Gastric Tolerability and Prolonged Prostaglandin Inhibition in the Brain with a Nitric Oxide-Releasing Flurbiprofen Derivative, NCX-2216 [3-[4-(2-Fluoro-α-methyl-[1,1′-biphenyl]-4-acetyloxy) -3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester]

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 2, 2004, Pages 626-633

  Wallace, John L ^a,e   Muscará, Marcelo N ^b   De Nucci, Gilberto ^b   Zamuner, Stella ^a   Cirino, Giuseppe ^c   Del Soldato, Piero ^d   Ongini, Ennio ^d  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d Nicox Research Institute   (Italy)

^e Dept of Pharmacol and Therapeutics ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

[3 [4 [2 FLUORO ALPHA METHYL (1,1' BIPHENYL) 4 ACETYLOXY] 3 METHOXYPHENYL] 2 PROPENOIC ACID 4 NITROOXY BUTYL ESTER]; ACRYLIC ACID DERIVATIVE; AMYLOID BETA PROTEIN; ANTIOXIDANT; BIPHENYL DERIVATIVE; DRUG METABOLITE; FERULIC ACID; FLURBIPROFEN; NCX 2057; NCX 2216; NCX 2226; NITRIC OXIDE DONOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN INHIBITOR; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ENZYME REPRESSION; INFLAMMATORY DISEASE; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; RAT; STOMACH; STOMACH INJURY; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE;

ANIMALS; ANTIOXIDANTS; BRAIN; CYCLOOXYGENASE INHIBITORS; FLURBIPROFEN; MALE; MICE; NITRIC OXIDE; PROSTAGLANDIN ANTAGONISTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; RATS; RATS, WISTAR; STOMACH;

EID: 2142757264     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.063453     Document Type: Article

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