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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3606-3609

Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors

(2) Mohamed, Tarek a Rao, Praveen P N a

a UNIVERSITY OF WATERLOO (Canada)

Author keywords

2,4 Disubstituted pyrimidines; Acetylcholinesterase AChE; Butyrylcholinesterase BuChE; Molecular modeling

Indexed keywords

ACETYLCHOLINESTERASE; ALANINE; AMINO ACID; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; PHENYLALANINE; PYRIMIDINE DERIVATIVE; THIOMORPHOLINE DERIVATIVE; TRYPTOPHAN;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ELECTRONICS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954216576 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.04.108 Document Type: Article

Times cited : (34)

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