AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells

Diabetologia

Volumn 54, Issue 1, 2011, Pages 125-134

  Leclerc, I ^a   Sun, G ^a   Morris, C ^a   Fernandez Millan, E ^a,b   Nyirenda, M ^a   Rutter, G A ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

AMP activated protein kinase; Glucagon secretion; Pancreatic alpha cells; Pancreatic islets of Langerhans

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLUCAGON RELEASE; HOMEOSTASIS; IMMUNOCYTOCHEMISTRY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RADIOIMMUNOASSAY; SIGNAL TRANSDUCTION;

ACETYLTRANSFERASES; ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL LINE; ENZYME ACTIVATION; FEMALE; GLUCAGON; GLUCAGON-SECRETING CELLS; GLUCOSE; HYPOGLYCEMIC AGENTS; IMMUNOHISTOCHEMISTRY; METFORMIN; MICE; PHENFORMIN; PHOSPHORYLATION; PYRONES; THIOPHENES;

EID: 79953801802     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1929-z     Document Type: Article

References (46)

1. Gelling RW, Du XQ, Dichmann DS et al (2003) Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci USA 100:1438-1443 (Pubitemid 36184020)
2. Gromada J, Franklin I, Wollheim CB (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 28:84-116 (Pubitemid 46220851)
3. Rutter GA (2009) Regulating glucagon secretion: somatostatin in the spotlight. Diabetes 58:299-301
4. Bailey SJ, Ravier MA, Rutter GA (2007) Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells. Diabetes 56:320-327
5. Ravier MA, Rutter GA (2005) Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. Diabetes 54:1789-1797 (Pubitemid 40770769)
6. Kahn BB, Alquier T, Carling D, Hardie DG (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1:15-25 (Pubitemid 43960587)
7. Towler MC, Hardie DG (2007) AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100:328-341
8. Hawley SA, Boudeau J, Reid JL et al (2003) Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/ beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2:28
9. Woods A, Johnstone SR, Dickerson K et al (2003) LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13:2004-2008 (Pubitemid 37425212)
10. 2+/calmodulin-dependent protein kinase kinase beta. Mol Cell Biol 26:5933-5945
11. Hardie DG, Carling D, Carlson M (1998) The AMP-activated/ SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67:821-855
12. Thelander M, Olsson T, Ronne H (2004) Snf1-related protein kinase 1 is needed for growth in a normal day-night light cycle. EMBO J 23:1900-1910 (Pubitemid 38649652) (Pubitemid 38649652)
13. Narbonne P, Roy R (2009) Caenorhabditis elegans Dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature 457:210-214
14. Zhou G, Myers R, Li Y et al (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174 (Pubitemid 32995375) (Pubitemid 32995375)
15. Han SM, Namkoong C, Jang PG et al (2005) Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats. Diabetologia 48:2170-2178 (Pubitemid 41416931) (Pubitemid 41416931)
16. Leclerc I, Kahn A, Doiron B (1998) The 5′ AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex. FEBS Lett 431:180-184
17. Alquier T, Kawashima J, Tsuji Y, Kahn BB (2007) Role of hypothalamic adenosine 5′-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia. Endocrinology 148:1367-1375
18. McCrimmon RJ, Fan X, Cheng H et al (2006) Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation. Diabetes 55:1755-1760 (Pubitemid 44324129) (Pubitemid 44324129)
19. Tsuboi T, da Silva XG, Leclerc I, Rutter GA (2003) 5′-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. J Biol Chem 278:52042-52051 (Pubitemid 38035789) (Pubitemid 38035789)
20. da Silva XG, Leclerc I, Varadi A, Tsuboi T, Moule SK, Rutter GA (2003) Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J 371:761-774 (Pubitemid 36578875) (Pubitemid 36578875)
21. Leclerc I, Woltersdorf WW, da Silva XG et al (2004) Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab 286:E1023-E1031 (Pubitemid 38668827) (Pubitemid 38668827)
22. Targonsky ED, Dai F, Koshkin V et al (2006) Alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Diabetologia 49:1587-1598 (Pubitemid 43848095) (Pubitemid 43848095)
23. Richards SK, Parton LE, Leclerc I, Rutter GA, Smith RM (2005) Over-expression of AMP-activated protein kinase impairs pancreatic beta-cell function in vivo. J Endocrinol 187:225-235 (Pubitemid 41685182) (Pubitemid 41685182)
24. Sun G, Tarasov AI, McGinty J et al (2010) Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia 53:924-936
25. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509-2514 (Pubitemid 28145972) (Pubitemid 28145972)
26. 2+ oscillations and insulin secretion in pancreatic islets. Biochem J 353:175-180
27. Woods A, Azzout-Marniche D, Foretz M et al (2000) Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol 20:6704-6711
28. Noordeen NA, Khera TK, Sun G et al (2009) Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells. Diabetes 59:153-160
29. + channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults. Diabetes 57:1595-1604
30. Hardie DG (2006) Neither LKB1 nor AMPK are the direct targets of metformin. Gastroenterology 131:973, author reply 974-975
31. Scott JW, van Denderen BJ, Jorgensen SB et al (2008) Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol 15:1220-1230
32. Cool B, Zinker B, Chiou W et al (2006) Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab 3:403-416 (Pubitemid 43811782) (Pubitemid 43811782)
33. Owen MR, Doran E, Halestrap AP (2000) Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348 (Pt 3):607-614 (Pubitemid 30410251) (Pubitemid 30410251)
34. + channels. J Physiol 528:509-520
35. Liu YJ, Vieira E, Gylfe E (2004) A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell. Cell Calcium 35:357-365 (Pubitemid 38351204) (Pubitemid 38351204)
36. Manning Fox JE, Gyulkhandanyan AV, Satin LS, Wheeler MB (2006) Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat. Endocrinology 147:4655-4663 (Pubitemid 44402171) (Pubitemid 44402171)
37. MacDonald PE, De Marinis YZ, Ramracheya R et al (2007) A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol 5:e143
38. Detimary P, Dejonghe S, Ling Z, Pipeleers D, Schuit F, Henquin JC (1998) The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets. J Biol Chem 273:33905-33908 (Pubitemid 29008852) (Pubitemid 29008852)
39. Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB (2003) Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 5:330-335 (Pubitemid 36432297) (Pubitemid 36432297)
40. Kennedy HJ, Pouli AE, Ainscow EK, Jouaville LS, Rizzuto R, Rutter GA (1999) Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria. J Biol Chem 274:13281-13291
41. Olsen HL, Theander S, Bokvist K, Buschard K, Wollheim CB, Gromada J (2005) Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology 146:4861-4870 (Pubitemid 41446624) (Pubitemid 41446624)
42. 2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem 280:29060-29066
43. Hawley SA, Pan DA, Mustard KJ et al (2005) Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2:9-19 (Pubitemid 43239821) (Pubitemid 43239821)
44. Woods A, Dickerson K, Heath R et al (2005) Ca2+/ calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2:21-33 (Pubitemid 43239822) (Pubitemid 43239822)
45. Lim A, Park SH, Sohn JW et al (2009) Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells. Diabetes 58:2813-2819
46. McDonald A, Fogarty S, Leclerc I, Hill EV, Hardie DG, Rutter GA (2010) Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/ Ser520 in glucose-stimulated insulin granule movement. Biochem Soc Trans 38:205-208