메뉴 건너뛰기




Volumn 45, Issue 4, 2010, Pages 320-331

Saponins from Panax japonicus protect against alcohol-induced hepatic injury in mice by up-regulating the expression of GPX3, SOD1 and SOD3

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; EXTRACELLULAR SUPEROXIDE DISMUTASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 3; MALONALDEHYDE; MESSENGER RNA; PANAX JAPONICUS EXTRACT; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SAPONIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; COPPER ZINC SUPEROXIDE DISMUTASE; FREE RADICAL; GPX3 PROTEIN, MOUSE; HERBACEOUS AGENT; SCAVENGER; SOD3 PROTEIN, MOUSE;

EID: 77954273711     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agq034     Document Type: Article
Times cited : (63)

References (31)
  • 1
    • 39749090649 scopus 로고    scopus 로고
    • Oxidative mechanisms in the pathogenesis of alcoholic liver disease
    • Albano E. (2008) Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 29:9-16.
    • (2008) Mol Aspects Med , vol.29 , pp. 9-16
    • Albano, E.1
  • 2
    • 0032847556 scopus 로고    scopus 로고
    • Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III
    • Bailey SM, Pietsch EC, Cunningham CC. (1999) Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III. Free Radic Biol Med 27:891-900.
    • (1999) Free Radic Biol Med , vol.27 , pp. 891-900
    • Bailey, S.M.1    Pietsch, E.C.2    Cunningham, C.C.3
  • 3
    • 0001047585 scopus 로고    scopus 로고
    • Reactive oxygen species: oxidative damage pathogenesis
    • Bandyopadhyay U, Das D, Banerjee RK. (1999) Reactive oxygen species: oxidative damage pathogenesis. Curr Sci 1999:658-65.
    • (1999) Curr Sci , vol.1999 , pp. 658-665
    • Bandyopadhyay, U.1    Das, D.2    Banerjee, R.K.3
  • 4
    • 0002889135 scopus 로고    scopus 로고
    • Cellular sources and steady-state levels of reactive oxygen species
    • Biadasz-Clerch L, Massaro DJ (eds). New York: Dekker
    • Boveris A, Cadenas E. (1997) Cellular sources and steady-state levels of reactive oxygen species. In Biadasz-Clerch L, Massaro DJ (eds). Oxygen, gene expression, and cellular function. New York: Dekker. 1-25.
    • (1997) Oxygen, gene expression, and cellular function , pp. 1-25
    • Boveris, A.1    Cadenas, E.2
  • 5
    • 4644310292 scopus 로고
    • Biochemistry of oxygen toxicity
    • Cadenas E. (1993) Biochemistry of oxygen toxicity. Annu Rev Biochem 58:34-40.
    • (1993) Annu Rev Biochem , vol.58 , pp. 34-40
    • Cadenas, E.1
  • 6
    • 0035894083 scopus 로고    scopus 로고
    • Introduction-serial review: alcohol, oxidative stress and cell injury
    • Cederbaum AI. (2001) Introduction-serial review: alcohol, oxidative stress and cell injury. Free Radic Biol Med 31:1524-30.
    • (2001) Free Radic Biol Med , vol.31 , pp. 1524-1530
    • Cederbaum, A.I.1
  • 7
    • 0038825258 scopus 로고    scopus 로고
    • Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress
    • Chen XC, Zhu YG, Zhu LA et al. (2003) Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur J Pharmacol 473:1-7.
    • (2003) Eur J Pharmacol , vol.473 , pp. 1-7
    • Chen, X.C.1    Zhu, Y.G.2    Zhu, L.A.3
  • 8
    • 33749597707 scopus 로고    scopus 로고
    • Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease
    • Day CP. (2006) Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int 26: 1021-8.
    • (2006) Liver Int , vol.26 , pp. 1021-1028
    • Day, C.P.1
  • 9
    • 0036017170 scopus 로고    scopus 로고
    • Liver disease in alcohol abusers: clinical perspective
    • Diehl AM. (2002) Liver disease in alcohol abusers: clinical perspective. Alcohol 27:7-11.
    • (2002) Alcohol , vol.27 , pp. 7-11
    • Diehl, A.M.1
  • 10
    • 39649122125 scopus 로고    scopus 로고
    • Structural identification of ginseng polysaccharides and testing of their antioxidant activities
