Ataxia telangiectasia and rad3-related overexpressing cancer cells induce prolonged G2 arrest and develop resistance to ionizing radiation

DNA and Cell Biology

Volumn 30, Issue 4, 2011, Pages 219-227

  Kim, Young Mee ^a,b   Lee, Yeo Myoung ^a,b   Park, Soo Yeon ^a,b   Pyo, Hongryull ^a,b  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b National Cancer Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN;

ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL STRESS; DNA DAMAGE; DNA REPAIR; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IONIZING RADIATION; PHOSPHORYLATION; PRIORITY JOURNAL; RADIOSENSITIVITY;

ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CELL CYCLE PROTEINS; DNA DAMAGE; DNA REPAIR; G2 PHASE; HCT116 CELLS; HISTONES; HUMANS; NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RADIATION, IONIZING; TUMOR SUPPRESSOR PROTEIN P53;

ATAXIA TELANGIECTASIA;

EID: 79953246979     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2010.1141     Document Type: Article

References (35)

1. Al Rashid, S.T., Dellaire, G., Cuddihy, A., Jalali, F., Vaid, M., Coackley, C., Folkard, M., Xu, Y., Chen, B.P., Chen, D.J., Lilge, L., Prise, K.M., Bazett Jones, D.P., and Bristow, R.G. (2005). Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Res 65, 10810-10821. (Pubitemid 41713348)
2. Auclair, Y., Rouget, R., Affar el, B., and Drobetsky, E.A. (2008). ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells. Proc Natl Acad Sci U S A 105, 17896-17901.
3. Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J.P., Sedivy, J.M., Kinzler, K.W., and Vogelstein, B. (1998). Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282, 1497-1501. (Pubitemid 28538613)
4. Charrier-Savournin, F.B., Chateau, M.T., Gire, V., Sedivy, J., Piette, J., and Dulic, V. (2004). p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. Mol Biol Cell 15, 3965-3976. (Pubitemid 39122002)
5. Cimprich, K.A. and Cortez, D. (2008). ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol 9, 616-627. (Pubitemid 352032926)
6. Cuadrado, M., Martinez-Pastor, B., and Fernandez-Capetillo, O. (2006a). ATR activation in response to ionizing radiation: still ATM territory. Cell Div 1, 7.
7. Cuadrado, M., Martinez-Pastor, B., Murga, M., Toledo, L.I., Gutierrez-Martinez, P., Lopez, E., and Fernandez-Capetillo, O. (2006b). ATM regulates ATR chromatin loading in response to DNA double-strand breaks. J Exp Med 203, 297-303. (Pubitemid 43290838)
8. Dierov, J., Dierova, R., and Carroll, M. (2004). BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint. Cancer Cell 5, 275-285. (Pubitemid 38402119)
9. Espinosa, J.M., Verdun, R.E., and Emerson, B.M. (2003). p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell 12, 1015-1027. (Pubitemid 37352792)
10. Fei, P., and El-Deiry, W.S. (2003). P53 and radiation responses. Oncogene 22, 5774-5783. (Pubitemid 37176699)
11. Fernandez-Capetillo, O., Chen, H.T., Celeste, A., Ward, I., Romanienko, P.J., Morales, J.C., Naka, K., Xia, Z., Camerini- Otero, R.D., Motoyama, N., Carpenter, P.B., Bonner, W.M., Chen, J., and Nussenzweig, A. (2002). DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol 4, 993-997. (Pubitemid 35469431)
12. Fragkos, M., Jurvansuu, J., and Beard, P. (2009). H2AX is required for cell cycle arrest via the p53/p21 pathway. Mol Cell Biol 29, 2828-2840.
13. Hurley, P.J., and Bunz, F. (2007). ATM and ATR: components of an integrated circuit. Cell Cycle 6, 414-417. (Pubitemid 46393443)
14. Hurley, P.J., Wilsker, D., and Bunz, F. (2007). Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation. Oncogene 26, 2535-2542. (Pubitemid 46632006)
15. Jun, H.J., Kim, Y.M., Park, S.Y., Park, J.S., Lee, E.J., Choi, S.A., and Pyo, H. (2009). Modulation of ionizing radiation-induced G2 arrest by cyclooxygenase-2 and its inhibitor celecoxib. Int J Radiat Oncol Biol Phys 75, 225-234.
