERGLYCEMIA; HYPOINSULINEMIA; IMMUNOREACTIVITY; INSULIN RELEASE; LIVER; MALE; MOUSE; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSOR;

ALLOXAN; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOKINASE; INSULIN; LIVER; MALE; MICE;

EID: 61349185722     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2007.07.006     Document Type: Article

References (25)

1. J̈orns A., Tiedge M., Lenzen S., and Munday R. Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro. Free Radic Biol Med 26 (1999) 1300-1304
2. Rahimi R., Nikfar S., Larijani B., and Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother 59 (2005) 365-373
3. Tiedge M., Richter T., and Lenzen S. Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase. Arch Biochem Biophys 375 (2000) 251-260
4. Bloch K.O., Zemel R., Bloch O.V., Grief H., and Vardi P. Streptozotocin and alloxan-based selection improves toxin resistance of insulin producing RINm cells. Int J Exp Diabetes Res 1 (2000) 211-219
5. Gai W., Schott-Ohly P., Schulte imWalde S., and Gleichmann H. Differential target molecules for toxicity induced by streptozotocin and alloxan in pancreatic islets of mice in vitro. Exp Clin Endocrinol Diabetes 112 (2004) 29-37
6. Schulte imWalde S., Dohle C., Schott-Ohly P., and Gleichmann H. Molecular target structures in alloxan-induced diabetes in mice. Life Sci 71 (2002) 1681-1694
7. Trinder P. Determination of glucose in blood using oxidase with an alternative oxygen acceptor. Ann Clin Biochem 6 (1969) 24-30
8. Fales F.W. The assimilation and degradation of carbohydrates by yeast cells. J Biol Chem 193 (1951) 113-124
9. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
10. Massa L., Baltrusch S., Okar D.A., Lange A.J., Lenzen S., and Tiedge M. Interaction of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells. Diabetes 53 (2004) 1020-1029
11. Rencurel F., Munoz-Alonso M.J., Girard J., and Leturque A. An unusual high-Km hexokinase is expressed in the mhAT3F hepatoma cell line. J Biol Chem 273 (1998) 26187-26193
12. Méndez J.D., and Hernández R.D.H. l-Arginine and polyamine administration protect b-cells against alloxan diabetogenic effect in Sprague-Dawley rats. Biomed Pharmacother 59 (2005) 283-289
13. Zhang Y., Xiao M., Niu G., and Tan H. Mechanisms of oleic acid deterioration in insulin secretion: role in the pathogenesis of type 2 diabetes. Life Sci 77 (2005) 2071-2081
14. Soto C., Del Razo L.M., and Neri L. Alloxan decreases intracellular potassium content of the isolated frog skin epithelium. Comp Biochem Physiol C Toxicol Pharmacol 130 (2001) 19-27
15. Velho G., and Froguel P. Maturity-onset diabetes of the young (MODY), MODY genes and non-insulin-dependent diabetes mellitus. Diabetes Metab 23 (2002) 34-37
16. Janjic D., Maechler P., Sekine N., Bartley C., Annen A.-S., and Wollheim C.B. Free radical modulation of insulin release in INS-1cells exposed to alloxan. Biochem Pharmacol 57 (1999) 639-648
17. Murata M., Imada M., Inoue S., and Kawanishi S. Metal-mediated DNA damage induced by diabetogenic alloxan in the presence of NADH. Free Radic Biol Med 25 (1998) 586-595
18. Tappy L., Dussoix P., Iynedjian P., Henry S., Schneiter P., Zahnd G., et al. Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene. Diabetes 46 (1997) 204-208
19. Wang H., and Iynedjian P.B. Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase. Proc Natl Acad Sci U S A 94 (1997) 4372-4377
20. Velho G., and Robert J.J. Maturity-onset diabetes of the young (MODY): genetic and clinical characteristics. Horm Res 57 (2002) 29-33
21. Fujimoto W.Y. The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus. Am J Med 108 (2000) 9S-14S
22. Goldstein B.J. Insulin resistance as the core defect in type 2 diabetes mellitus. Am J Cardiol 90 (2002) 3G-10G
23. Tan M.H., and Bonen A. Their roles in the pathogenesis and management of type II diabetes mellitus. Ann Acad Med Singapore 14 (1985) 360-363
24. Bollen M., Keppens S., and Stalmans W. Specific features of glycogen metabolism in the liver. Biochem J 336 (1998) 19-31
25. Harbeck M.C., Louie D.C., Howland J., Wolf B.A., and Rothenberg P.L. Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells. Diabetes 45 (1996) 711-717