In vitro metabolism of (nitrooxy)butyl ester nitric oxide-releasing compounds: Comparison with glyceryl trinitrate

Journal of Pharmacology and Experimental Therapeutics

Volumn 317, Issue 2, 2006, Pages 752-761

  Govoni, Mirco ^a   Casagrande, Simona ^a   Maucci, Raffaella ^a   Chiroli, Valerio ^a   Tocchetti, Paola ^a  

^a Nicox Research Institute   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

(1,1' BIPHENYL) 4 ACETIC ACID 2 FLUORO ALPHA METHYL 4 HYDROXYBUTYL ESTER; (NITROOXY)BUTYL ALCOHOL; 3 (4 HYDROXY 3 METHOXYPHENYL) 2 PROPENOIC ACID 4 (NITROOXY)BUTYL ESTER; 3 (4 HYDROXY 3 METHOXYPHENYL) 2 PROPENOIC ACID 4 HYDROXYBUTYL ESTER; ACRYLIC ACID DERIVATIVE; ALCOHOL DERIVATIVE; CARBOXYL GROUP; DRUG METABOLITE; ESTER; ESTERASE INHIBITOR; FERULIC ACID; FLURBIPROFEN; FLURBIPROFEN 4 NITROXYBUTYL ESTER; GLUTATHIONE TRANSFERASE; GLYCERYL TRINITRATE; HCT 1027; INORGANIC COMPOUND; ISOENZYME; LIVER ENZYME; NCX 2057; NCX 2059; NITRATE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROGEN OXIDE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD; CELL COMPARTMENTALIZATION; CELL FRACTIONATION; CONTROLLED STUDY; DEOXYGENATION; DRUG ACTIVATION; DRUG BIOAVAILABILITY; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG STABILITY; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME REGULATION; ERYTHROCYTE; IN VITRO STUDY; LIVER; LIVER CYTOSOL; LIVER METABOLISM; LIVER MITOCHONDRION; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; SYSTEMIC CIRCULATION;

ANIMALS; BIOTRANSFORMATION; BUTANES; CYTOSOL; FLURBIPROFEN; LIVER; MALE; MITOCHONDRIA, LIVER; MOLECULAR STRUCTURE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRO COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33645867681     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.097469     Document Type: Article

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