An agonistic monoclonal antibody against DR5 induces ROS production, sustained JNK activation and endo G release in jurkat leukemia cells

Cell Research

Volumn 19, Issue 8, 2009, Pages 984-995

  Chen, Caifeng ^a   Liu, Yanxin ^a   Zheng, Dexian ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

AD5 10; DR5; JNK; ROS; TRAIL

Indexed keywords

ACETYLCYSTEINE; CASPASE 8; DEOXYRIBONUCLEASE; ENDONUCLEASE G; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCLONAL ANTIBODY; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; DRUG POTENTIATION; ENZYMOLOGY; HUMAN; LEUKEMIA; LEUKEMIA CELL LINE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ACETYLCYSTEINE; ANTIBODIES, MONOCLONAL; APOPTOSIS; CASPASE 8; CELL LINE, TUMOR; ENDODEOXYRIBONUCLEASES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; LEUKEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-KAPPA B; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION;

EID: 68749110548     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2009.60     Document Type: Article

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