메뉴 건너뛰기




Volumn 52, Issue 4, 2011, Pages 269-279

The rat gut micronucleus assay: A good choice for alternative in vivo genetic toxicology testing strategies

Author keywords

Aneugenicity; Clastogenicity; GI tract; In vivo micronucleus test

Indexed keywords

ACETYLSALICYLIC ACID; CARBENDAZIM; CYCLOPHOSPHAMIDE; DIMETHYLHYDRAZINE; MITOMYCIN C; VINBLASTINE SULFATE;

EID: 79953723738     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20616     Document Type: Article
Times cited : (18)

References (58)
  • 2
    • 0023871944 scopus 로고
    • Species-specific response to the rodent carcinogens 1,2-DMH and 1,2-dibromo-3-chloropropane in rodent bone-marrow micronucleus assays
    • Albanese R, Mirkova E, Gatehouse D, Ashby J. 1988. Species-specific response to the rodent carcinogens 1, 2-DMH and 1, 2-dibromo-3-chloropropane in rodent bone-marrow micronucleus assays. Mutagen 3: 35-38.
    • (1988) Mutagen , vol.3 , pp. 35-38
    • Albanese, R.1    Mirkova, E.2    Gatehouse, D.3    Ashby, J.4
  • 3
    • 0029154091 scopus 로고
    • Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks
    • Anderson D, Bishop JB, Garner RC, Ostrosky-Wegman P, Selby PB. 1995. Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks. Mutat Res 330: 115-181.
    • (1995) Mutat Res , vol.330 , pp. 115-181
    • Anderson, D.1    Bishop, J.B.2    Garner, R.C.3    Ostrosky-Wegman, P.4    Selby, P.B.5
  • 4
    • 0034212378 scopus 로고    scopus 로고
    • Effect of dehydrated carrot on the antioxidant enzymes and micronuclei formation in rats challenged with dimethylhydrazine
    • Anilakumar KR, Khanum F, Sudarshanakrishna KR, Viswanathan KR, Santhanam K. 2000. Effect of dehydrated carrot on the antioxidant enzymes and micronuclei formation in rats challenged with dimethylhydrazine. Nutr Res 20: 893-897.
    • (2000) Nutr Res , vol.20 , pp. 893-897
    • Anilakumar, K.R.1    Khanum, F.2    Sudarshanakrishna, K.R.3    Viswanathan, K.R.4    Santhanam, K.5
  • 5
    • 0037180387 scopus 로고    scopus 로고
    • Enhancing the in vitro and in vivo detection of aneuploidy by fluorescence in situ hybridization with the use of bromodeoxyuridine as a proliferation marker
    • Balakrishnan S, Payawal J, Schuler MJ, Hasegawa L, Eastmond DA. 2002a. Enhancing the in vitro and in vivo detection of aneuploidy by fluorescence in situ hybridization with the use of bromodeoxyuridine as a proliferation marker. Mutat Res 521: 81-89.
    • (2002) Mutat Res , vol.521 , pp. 81-89
    • Balakrishnan, S.1    Payawal, J.2    Schuler, M.J.3    Hasegawa, L.4    Eastmond, D.A.5
  • 6
    • 0036155611 scopus 로고    scopus 로고
    • Detection of micronuclei, cell proliferation and hyperdiploidy in bladder epithelial cells of rats treated with o-phenylphenol
    • Balakrishnan S, Uppala PT, Rupa DS, Hasegawa L, Eastmond DA. 2002b. Detection of micronuclei, cell proliferation and hyperdiploidy in bladder epithelial cells of rats treated with o-phenylphenol. Mutagen 17: 89-93.
    • (2002) Mutagen , vol.17 , pp. 89-93
    • Balakrishnan, S.1    Uppala, P.T.2    Rupa, D.S.3    Hasegawa, L.4    Eastmond, D.A.5
  • 8
    • 0022897086 scopus 로고
    • The mechanism of removal of leukocytes by cellulose columns
    • Beutler E, Gelbart T. 1986. The mechanism of removal of leukocytes by cellulose columns. Blood Cells 12: 57-64.
    • (1986) Blood Cells , vol.12 , pp. 57-64
    • Beutler, E.1    Gelbart, T.2
  • 10
    • 33845286148 scopus 로고    scopus 로고
    • In vivo micronucleus test with flow cytometry after acute and chronic exposures of rats to chemicals
    • Cammerer Z, Elhajouji A, Suter W. 2007a. In vivo micronucleus test with flow cytometry after acute and chronic exposures of rats to chemicals. Mutat Res 626: 26-33.
