Nifurtimox induces apoptosis of neuroblastoma cells in vitro and in vivo

Journal of Pediatric Hematology/Oncology

Volumn 31, Issue 3, 2009, Pages 187-193

  Saulnier Sholler, Giselle L ^a,b,d   Brard, Laurent ^c   Straub, Jennifer A ^a   Dorf, Lee ^b   Illeyne, Sharon ^b   Koto, Karen ^b   Kalkunte, Satyan ^c   Bosenberg, Marcus ^a,b   Ashikaga, Taka ^b   Nishi, Rae ^a,b  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c BROWN UNIVERSITY   (United States)

^d FLETCHER ALLEN HEALTH CARE   (United States)

Author keywords

Apoptosis; Catecholamine; Neuroblastoma; Nitrofuran; Reactive oxygen species

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CASPASE 3; METIROSINE; NIFURTIMOX; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; CATECHOLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CATECHOLAMINE NERVE CELL; CELL DEATH; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CHILD; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROBLASTOMA; NEUROBLASTOMA CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; WESTERN BLOTTING; ANIMAL; DNA FRAGMENTATION; DRUG EFFECT; DRUG SCREENING; METABOLISM; NERVE CELL; NUDE MOUSE; PHOSPHORYLATION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CATECHOLAMINES; CELL LINE, TUMOR; DNA FRAGMENTATION; FEMALE; HUMANS; IN SITU NICK-END LABELING; MICE; MICE, NUDE; NEUROBLASTOMA; NEURONS; NIFURTIMOX; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 65449126667     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e3181984d91     Document Type: Article

References (20)

1. Brodeur GM, Pritchard J, Berthold F, et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol. 1993;11:1466-1477.
2. Brodeur GM, Maris JM, Yamashiro DJ, et al. Biology and genetics of human neuroblastomas. J Pediatr Hematol Oncol. 1997;19:93-101.
3. Ho R, Eggert A, Hishiki T, et al. Resistance to chemotherapy mediated by TrkB in neuroblastomas. Cancer Res. 2002;62: 6462-6466.
4. Saulnier Sholler GL, Kalkunte S, Greenlaw C, et al. Antitumor activity of nifurtimox observed in a patient with neuroblastoma. J Pediatr Hematol Oncol. 2006;28:693-695.
5. Docampo R, Stoppani AO. Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi. Arch Biochem Biophys. 1979;197:317-321.
6. Nishi R. Autonomic and sensory neuron cultures. Methods Cell Biol. 1996;51:249-263.
7. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312-1316.
8. Puppo M, Pastorino S, Melillo G, et al. Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulation. Clin Cancer Res. 2004;10:8704-8719.
9. Jaboin J, Kim CJ, Kaplan DR, et al. Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinosi-tol 3′-kinase pathway. Cancer Res. 2002;62:6756-6763.
10. Spector S, Sjoerdsma A, Udenfriend S. Blockade of endogenous norepinephrine synthesis by alphamethyl-tyrosine, and inhibitor of tyrosine hydroxylase. J Pharmacol Ther. 1965;147: 86-95.
11. Rohrer H, Ernsberger U. The differentiation of the neuro-transmitter phenotypes in chick sympathetic neurons. Adv Pharmacol. 1998;42:891-895.
12. Nishi R, Berg DK. Survival and development of ciliary ganglion neurons grown alone in cell culture. Nature. 1979; 277:232-234.
13. Solari A, Ortiz S, Soto A, et al. Treatment of Trypanosoma cruzi-infected children with nifurtimox: a 3 year follow-up by PCR. J Antimicrob Chemother. 2001;48:515-519.
14. Dubin M, Grinblat L, Fernandez Villamil SH, et al. Nitrofuran inhibition of microsomal lipid peroxidation. FEBS Lett. 1987;220:197-200.
15. Rao DN, Mason RP. Generation of nitro radical anions of some 5-nitrofurans, 2- and 5-nitroimidazoles by norepinephrine, dopamine, and serotonin. A possible mechanism for neuro-toxicity caused by nitroheterocyclic drugs. J Biol Chem. 1987; 262:11731-11736.
16. Paulino-Blumenfeld M, Hansz M, Hikichi N, et al. Electronic properties and free radical production by nitrofuran compounds. Free Radical Res Comm. 1992;16:207-215.
17. Letelier ME, Izquierdo P, Godoy L, et al. Liver microsomal biotransformation of nitro-aryl drugs: mechanism for potential oxidative stress induction. J Appl Toxicol. 2004;24:519-525.
18. Moreno SN, Mason RP, Docampo R. Reduction of nifurtimox and nitrofurantoin to free radical metabolites by rat liver mitochondria. Evidence of an outer membrane-located nitroreductase. J Biol Chem. 1984;259:6298-6305.
19. Middlemas DS, Kihl BK, Zhou J, et al. Brain-derived neurotrophic factor promotes survival and chemoprotection of human neuroblastoma cells. J Biol Chem. 1999;274: 16451-16460.
20. Middlemas DS, Kihl BK, Moody NM. Brain derived neurotrophic factor protects human neuroblastoma cells from DNA damaging agents. J Neurooncol. 1999;45:27-36.