Hedgehog inhibition promotes a switch from type II to type I cell death receptor signaling in cancer cells

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Kurita, Satoshi ^a   Mott, Justin L ^a   Cazanave, Sophie C ^a   Fingas, Christian D ^a   Guicciardi, Maria E ^a   Bronk, Steve F ^a   Roberts, Lewis R ^a   Fernandez Zapico, Martin E ^a   Gores, Gregory J ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; DEATH RECEPTOR 4; DEATH RECEPTOR 5; INHIBITOR OF APOPTOSIS PROTEIN 1; PROTEIN BAK; PROTEIN BAX; PROTEIN BID; SMALL INTERFERING RNA; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; X LINKED INHIBITOR OF APOPTOSIS; APOPTOSIS REGULATORY PROTEIN; BCL 2 LIKE PROTEIN 11; BCL-2-LIKE PROTEIN 11; BID PROTEIN, HUMAN; CYCLOPAMINE; GLI1 PROTEIN, HUMAN; GLI2 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; KRUPPEL LIKE FACTOR; MEMBRANE PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; TRANSCRIPTION FACTOR; VERATRUM ALKALOID; XIAP PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; GENETICS; IMMUNOBLOTTING; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL LINE;

ERINACEIDAE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CELL LINE; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEDGEHOG PROTEINS; HUMANS; IMMUNOBLOTTING; INHIBITOR OF APOPTOSIS PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MEMBRANE PROTEINS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTORS; VERATRUM ALKALOIDS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 79953666636     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018330     Document Type: Article

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