    • (2007) Mutat Res , vol.626 , pp. 26-33
    • Cammerer, Z.1    Elhajouji, A.2    Suter, W.3
  • 11
    • 33847660479 scopus 로고    scopus 로고
    • Comparison of the peripheral blood micronucleus test using flow cytometry in rat and mouse exposed to aneugens after single-dose applications
    • Cammerer Z, Elhajouji A, Kirsch-Volders M, Suter W. 2007b. Comparison of the peripheral blood micronucleus test using flow cytometry in rat and mouse exposed to aneugens after single-dose applications. Mutagen 22: 129-134.
    • (2007) Mutagen , vol.22 , pp. 129-134
    • Cammerer, Z.1    Elhajouji, A.2    Kirsch-Volders, M.3    Suter, W.4
  • 12
    • 45949118247 scopus 로고
    • Genotoxicity of analgesic compounds assessed by an in vitro micronucleus assay
    • Dunn TL, Gardiner RA, Seymour GJ, Lavin MF. 1987. Genotoxicity of analgesic compounds assessed by an in vitro micronucleus assay. Mutat Res 189: 299-306.
    • (1987) Mutat Res , vol.189 , pp. 299-306
    • Dunn, T.L.1    Gardiner, R.A.2    Seymour, G.J.3    Lavin, M.F.4
  • 13
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech M. 2000. The in vitro micronucleus technique. Mutat Res 455: 81-95.
    • (2000) Mutat Res , vol.455 , pp. 81-95
    • Fenech, M.1
  • 15
    • 13844323014 scopus 로고
    • The genetic toxicology of paracetamol and aspirin: A review
    • Giri AK. 1993. The genetic toxicology of paracetamol and aspirin: A review. Mutat Res 296: 199-210.
    • (1993) Mutat Res , vol.296 , pp. 199-210
    • Giri, A.K.1
  • 16
    • 0030586767 scopus 로고    scopus 로고
    • Comparative genotoxicity of six salicylic acid derivatives in bone marrow cells of mice
    • Giri AK, Adhikari N, Khan KA. 1996. Comparative genotoxicity of six salicylic acid derivatives in bone marrow cells of mice. Mutat Res 370: 1-9.
    • (1996) Mutat Res , vol.370 , pp. 1-9
    • Giri, A.K.1    Adhikari, N.2    Khan, K.A.3
  • 17
    • 0020526347 scopus 로고
    • Comparison of the effects of 1,2-dimethylhydrazine and cyclophosphamide on micronucleus incidence in bone marrow and colon
    • Goldberg MT, Blakey DH, Bruce WR. 1983. Comparison of the effects of 1, 2-dimethylhydrazine and cyclophosphamide on micronucleus incidence in bone marrow and colon. Mutat Res 109: 91-98.
    • (1983) Mutat Res , vol.109 , pp. 91-98
    • Goldberg, M.T.1    Blakey, D.H.2    Bruce, W.R.3
  • 19
    • 0035934436 scopus 로고    scopus 로고
    • Evaluation of the general suitability of the rat for the micronucleus assay: The effect of cyclophosphamide in 14 strains
    • Hamada S, Yamasaki KI, Nakanishi S, Omori T, Serikawa T, Hayashi M. 2001b. Evaluation of the general suitability of the rat for the micronucleus assay: The effect of cyclophosphamide in 14 strains. Mutat Res 495: 127-134.
    • (2001) Mutat Res , vol.495 , pp. 127-134
    • Hamada, S.1    Yamasaki, K.I.2    Nakanishi, S.3    Omori, T.4    Serikawa, T.5    Hayashi, M.6
  • 20
    • 0038054727 scopus 로고    scopus 로고
    • The effect of aging on the results of the rat micronucleus assay
    • Hamada S, Nakajima K, Serikawa T, Hayashi M. 2003. The effect of aging on the results of the rat micronucleus assay. Mutagen 18: 273-275.
    • (2003) Mutagen , vol.18 , pp. 273-275
    • Hamada, S.1    Nakajima, K.2    Serikawa, T.3    Hayashi, M.4
  • 21
  • 22
    • 0020511885 scopus 로고
    • The induction of micronuclei as a measure of genotoxicity. A report of the U.S. Environmental Protection Agency Gene-Tox Program
    • Heddle JA, Hite M, Kirkhart B, Mavournin K, MacGregor JT, Newell GW, Salamone MF. 1983. The induction of micronuclei as a measure of genotoxicity. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res 123: 61-118.
