Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat

Toxicological Sciences

Volumn 94, Issue 1, 2006, Pages 92-107

  MacGregor, James T ^a,i   Bishop, Michelle E ^b   McNamee, James P ^c   Hayashi, Makoto ^d   Asano, Norhide ^e   Wakata, Akihiro ^f   Nakajima, Madoka ^g   Saito, Junichiro ^f   Aidoo, Anane ^b   Moore, Martha M ^b   Dertinger, Stephen D ^h  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c HEALTH CANADA   (Canada)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^e NITTO DENKO CORPORATION   (Japan)

^f ASTELLAS PHARMA INC   (Japan)

^g An Pyo Center   (Japan)

^h LITRON LABORATORIES   (United States)

ⁱ Toxicology Consulting Services   (United States)

Author keywords

Cyclophosphamide, cis platin; Erythrocytes; Flow cytometric analysis; Micronucleated reticulocytes; Vinblastine

Indexed keywords

ACRIDINE ORANGE; CD71 ANTIGEN; CELL DNA; CISPLATIN; CYCLOPHOSPHAMIDE; FLUORESCEIN ISOTHIOCYANATE; METHANOL; PROPIDIUM IODIDE; RIBONUCLEASE; TOXIC SUBSTANCE; TRANSFERRIN RECEPTOR; VINBLASTINE;

ACCURACY; ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; BLOOD EXAMINATION; BONE MARROW; CELL LABELING; CHROMOSOME DAMAGE; CONTROLLED STUDY; DNA CONTENT; ERYTHROCYTE; FEMALE; FLOW CYTOMETRY; GENOTOXICITY; INTERMETHOD COMPARISON; MALE; METHODOLOGY; MICRONUCLEUS; MICROSCOPY; NONHUMAN; PLASMODIUM; RAT; RAT STRAIN; REPRODUCIBILITY; RETICULOCYTE; SCORING SYSTEM; SPLEEN; SPLENECTOMY;

ACRIDINE ORANGE; ANIMALS; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; CHROMOSOME ABERRATIONS; CISPLATIN; CYCLOPHOSPHAMIDE; FEMALE; FLOW CYTOMETRY; LABORATORY TECHNIQUES AND PROCEDURES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MICROSCOPY, FLUORESCENCE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RETICULOCYTES; SPLENECTOMY; STAINING AND LABELING; TIME FACTORS; VINBLASTINE;

EID: 33749584330     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl076     Document Type: Article

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