Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: Inhibition of the plasmodial chaperone PfHsp70-1

Biological Chemistry

Volumn 392, Issue 5, 2011, Pages 431-438

  Cockburn, Ingrid L ^a   Pesce, Eva Rachele ^a   Pryzborski, Jude M ^b   Davies Coleman, Michael T ^a   Clark, Peter G K ^c   Keyzers, Robert A ^a,c   Stephens, Linda L ^a   Blatch, Gregory L ^a  

^a RHODES UNIVERSITY   (South Africa)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

Author keywords

heat shock proteins; malaria; malonganenones; molecular chaperones; naphthoquinones; Plasmodium falciparum

Indexed keywords

ALIL LAUSONA; ALKALOID; ALPHA LAPACHONA; ANTIMALARIAL AGENT; BROMO BETA LAPACHONA; CHAPERONE; HEAT SHOCK PROTEIN 70; HYDROXY BETA LAPACHONA; LAPACHOL; MALONGANENONE A; MALONGANENONE B; MALONGANENONE C; NAPHTHOQUINONE; NOR BETA LAPACHONA; PROBIOTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ERYTHROCYTE; GROWTH INHIBITION; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN AGGREGATION; SCREENING TEST;

ALKALOIDS; ANTIMALARIALS; HSP72 HEAT-SHOCK PROTEINS; INHIBITORY CONCENTRATION 50; NAPHTHOQUINONES; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 79953855334     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2011.040     Document Type: Article

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