    • (1983) Mutat Res , vol.123 , pp. 61-118
    • Heddle, J.A.1    Hite, M.2    Kirkhart, B.3    Mavournin, K.4    MacGregor, J.T.5    Newell, G.W.6    Salamone, M.F.7
  • 23
    • 0030913564 scopus 로고    scopus 로고
    • A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay
    • Holden HE, Majeska JB, Studwell D. 1997. A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay. Mutat Res 391: 87-89.
    • (1997) Mutat Res , vol.391 , pp. 87-89
    • Holden, H.E.1    Majeska, J.B.2    Studwell, D.3
  • 24
    • 0019124039 scopus 로고
    • Chromosome aberration tests with Chinese hamster cells in vitro with and without metabolic activation-A comparative study on mutagens and carcinogens
    • Ishidate MJr, Yoshikawa K. 1980. Chromosome aberration tests with Chinese hamster cells in vitro with and without metabolic activation-A comparative study on mutagens and carcinogens. Arch Toxicol Suppl 4: 41-44.
    • (1980) Arch Toxicol Suppl , vol.4 , pp. 41-44
    • Ishidate Jr, M.1    Yoshikawa, K.2
  • 25
    • 0023855146 scopus 로고
    • A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures
    • Ishidate MJr, Harnois MC, Sofuni T. 1988. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat Res 195: 151-213.
    • (1988) Mutat Res , vol.195 , pp. 151-213
    • Ishidate Jr, M.1    Harnois, M.C.2    Sofuni, T.3
  • 26
    • 0026728950 scopus 로고
    • Vinblastine treatment induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow
    • Jagetia GC, Jacob PS. 1992. Vinblastine treatment induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow. Mutat Res 280: 87-92.
    • (1992) Mutat Res , vol.280 , pp. 87-92
    • Jagetia, G.C.1    Jacob, P.S.2
  • 27
    • 0043031147 scopus 로고    scopus 로고
    • Assessment of non-steroidal anti-inflammatory drug (NSAID) damage in the human gastrointestinal tract
    • James MW, Hawkey CJ. 2003. Assessment of non-steroidal anti-inflammatory drug (NSAID) damage in the human gastrointestinal tract. Br J Clin Pharmacol 56: 146-155.
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 146-155
    • James, M.W.1    Hawkey, C.J.2
  • 28
    • 0023097315 scopus 로고
    • Absence of mutagenic activity of benorylate, paracetamol and aspirin in the Salmonella/mammalian microsome test
    • Jasiewicz ML, Richardson JC. 1987. Absence of mutagenic activity of benorylate, paracetamol and aspirin in the Salmonella/mammalian microsome test. Mutat Res 190: 95-100.
    • (1987) Mutat Res , vol.190 , pp. 95-100
    • Jasiewicz, M.L.1    Richardson, J.C.2
  • 29
    • 0021688019 scopus 로고
    • Mutagenicity examination of several non-steroidal anti-inflammatory drugs in bacterial systems
    • Kadotani S, Arisawa M, Maruyama HB. 1984. Mutagenicity examination of several non-steroidal anti-inflammatory drugs in bacterial systems. Mutat Res 138: 133-136.
    • (1984) Mutat Res , vol.138 , pp. 133-136
    • Kadotani, S.1    Arisawa, M.2    Maruyama, H.B.3
  • 31
    • 0018305194 scopus 로고
    • Mutagenicity studies with x-ray-contrast media, analgesics, antipyretics, antirheumatics and some other pharmaceutical drugs in bacterial, Drosophila and mammalian test systems
    • King MT, Beikirch H, Eckhardt K, Gocke E, Wild D. 1979. Mutagenicity studies with x-ray-contrast media, analgesics, antipyretics, antirheumatics and some other pharmaceutical drugs in bacterial, Drosophila and mammalian test systems. Mutat Res 66: 33-43.
    • (1979) Mutat Res , vol.66 , pp. 33-43
    • King, M.T.1    Beikirch, H.2    Eckhardt, K.3    Gocke, E.4    Wild, D.5
  • 32
    • 0026708420 scopus 로고
    • Simultaneous evaluation of clastogenicity, aneugenicity and toxicity in the mouse micronucleus assay using immunofluorescence
    • Krishna G, Fiedler R, Theiss JC. 1992. Simultaneous evaluation of clastogenicity, aneugenicity and toxicity in the mouse micronucleus assay using immunofluorescence. Mutat Res 282: 159-167.