    • Luo DH, Fang BS. (2008) Structural identification of ginseng polysaccharides and testing of their antioxidant activities. Carbohydr Polym 72:376-81.
    • (2008) Carbohydr Polym , vol.72 , pp. 376-381
    • Luo, D.H.1    Fang, B.S.2
  • 11
    • 15944426424 scopus 로고    scopus 로고
    • Antioxidant activities of cultivated and wild Korean ginseng leaves
    • Jung CH, Seog HM, Chio IW et al. (2005) Antioxidant activities of cultivated and wild Korean ginseng leaves. Food Chem 92:535-40.
    • (2005) Food Chem , vol.92 , pp. 535-540
    • Jung, C.H.1    Seog, H.M.2    Chio, I.W.3
  • 12
    • 59549100664 scopus 로고    scopus 로고
    • Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanolinduced hepatotoxicity in mice
    • Khanal T, Choi JH, Hwang YP et al. (2009) Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanolinduced hepatotoxicity in mice. Food Chem Toxicol 47:530-5.
    • (2009) Food Chem Toxicol , vol.47 , pp. 530-535
    • Khanal, T.1    Choi, J.H.2    Hwang, Y.P.3
  • 13
    • 34247383190 scopus 로고    scopus 로고
    • Protective effect of steamed American ginseng (Panax quinquefolius L) on V79-4 cells induced by oxidative stress
    • Kim KT, Yoo KM, Lee JW et al. (2007) Protective effect of steamed American ginseng (Panax quinquefolius L.) on V79-4 cells induced by oxidative stress. J Ethnopharmacol 111:443-50.
    • (2007) J Ethnopharmacol , vol.111 , pp. 443-450
    • Kim, K.T.1    Yoo, K.M.2    Lee, J.W.3
  • 14
    • 0033994838 scopus 로고    scopus 로고
    • Antioxidant properties of a North American ginseng extract
    • Kitts DD, Wijewickreme AN, Hu C. (2000) Antioxidant properties of a North American ginseng extract. Mol Cell Biochem 203: 1-10.
    • (2000) Mol Cell Biochem , vol.203 , pp. 1-10
    • Kitts, D.D.1    Wijewickreme, A.N.2    Hu, C.3
  • 15
    • 0035841944 scopus 로고    scopus 로고
    • Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice
    • Lee KJ, You HJ, Park SJ et al. (2001) Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice. Cancer Lett 174:73-81.
    • (2001) Cancer Lett , vol.174 , pp. 73-81
    • Lee, K.J.1    You, H.J.2    Park, S.J.3
  • 16
    • 0842346030 scopus 로고    scopus 로고
    • Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity
    • Lee KJ, Choi CY, Chung YC et al. (2004) Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity. Toxicol Lett 147:271-82.
    • (2004) Toxicol Lett , vol.147 , pp. 271-282
    • Lee, K.J.1    Choi, C.Y.2    Chung, Y.C.3
  • 17
    • 40849119812 scopus 로고    scopus 로고
    • Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice
    • Lee KJ, Choi JH, Kim HG et al. (2008) Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice. Food Chem Toxicol 46:1778-85.
    • (2008) Food Chem Toxicol , vol.46 , pp. 1778-1785
    • Lee, K.J.1    Choi, J.H.2    Kim, H.G.3
  • 18
    • 0032782069 scopus 로고    scopus 로고
    • Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin
    • Lee SJ, Sung JH, Lee SJ et al. (1999) Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Lett 144:39-43.
    • (1999) Cancer Lett , vol.144 , pp. 39-43
    • Lee, S.J.1    Sung, J.H.2    Lee, S.J.3
  • 19
    • 24044443225 scopus 로고    scopus 로고
    • Radioprotective potential of ginseng
    • Lee TK, Johnke RM, Allison RR et al. (2005) Radioprotective potential of ginseng. Mutagenesis 20:237-43.
    • (2005) Mutagenesis , vol.20 , pp. 237-243
    • Lee, T.K.1    Johnke, R.M.2    Allison, R.R.3
  • 20
    • 38049062023 scopus 로고    scopus 로고
    • Protective effect of Panax japonicus on ethanol-induced gastric lesion
    • Li YG, Xu G, Chen S et al. (2007) Protective effect of Panax japonicus on ethanol-induced gastric lesion. Chin J Chin Mater Med 32:2282-5.
    • (2007) Chin J Chin Mater Med , vol.32 , pp. 2282-2285
    • Li, Y.G.1    Xu, G.2    Chen, S.3
  • 21
    • 0031864164 scopus 로고    scopus 로고
    • Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
    • Parkes TL, Elia AJ, Dickinson D et al. (1998) Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet 19:171-4.
    • (1998) Nat Genet , vol.19 , pp. 171-174
    • Parkes, T.L.1    Elia, A.J.2    Dickinson, D.3
  • 22
    • 69049093665 scopus 로고    scopus 로고
    • Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis
    • Peng XD, Dai LL, Huang CQ et al. (2009) Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. Biochem Biophys Res Commun 388:31-4.
    • (2009) Biochem Biophys Res Commun , vol.388 , pp. 31-34
    • Peng, X.D.1    Dai, L.L.2    Huang, C.Q.3
  • 23
    • 29244460388 scopus 로고    scopus 로고
    • Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats
    • Saravanan R, Viswanathan P, Pugalendi KV. (2006) Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. Life Sci 78:713-8.
    • (2006) Life Sci , vol.78 , pp. 713-718
    • Saravanan, R.1    Viswanathan, P.2    Pugalendi, K.V.3
  • 24
    • 0042977425 scopus 로고    scopus 로고
    • Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury
    • Senthil KR, Ponmozhi M, Viswanathan P et al. (2003) Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury. J Nutr Biochem 14:452-8.
    • (2003) J Nutr Biochem , vol.14 , pp. 452-458
    • Senthil, K.R.1    Ponmozhi, M.2    Viswanathan, P.3
  • 25
    • 0028947141 scopus 로고
    • Antiperoxide effects of S-allyl cystein sulphoxide isolated from Allium sativum Linn and gugulipid in cholesterol diet fed rats
    • Sheela CG, Angusti KT. (1995) Antiperoxide effects of S-allyl cystein sulphoxide isolated from Allium sativum Linn and gugulipid in cholesterol diet fed rats. Indian J Exp Biol 33: 337-41.
    • (1995) Indian J Exp Biol , vol.33 , pp. 337-341
    • Sheela, C.G.1    Angusti, K.T.2
  • 26
    • 0033011578 scopus 로고    scopus 로고
    • Effects of administration of the standardized Panax ginseng extract G115 on hepatic antioxidant function after exhaustive exercise
    • Voces J, Alvarez AI, Vila L et al. (1999) Effects of administration of the standardized Panax ginseng extract G115 on hepatic antioxidant function after exhaustive exercise. Comp Biochem Physiol C 123:175-84.
    • (1999) Comp Biochem Physiol C , vol.123 , pp. 175-184
    • Voces, J.1    Alvarez, A.I.2    Vila, L.3
  • 27
    • 84923510489 scopus 로고    scopus 로고
    • Extraction technology for the total saponin of Panax japonicus
    • Xiang DS, Zhai K. (2008) Extraction technology for the total saponin of Panax japonicus. Chin J Chin Mater Med 16:2053-5056.
    • (2008) Chin J Chin Mater Med , vol.16 , pp. 2053-5056
    • Xiang, D.S.1    Zhai, K.2
  • 28
    • 27744515736 scopus 로고    scopus 로고
    • Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen peroxide-induced cytotoxity of human umbilical cord vein endothelial cells in vitro
    • Xin XJ, Zhong J, Wei DZ et al. (2005) Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen peroxide-induced cytotoxity of human umbilical cord vein endothelial cells in vitro. Process Biochem 40:3202-5.
    • (2005) Process Biochem , vol.40 , pp. 3202-3205
    • Xin, X.J.1    Zhong, J.2    Wei, D.Z.3
  • 29
    • 0023101198 scopus 로고
    • Anti-ulcer action of Panax japonicus rhizome
    • Yamahara J, Kubomura Y, Miki K et al. (1987) Anti-ulcer action of Panax japonicus rhizome. J. Ethnopharmacol 19:95-101.
    • (1987) J. Ethnopharmacol , vol.19 , pp. 95-101
    • Yamahara, J.1    Kubomura, Y.2    Miki, K.3
  • 31
    • 33646570859 scopus 로고    scopus 로고
    • Antioxidant activities of Salvia miltiorrhiza and Panax notoginseng
    • Zhao GR, Xiang ZJ, Ye TX et al. (2006) Antioxidant activities of Salvia miltiorrhiza and Panax notoginseng. Food Chem 99:767-74.
    • (2006) Food Chem , vol.99 , pp. 767-774
    • Zhao, G.R.1    Xiang, Z.J.2    Ye, T.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.