Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells

European Journal of Medicinal Chemistry

Volumn 43, Issue 4, 2008, Pages 839-845

  Perjési, Pal ^a   Das, Umashankar ^b   De Clercq, Erik ^c   Balzarini, Jan ^c   Kawase, Masame ^d   Sakagami, Hiroshi ^e   Stables, James P ^f   Lorand, Tamas ^a   Rozmer, Zsuzsanna ^a   Dimmock, Jonathan R ^b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d MATSUYAMA UNIVERSITY   (Japan)

^e MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^f NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

, Unsaturated ketones; 3 Benzylidene 4 chromanones; Cytotoxicity; Molecular modelling; Murine toxicity

Indexed keywords

2 BENZYLIDENE 1 TETRALONE DERIVATIVE; 3 (2 BROMOBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (2 CHLOROBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (2 METHOXYBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (2,4 DIMETHOXYBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (3 BROMOBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (3 METHOXYBENZYLIDINE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (3 METHYLBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (4 BROMOBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (4 CHLOROBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (4 DIMETHYLAMINOBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (4 METHOXYBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 (4 METHYLBENZYLIDENE) 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE; 3 BENZYLIDENE 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE DERIVATIVE; 3 BENZYLIDENE 4 CHROMANONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA L 1210; MOLECULAR MODEL; MOUSE; NONHUMAN; T LYMPHOCYTE;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOPYRANS; CELL SURVIVAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HUMANS; INJECTIONS, INTRAPERITONEAL; LEUKEMIA L1210; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; NEURONS; STRUCTURE-ACTIVITY RELATIONSHIP; SURVIVAL RATE; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 41249096543     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.017     Document Type: Article

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