    • (1992) Mutat Res , vol.282 , pp. 159-167
    • Krishna, G.1    Fiedler, R.2    Theiss, J.C.3
  • 33
    • 33749584330 scopus 로고    scopus 로고
    • Flow cytometric analysis of micronuclei in peripheral blood reticulocytes. II. An efficient method of monitoring chromosomal damage in the rat
    • Dertinger SD.
    • MacGregor JT, Bishop ME, McNamee JP, Hayashi M, Asano N, Wakata A, Nakajima M, Saito J, Aidoo A, Moore MM, Dertinger SD. 2006. Flow cytometric analysis of micronuclei in peripheral blood reticulocytes. II. An efficient method of monitoring chromosomal damage in the rat. Toxicol Sci 94: 92-107.
    • (2006) Toxicol Sci , vol.94 , pp. 92-107
    • MacGregor, J.T.1    Bishop, M.E.2    McNamee, J.P.3    Hayashi, M.4    Asano, N.5    Wakata, A.6    Nakajima, M.7    Saito, J.8    Aidoo, A.9    Moore, M.M.10
  • 35
    • 0036709215 scopus 로고    scopus 로고
    • A survey of EPA/OPP and open literature on selected pesticide chemicals. III. Mutagenicity and carcinogenicity of benomyl and carbendazim
    • McCarroll NE, Protzel A, Ioannou Y, Frank Stack HF, Jackson MA, Waters MD, Dearfield KL. 2002. A survey of EPA/OPP and open literature on selected pesticide chemicals. III. Mutagenicity and carcinogenicity of benomyl and carbendazim. Mutat Res 512: 1-35.
    • (2002) Mutat Res , vol.512 , pp. 1-35
    • McCarroll, N.E.1    Protzel, A.2    Ioannou, Y.3    Frank Stack, H.F.4    Jackson, M.A.5    Waters, M.D.6    Dearfield, K.L.7
  • 36
    • 0028986406 scopus 로고
    • High resolution rodent bone marrow micronucleus assays of 1,2-dimethylhydrazine: Implication of systemic toxicity an individual responders
    • Morrison V, Ashby J. 1995. High resolution rodent bone marrow micronucleus assays of 1, 2-dimethylhydrazine: Implication of systemic toxicity an individual responders. Mutagen 10: 129-135.
    • (1995) Mutagen , vol.10 , pp. 129-135
    • Morrison, V.1    Ashby, J.2
  • 37
    • 0033795967 scopus 로고    scopus 로고
    • Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system
    • Nakayama A, Saitoh H, Oda M, Takada M, Aungst BJ. 2000. Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system. Eur J Pharm Sci 11: 317-324.
    • (2000) Eur J Pharm Sci , vol.11 , pp. 317-324
    • Nakayama, A.1    Saitoh, H.2    Oda, M.3    Takada, M.4    Aungst, B.J.5
  • 39
    • 0022516588 scopus 로고
    • Mutagenicity testing of selected analgesics in Ames Salmonella strains
    • Oldham JW, Preston RF, Paulson JD. 1986. Mutagenicity testing of selected analgesics in Ames Salmonella strains. J Appl Toxicol 6: 237-243.
    • (1986) J Appl Toxicol , vol.6 , pp. 237-243
    • Oldham, J.W.1    Preston, R.F.2    Paulson, J.D.3
  • 40
    • 58249121987 scopus 로고    scopus 로고
    • Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice
    • Poul M, Jarry G, Elhkim MO, Poul JM. 2009. Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice. Food Chem Toxicol 47: 443-448.
    • (2009) Food Chem Toxicol , vol.47 , pp. 443-448
    • Poul, M.1    Jarry, G.2    Elhkim, M.O.3    Poul, J.M.4
  • 41
    • 0023161374 scopus 로고
    • 32P-analysis of DNA adducts in somatic and reproductive tissues of rats treated with the anticancer antibiotic, mitomycin C
    • Reddy MV, Randerath K. 1987. 32P-analysis of DNA adducts in somatic and reproductive tissues of rats treated with the anticancer antibiotic, mitomycin C. Mutat Res 179: 75-88.