16. Kim, M.J., Lee, J.Y., and Lee, S.J. (2008). Transient suppression of nuclear Cdc2 activity in response to ionizing radiation. Oncol Rep 19, 1323-1329.
17. Kim, Y.M., Lee, E.J., Park, S.Y., Cho, K.H., Kim, J.Y., and Pyo, H. (2009). Cyclooxygenase-2 up-regulates ataxia telangiectasia and Rad3 related through extracellular signal-regulated kinase activation. Mol Cancer Res 7, 1158-1168.
18. Liang, Y., Lin, S.Y., Brunicardi, F.C., Goss, J., and Li, K. (2009). DNA damage response pathways in tumor suppression and cancer treatment. World J Surg 33, 661-666.
19. Liu, A., Takakuwa, T., Fujita, S., Luo, W.J., Tresnasari, K., Van den Berg, A., Poppema, S., and Aozasa, K. (2008). ATR alterations in Hodgkin's lymphoma. Oncol Rep 19, 999-1005.
20. Liu, L., Choi, J.H., Yim, H., Choi, J.S., Park, B.D., Cho, S.J., and Lee, S.K. (2009). ATR (AT mutated Rad3 related) activity stabilizes Cdc6 and delays G2/M-phase entry during hydroxyurea-induced S-phase arrest of HeLa cells. Int J Biochem Cell Biol 41, 1410-1420.
21. Lobrich, M., and Jeggo, P.A. (2007). The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer 7, 861-869. (Pubitemid 350006255)
22. Myers, J.S., and Cortez, D. (2006). Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 281, 9346-9350. (Pubitemid 43864651)
23. Nghiem, P., Park, P.K., Kim, Y., Vaziri, C., and Schreiber, S.L. (2001). ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci U S A 98, 9092-9097. (Pubitemid 32743874)
24. O'Hagan, H.M., and Ljungman, M. (2004). Phosphorylation and nuclear accumulation are distinct events contributing to the activation of p53. Mutat Res 546, 7-15. (Pubitemid 38130214)
25. Park, J.H., Park, E.J., Hur, S.K., Kim, S., and Kwon, J. (2009). Mammalian SWI/SNF chromatin remodeling complexes are required to prevent apoptosis after DNA damage. DNA Repair (Amst) 8, 29-39.
26. Rodriguez-Bravo, V., Guaita-Esteruelas, S., Florensa, R., Bachs, O., and Agell, N. (2006). Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells. Cancer Res 66, 8672-8679. (Pubitemid 44449183)
27. Shin, Y.K., Park, J.S., Kim, H.S., Jun, H.J., Kim, G.E., Suh, C.O., Yun, Y.S., and Pyo, H. (2005). Radiosensitivity enhancement by celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, via COX-2-dependent cell cycle regulation on human cancer cells expressing differential COX-2 levels. Cancer Res 65, 9501-9509. (Pubitemid 41508020)
28. Stiff, T., Cerosaletti, K., Concannon, P., O'Driscoll, M., and Jeggo, P.A. (2008). Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1. Hum Mol Genet 17, 3247-3253.
29. Stiff, T., Walker, S.A., Cerosaletti, K., Goodarzi, A.A., Petermann, E., Concannon, P., O'Driscoll, M., and Jeggo, P.A. (2006). ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 25, 5775-5782. (Pubitemid 44967761)
30. Taylor, W.R., and Stark, G.R. (2001). Regulation of the G2/M transition by p53. Oncogene 20, 1803-1815. (Pubitemid 32458690)
31. Tomimatsu, N., Mukherjee, B., and Burma, S. (2009). Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep 10, 629-635.
32. Wang, X., Khadpe, J., Hu, B., Iliakis, G., and Wang, Y. (2003). An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells. J Biol Chem 278, 30869-30874. (Pubitemid 36994597)
33. Xu, B., Kim, S.T., Lim, D.S., and Kastan, M.B. (2002). Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 22, 1049-1059. (Pubitemid 34094842)
34. Yan, Y., Black, C.P., and Cowan, K.H. (2007). Irradiation-induced G2/M checkpoint response requires ERK1/2 activation. Oncogene 26, 4689-4698. (Pubitemid 47067411)
35. Zhang, X.H., Zhao, C., and Ma, Z.A. (2007). The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR. J Cell Sci 120, 4134-4143.