Serine 363 of the δ-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands

Journal of Cell Science

Volumn 123, Issue 24, 2010, Pages 4259-4270

  Xu, Chi ^a   Hong, Min Hua ^a   Zhang, Le Sha ^a   Hou, Yuan Yuan ^a   Wang, Yu Hua ^a   Wang, Fei Fei ^b   Chen, Yue Jun ^b   Xu, Xue Jun ^a   Chen, Jie ^a   Xie, Xin ^a   Ma, Lan ^b   Chi, Zhi Qiang ^a   Liu, Jing Gen ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

arrestins; opioid receptor; ERK; GPCR; GRK; Serine 363 phosphorylation

Indexed keywords

BETA ARRESTIN; BETA ARRESTIN 1; BETA ARRESTIN 2; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SERINE;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DESENSITIZATION; FEMALE; GENE EXPRESSION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ARRESTINS; CYTOPLASM; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENZYME ACTIVATION; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; LIGANDS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUTANT PROTEINS; MUTATION; OLIGOPEPTIDES; PHOSPHOLIPASE C BETA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RECEPTORS, OPIOID, DELTA; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; TETRAHYDROISOQUINOLINES;

EID: 78649744383     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.073742     Document Type: Article

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