    • (1987) Mutat Res , vol.179 , pp. 75-88
    • Reddy, M.V.1    Randerath, K.2
  • 42
    • 0027530664 scopus 로고
    • The gastrointestinal toxicity of aspirin: An overview of randomised controlled trials
    • Roderick PJ, Wilkes HC, Meade TW. 1993. The gastrointestinal toxicity of aspirin: An overview of randomised controlled trials. Br J Clin Pharmacol 35: 219-226.
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 219-226
    • Roderick, P.J.1    Wilkes, H.C.2    Meade, T.W.3
  • 43
    • 0029953050 scopus 로고    scopus 로고
    • Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery
    • Rouge N, Buri P, Doelker E. 1996. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int J Pharm 136: 117-139.
    • (1996) Int J Pharm , vol.136 , pp. 117-139
    • Rouge, N.1    Buri, P.2    Doelker, E.3
  • 44
    • 23644444334 scopus 로고    scopus 로고
    • Chromosome breakage is primarily responsible for the micronuclei induced by 1,4-dioxane in the bone marrow and liver of young CD-1 mice
    • Roy SK, Thilagar AK, Eastmond DA. 2005. Chromosome breakage is primarily responsible for the micronuclei induced by 1, 4-dioxane in the bone marrow and liver of young CD-1 mice. Mutat Res 586: 28-37.
    • (2005) Mutat Res , vol.586 , pp. 28-37
    • Roy, S.K.1    Thilagar, A.K.2    Eastmond, D.A.3
  • 46
    • 0024390863 scopus 로고
    • A comparison of intraperitoneal injection and oral gavage in the micronucleus test with mitomycin C in mice
    • Sato S, Inui N, Ikeda Y, Hiraga Y. 1989. A comparison of intraperitoneal injection and oral gavage in the micronucleus test with mitomycin C in mice. Mutat Res 223: 387-390.
    • (1989) Mutat Res , vol.223 , pp. 387-390
    • Sato, S.1    Inui, N.2    Ikeda, Y.3    Hiraga, Y.4
  • 47
    • 0035958282 scopus 로고    scopus 로고
    • A comparison of intraperitoneal and oral gavage administration in comet assay in mouse eight organs
    • Sekihashi K, Sasaki T, Yamamoto A, Kawamura K, Ikka T, Tsuda S, Sasaki YF. 2001. A comparison of intraperitoneal and oral gavage administration in comet assay in mouse eight organs. Mutat Res 493: 39-54.
    • (2001) Mutat Res , vol.493 , pp. 39-54
    • Sekihashi, K.1    Sasaki, T.2    Yamamoto, A.3    Kawamura, K.4    Ikka, T.5    Tsuda, S.6    Sasaki, Y.F.7
  • 48
    • 0033514454 scopus 로고    scopus 로고
    • Rapid method for improving slide quality in the bone marrow micronucleus assay; an adapted cellulose column procedure
    • Sun JT, Armstrong MJ, Galloway SM. 1999. Rapid method for improving slide quality in the bone marrow micronucleus assay; an adapted cellulose column procedure. Mutat Res 439: 121-126.
    • (1999) Mutat Res , vol.439 , pp. 121-126
    • Sun, J.T.1    Armstrong, M.J.2    Galloway, S.M.3
  • 49
    • 0020387622 scopus 로고
    • Effect of cell proliferation and loss on aspirin-induced gastric damage in the rat
    • Takeuchi K, Johnson LR. 1982. Effect of cell proliferation and loss on aspirin-induced gastric damage in the rat. Am J Physiol 243: G463-G468.
    • (1982) Am J Physiol , vol.243
    • Takeuchi, K.1    Johnson, L.R.2
  • 50
    • 0034673206 scopus 로고    scopus 로고
    • Enumeration of micronucleated reticulocytes in rat peripheral blood: A flow cytometric study
    • Torous DK, Dertinger SD, Hall NE, Tometsko CR. 2000. Enumeration of micronucleated reticulocytes in rat peripheral blood: A flow cytometric study. Mutat Res 465: 91-99.
    • (2000) Mutat Res , vol.465 , pp. 91-99
    • Torous, D.K.1    Dertinger, S.D.2    Hall, N.E.3    Tometsko, C.R.4
  • 51
    • 0042591389 scopus 로고    scopus 로고
    • Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy
    • Torous DK, Hall NE, Murante FG, Gleason SE, Tometsko CR, Dertinger SD. 2003. Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy. Toxicol Sci 74: 309-314.
