HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Zhu, Dan Ming ^a   Shi, Juan ^a   Liu, Shilian ^a   Liu, Yanxin ^a   Zheng, Dexian ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DEATH RECEPTOR 5 ANTIBODY; FLICE INHIBITORY PROTEIN; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RECEPTOR ANTIBODY; RECOMBINANT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND DECOY RECEPTOR 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR 3; UNCLASSIFIED DRUG; CASPASE; CFLAR PROTEIN, HUMAN; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR DECOY RECEPTOR;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LEVEL; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MACROPHAGE; MONOCYTE DERIVED MACROPHAGE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PSEUDOTYPING; VIRUS CELL INTERACTION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; MONOCYTE; PHOSPHORYLATION; PHYSIOLOGY; SOLUBILITY; VIROLOGY; VIRUS LATENCY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIBODIES, MONOCLONAL; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASES; DOWN-REGULATION; DRUG SYNERGISM; HEK293 CELLS; HIV-1; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGES; MONOCYTES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; SOLUBILITY; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR DECOY RECEPTORS; VIRUS LATENCY;

EID: 79953725744     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018291     Document Type: Article

References (45)

1. Carter CA, Ehrlich LS, (2008) Cell biology of HIV-1 infection of macrophages. Annu Rev Microbiol 62: 425-443.
2. Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, et al. (2007) Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood 109: 4272-4279.
3. Erdmann N, Tian C, Huang Y, Zhao J, Herek S, et al. (2009) In vitro glutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage. J Neurochem 109: 551-561.
4. Orenstein JM, Fox C, Wahl SM, (1997) Macrophages as a source of HIV during opportunistic infections. Science 276: 1857-1861.
5. Schnell G, Spudich S, Harrington P, Price RW, Swanstrom R, (2009) Compartmentalized human immunodeficiency virus type 1 originates from long-lived cells in some subjects with HIV-1-associated dementia. PLoS Pathog 5: e1000395.
6. Toro-Nieves DM, Rodriguez Y, Plaud M, Ciborowski P, Duan F, et al. (2009) Proteomic analyses of monocyte-derived macrophages infected with human immunodeficiency virus type 1 primary isolates from Hispanic women with and without cognitive impairment. J Neurovirol 15: 36-50.
7. Crowe SM, (1995) Role of macrophages in the pathogenesis of human immunodeficiency virus (HIV) infection. Aust N Z J Med 25: 777-783.
8. Douek DC, Roederer M, Koup RA, (2009) Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med 60: 471-484.
9. Gura T, (1997) How TRAIL kills cancer cells, but not normal cells. Science 277: 768.
10. Huang Y, Erdmann N, Peng H, Herek S, Davis JS, et al. (2006) TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation. J Immunol 177: 2304-2313.
11. Lum JJ, Pilon AA, Sanchez-Dardon J, Phenix BN, Kim JE, et al. (2001) Induction of cell death in human immunodeficiency virus-infected macrophages and resting memory CD4 T cells by TRAIL/Apo2l. J Virol 75: 11128-11136.
12. LeBlanc HN, Ashkenazi A, (2003) Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ 10: 66-75.
13. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, et al. (1997) The receptor for the cytotoxic ligand TRAIL. Science 276: 111-113.
14. Pan G, Ni J, Wei YF, Yu G, Gentz R, et al. (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277: 815-818.
15. Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, et al. (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277: 818-821.
16. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, et al. (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388: 190-195.
17. Mahalingam D, Szegezdi E, Keane M, Jong S, Samali A, (2009) TRAIL receptor signalling and modulation: Are we on the right TRAIL? Cancer Treat Rev 35: 280-288.
18. Deveraux QL, Takahashi R, Salvesen GS, Reed JC, (1997) X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388: 300-304.
