ATR alterations in Hodgkin's lymphoma

Oncology Reports

Volumn 19, Issue 4, 2008, Pages 999-1005

  Liu, Angen ^a   Takakuwa, Tetsuya ^a   Fujita, Shigeki ^a   Luo, Wen Juan ^a   Tresnasari, Kristianti ^a   Van Den Berg, Anke ^b   Poppema, Sibrand ^b   Aozasa, Katsuyuki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Ataxia telangiectasia mutated and Rad3 related gene; DNA repair; Double strand breaks; Hodgkin and Reed Sternberg cell; Hodgkin's lymphoma; Single strand break

Indexed keywords

ATR PROTEIN; DOUBLE STRANDED DNA; PROTEIN P53; ATR PROTEIN, HUMAN; CELL CYCLE PROTEIN; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE;

ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; EXON; FEMALE; FRAMESHIFT MUTATION; GENE DELETION; GENE INSERTION; GENE MUTATION; GENETIC POLYMORPHISM; HETEROZYGOSITY; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; LYMPHOMA CELL LINE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REED STERNBERG CELL; GENETICS; MIDDLE AGED; TUMOR CELL LINE;

ADULT; AGED; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA BREAKS; DNA REPAIR; FEMALE; HODGKIN DISEASE; HUMANS; MALE; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 43849098414     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.19.4.999     Document Type: Article

References (27)

1. Warnke RA, Weiss LM, Chan JKC, Cleary ML and Dorfman RF: Tumors of the lymph nodes and spleen. In: Atlas of tumor pathology. Rosai J and Sobin LH (ed.) Armed Forces Institute of Pathology, Washington DC, pp43, 1995.
2. Falzetti D, Crescenzi B, Matteuci C, Falini B, Martelli MF, Van Den Berghe H and Mecucci C: Genomic instability and recurrent breakpoints are main cytogenetic findings in Hodgkin's disease. Haematologica 84: 298-305, 1999.
3. Maggio E, Van den Berg A, Diepstra A, Kluiver J, Visser L and Poppema S: Chemokines, cytokines and their receptors in Hodgkin's lymphoma cell lines and tissues. Ann Oncol 1: 52-56, 2002.
4. Shiloh Y: ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3: 155-168, 2003.
5. Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ and Abraham RT: Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev 14: 2989-3002, 2000.
6. Zhou BB and Elledge SJ: The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439, 2000.
7. Khanna KK and Jackson SP: DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27: 247-254, 2001.
8. Rouse J and Jackson SP: Interfaces between the detection, signaling and repair of DNA damage. Science 297: 547-551, 2002.
9. Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL and Friend SH: Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J 17: 159-169, 1998.
10. O'Driscoll M, Ruiz PV, Woods CG, Jeggo PA and Goodship JA: A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet 33: 497-501, 2003.
11. Casper AM, Nghiem P, Arlt MF and Glover TW: ATR regulates fragile site stability. Cell 111: 779-789, 2002.
12. Liu A, Takakuwa T, Fujita S, Ham MF, Luo WJ, Daibata M and Aozasa K: Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma. Lab Invest 85: 436-446, 2005.
13. Abbott DW, Freeman ML and Holt JT: Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J Natl Cancer Inst 90: 978-985, 1998.
14. Tice RR, Agurell E, Anderson D, et al: Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35: 206-221, 2000.
15. Yamauchi T, Kawai Y and Ueda T: enhanced DNA excision repair in CCRF-CEM cells resistant to 1,3-bis (2-chloroethyl)-1-nitrosourea, quantitated using the single cell gel electrophoresis (Comet) assay. Biochem Pharmacol 66: 939-946, 2003.
16. Cimprich KA, Shin TB, Keith CT and Schreiber SL: cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci USA 93: 2850-2855, 1996.
17. Mannino JL, Kim W, Wernick M, et al: Evidence for alternate splicing within the mRNA transcript encoding the DNA damage response kinase Am. Gene 272: 35-43, 2001.
18. Liberzon E, Avigad S, Yaniv I, Stark B, Avrahami G, Goshen Y and Zaizov R: Molecular variants of the ATM gene in Hodgkin's disease in children. Br J Cancer 90: 522-525, 2004.
19. Takagi M, Tsuchida R, Oguchi K, et al: Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin's disease. Blood 103: 283-290, 2004.
20. Abraham RT: Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15: 2177-2196, 2001.
21. Menoyo A, Alazzouzi H, Espin E, Armengol M, Yamamoto H and Schwartz S Jr.: Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability. Cancer Res 61: 7727-7730, 2001.
22. Vassileva V, Millar A, Briollais L, Chapman W and Bapat B: Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability. Cancer Res 62: 4095-4099, 2002.
23. Mongiat-Artus P, Miquel C, Van der Aa M, et al: Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract. Oncogene 25: 2113-2118, 2006.
24. Li LS, Kim NG, Kim SH, et al: Chromosomal imbalances in the colorectal carcinomas with microsatellite instability. Am J Pathol 163: 1429-1436, 2003.
25. Brown EJ and Baltimore D: ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 14: 397-402, 2000.
26. de Klein A, Muijtjens M, van Os R, et al: Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol 10: 479-482, 2000.
27. Lewis KA, Mullany S, Thomas B, Chien J, Loewen R, Shridhar V and Cliby WA: Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance. Cancer Res 65: 7091-7095, 2005.