    • (2003) Toxicol Sci , vol.74 , pp. 309-314
    • Torous, D.K.1    Hall, N.E.2    Murante, F.G.3    Gleason, S.E.4    Tometsko, C.R.5    Dertinger, S.D.6
  • 52
    • 0017823520 scopus 로고
    • The evaluation of sixteen carcinogens in the rat using the micronucleus test
    • Trzos RJ, Petzold GL, Brunden MN, Swenberg JA. 1978. The evaluation of sixteen carcinogens in the rat using the micronucleus test. Mutat Res 58: 79-86.
    • (1978) Mutat Res , vol.58 , pp. 79-86
    • Trzos, R.J.1    Petzold, G.L.2    Brunden, M.N.3    Swenberg, J.A.4
  • 53
    • 0041981639 scopus 로고    scopus 로고
    • A method to score micronuclei in vivo using cytochalasin B-induced cytokinesis block
    • Uma Devi P, Satish Rao BS, Kamath R. 1998. A method to score micronuclei in vivo using cytochalasin B-induced cytokinesis block. Mutat Res 401: 33-37.
    • (1998) Mutat Res , vol.401 , pp. 33-37
    • Uma Devi, P.1    Satish Rao, B.S.2    Kamath, R.3
  • 54
    • 0035168394 scopus 로고    scopus 로고
    • The in vivo gut micronucleus test detects clastogens and aneugens given by gavage
    • Vanhauwaert A, Vanparys P, Kirsch-Volders M. 2001. The in vivo gut micronucleus test detects clastogens and aneugens given by gavage. Mutagen 16: 39-50.
    • (2001) Mutagen , vol.16 , pp. 39-50
    • Vanhauwaert, A.1    Vanparys, P.2    Kirsch-Volders, M.3
  • 55
    • 0025346326 scopus 로고
    • The micronucleus assay as a test for the detection of aneugenic activity
    • Vanparys P, Vermeiren F, Sysmans M, Temmerman R. 1990. The micronucleus assay as a test for the detection of aneugenic activity. Mutat Res 244: 95-103.
    • (1990) Mutat Res , vol.244 , pp. 95-103
    • Vanparys, P.1    Vermeiren, F.2    Sysmans, M.3    Temmerman, R.4
  • 56
    • 0031904574 scopus 로고    scopus 로고
    • Evaluation of the rat micronucleus test with bone marrow and peripheral blood: Summary of the 9th collaborative study by CSGMT/JEMS. MMS. Collaborative Study Group for the micronucleus test. Environ Mutagen Society of Japan Mammalian Mutagenicity Study Group
    • Wakata A, Miyamae Y, Sato S, Suzuki T, Morita T, Asano N, Awogi T, Kondo K, Hayashi M. 1998. Evaluation of the rat micronucleus test with bone marrow and peripheral blood: Summary of the 9th collaborative study by CSGMT/JEMS. MMS. Collaborative Study Group for the micronucleus test. Environ Mutagen Society of Japan Mammalian Mutagenicity Study Group. Environ Mol Mutagen 32: 84-100.
    • (1998) Environ Mol Mutagen , vol.32 , pp. 84-100
    • Wakata, A.1    Miyamae, Y.2    Sato, S.3    Suzuki, T.4    Morita, T.5    Asano, N.6    Awogi, T.7    Kondo, K.8    Hayashi, M.9
  • 57
    • 0015097207 scopus 로고
    • Colon carcinogens: Their metabolism and mode of action
    • Weisburger JH. 1971. Colon carcinogens: Their metabolism and mode of action. Cancer 28: 60-70.
    • (1971) Cancer , vol.28 , pp. 60-70
    • Weisburger, J.H.1
  • 58
    • 0030580937 scopus 로고    scopus 로고
    • Selective induction of micronuclei in the rat/mouse colon and liver by 1,2-dimethylhydrazine: A seven-tissue comparative study
    • Zhurkov VS, Sycheva LP, Salamatova O, Vyskubenko If, Feldt EG, Sherenesheva NI. 1996. Selective induction of micronuclei in the rat/mouse colon and liver by 1, 2-dimethylhydrazine: A seven-tissue comparative study. Mutat Res 368: 115-120.
    • (1996) Mutat Res , vol.368 , pp. 115-120
    • Zhurkov, V.S.1    Sycheva, L.P.2    Salamatova, O.3    Vyskubenko, I.4    Feldt, E.G.5    Sherenesheva, N.I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.