19. Dharmapatni AA, Smith MD, Findlay DM, Holding CA, Evdokiou A, et al. (2009) Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium. Arthritis Res Ther 11: R13.
20. Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC, (1997) The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 16: 6914-6925.
21. Hinz S, Trauzold A, Boenicke L, Sandberg C, Beckmann S, et al. (2000) Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis. Oncogene 19: 5477-5486.
22. Fulda S, Meyer E, Debatin KM, (2002) Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. Oncogene 21: 2283-2294.
23. Guo Y, Chen C, Zheng Y, Zhang J, Tao X, et al. (2005) A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death. J Biol Chem 280: 41940-41952.
24. Ma H, Liu Y, Liu S, Kung HF, Sun X, et al. (2005) Recombinant adeno-associated virus-mediated TRAIL gene therapy suppresses liver metastatic tumors. Int J Cancer 116: 314-321.
25. Wei X, Decker JM, Liu H, Zhang Z, Arani RB, et al. (2002) Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob Agents Chemother 46: 1896-1905.
26. Biggs BA, Hewish M, Kent S, Hayes K, Crowe SM, (1995) HIV-1 infection of human macrophages impairs phagocytosis and killing of Toxoplasma gondii. J Immunol 154: 6132-6139.
27. Gendelman HE, Orenstein JM, Martin MA, Ferrua C, Mitra R, et al. (1988) Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med 167: 1428-1441.
28. Karacostas V, Nagashima K, Gonda MA, Moss B, (1989) Human immunodeficiency virus-like particles produced by a vaccinia virus expression vector. Proc Natl Acad Sci U S A 86: 8964-8967.
29. Tsang J, Chain BM, Miller RF, Webb BL, Barclay W, et al. (2009) HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation. AIDS 23: 2255-2263.
30. Chun TW, Carruth L, Finzi D, Shen X, DiGiuseppe JA, et al. (1997) Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387: 183-188.
31. Griffith TS, Wiley SR, Kubin MZ, Sedger LM, Maliszewski CR, et al. (1999) Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL. J Exp Med 189: 1343-1354.
32. Andrews JI, Griffith TS, Meier JL, (2007) Cytomegalovirus and the role of interferon in the expression of tumor necrosis factor-related apoptosis-inducing ligand in the placenta. Am J Obstet Gynecol 197: 608 e601-606.
33. Babu CK, Suwansrinon K, Bren GD, Badley AD, Rizza SA, (2009) HIV induces TRAIL sensitivity in hepatocytes. PLoS One 4: e4623.
34. van Noesel MM, van Bezouw S, Salomons GS, Voute PA, Pieters R, et al. (2002) Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation. Cancer Res 62: 2157-2161.
35. Sharp DA, Lawrence DA, Ashkenazi A, (2005) Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis. J Biol Chem 280: 19401-19409.
36. Thome M, Tschopp J, (2001) Regulation of lymphocyte proliferation and death by FLIP. Nat Rev Immunol 1: 50-58.
37. Deveraux QL, Reed JC, (1999) IAP family proteins-suppressors of apoptosis. Genes Dev 13: 239-252.
38. Adams JM, Cory S, (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326.
39. Aillet F, Masutani H, Elbim C, Raoul H, Chene L, et al. (1998) Human immunodeficiency virus induces a dual regulation of Bcl-2, resulting in persistent infection of CD4(+) T- or monocytic cell lines. J Virol 72: 9698-9705.
40. Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, et al. (2000) Activation of the NF-kappaB pathway by caspase 8 and its homologs. Oncogene 19: 4451-4460.
41. Kataoka T, Budd RC, Holler N, Thome M, Martinon F, et al. (2000) The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr Biol 10: 640-648.
42. Shu HB, Halpin DR, Goeddel DV, (1997) Casper is a FADD- and caspase-related inducer of apoptosis. Immunity 6: 751-763.
43. Shih CM, Ko WC, Wu JS, Wei YH, Wang LF, et al. (2004) Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts. J Cell Biochem 91: 384-397.
44. Saeki K, Kobayashi N, Inazawa Y, Zhang H, Nishitoh H, et al. (2002) Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis. Biochem J 368: 705-720.
45. Chen C, Liu Y, Zheng D, (2009) An agonistic monoclonal antibody against DR5 induces ROS production, sustained JNK activation and Endo G release in Jurkat leukemia cells. Cell Res 19: 984-995.